Did You Know...
...that a workman who left the soap mixing machine on too long was responsible for making Ivory Soap? He was so embarrassed by his mistake that he threw the mess in a stream. Imagine his dismay when the evidence of his error floated to the surface! Result: Ivory soap, the soap that floats.
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| Number | Title | Issue Date |
| 8150634 | Protein-ligand NOE matching for high-throughput structure determination A method of enhancing the throughput and applicability of NMR-based structure determination of protein-ligand complexes is disclosed. The method circumvents the need for protein sequence-specific resonance assignments and combines NMR data analysis and ligand dockin... | 04/03/2012 |
| 8129114 | Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators EGFR biomarkers useful in a method for predicting the likelihood that a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) measuring in the mammal the level of at least... | 03/06/2012 |
| 8124730 | Polynucleotide encoding a novel human P2X7 splice variant, HBMYP2X7v The present invention provides novel polynucleotides encoding HBMYP2X7v polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further re... | 02/28/2012 |
| 8124729 | Splice variants of human G-protein coupled receptor HGPRBMY29 (HGPRMBY29SV2) The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2.... | 02/28/2012 |
| 8119129 | Combination of anti-CTLA4 antibody with dasatinib for the treatment of proliferative diseases Compositions and methods are disclosed which are useful of the treatment and prevention of proliferative disorders. ... | 02/21/2012 |
| 8080636 | BSL3 antibodies The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related p... | 12/20/2011 |
| 7846706 | PCSK9 polypeptides The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention fu... | 12/07/2010 |
| 7846671 | Methods of screening for agents that modulate the interaction of RGS and Gαq and urinary incontinence The present invention provides methods that are useful for the treatment or prevention of smooth muscle disorders such as urinary incontinence and compounds that are useful in such methods. ... | 12/07/2010 |
| 7851190 | Biosynthetic gene cluster for leptomycins Polypeptides and domains of leptomycin polyketide synthase and the nucleic acids encoding them are provided. Methods to prepare leptomycin, leptomycin analogs, and leptomycin derivatives are described, as are methods to prepare other polyketides using the nucleic ac... | 12/14/2010 |
| 7811787 | Polynucleotides encoding human SLAP-2 variant, hSLAP-2v3 The invention relates to the identification and cloning of a two novel full-length human SLAP-2 variants and their encoded polypeptides, hSLAP-2v3 and hSLAP-2v4. hSLAP-2v3 and hSLAP-2v4 are members of the SLAP family of adapter proteins and are involved in the negat... | 10/12/2010 |
| 7807786 | BSL2v1c2 polypeptides The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related p... | 10/05/2010 |
| 7790428 | Essential fungal polypeptide, CaYDR341c, and methods of use thereof The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used f... | 09/07/2010 |
| 7767418 | Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e,... | 08/03/2010 |
| 7741025 | Method of diagnosing lung cancer using BGS42 The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relat... | 06/22/2010 |
| 7723479 | BSL3 polypeptides The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related p... | 05/25/2010 |
| 7714118 | Polynucleotides encoding the fkbB gene of the FK-520 polyketide synthase gene cluster Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open readin... | 05/11/2010 |
| 7705133 | Antibodies which bind variants of the TRP channel family member, LTRPC3 The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for produci... | 04/27/2010 |
| 7680601 | Design of polyketide synthase genes Methods for the computational analysis of polyketides and the computer-assisted design of PKS genes are facilitated by representing the structure of a polyketide and/or a PKS gene that encodes the PKS that produces the polyketide by alphanumeric symbols that facilit... | 03/16/2010 |
| 7671190 | Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthases and accessory proteins, and uses thereof The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains of geldanamycin and herbimycin polyketide synthases, polynucleotides t... | 03/02/2010 |
| 7667003 | Antibody directed to human mist (mast cell immunoreceptor signal transducer) The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, ex... | 02/23/2010 |
| 7642049 | Method for identifying HIV-1 protease inhibitors with reduced metabolic affects through detection of human resistin polymorphisms The invention provides a novel in vitro method for identifying HIV-1 protease inhibitors with reduced potential for inducing metabolic abnormalities. The invention further provides diagnostic methods for identifying patients who may be at risk of developing metaboli... | 01/05/2010 |
| 7635758 | Antibodies directed to G-protein coupled receptor HGPRBMY29sv1 The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2.... | 12/22/2009 |
| 7598348 | Adiponectin receptor variant, AdipoR2v2 The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, frag... | 10/06/2009 |
| 7598029 | Method for identifying HIV-1 protease inhibitors with reduced metabolic affects The invention provides a novel in vitro method for identifying HIV-1 protease inhibitors with reduced potential for inducing metabolic abnormalities. The invention further provides diagnostic methods for identifying patients who may be at risk of developing metaboli... | 10/06/2009 |
| 7572618 | Polynucleotides encoding novel PCSK9 variants The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention fu... | 08/11/2009 |
| 7541434 | Polypeptide for a TRP channel family member, TRP-PLIK2, and splice variants The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and T... | 06/02/2009 |
| 7541330 | Conjugates with reduced adverse systemic effects A conjugate of an active agent and a targeting moiety having affinity for a target cell, in which the active agent has been modified by attachment of a cell membrane-impermeabilizing group so that, if the active agent so modified is cleaved from the conjugate in the... | 06/02/2009 |
| 7537891 | Identification of polynucleotides for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in breast cells The present invention describes polynucleotides that have been discovered to correlate to the relative sensitivity or resistance of cells, e.g., breast cell lines, to treatment with compounds that interact with and modulate, e.g., inhibit, protein tyrosine kinases, ... | 05/26/2009 |
| 7531310 | Methods of diagnosing Crohn's disease by measuring expression level of RNA encoding human G-protein coupled receptor, HGPRBMY11 The present invention provides novel polynucleotides encoding HGPRBMY11 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of the HGPRBMY11 polypeptide, HGPRBMY11v1 and HGPRBMY11v2. Also provided are... | 05/12/2009 |
| 7521044 | Human histone deacetylase, HDAC9c The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vec... | 04/21/2009 |
| 7517957 | Human SLAP-2: a novel SH2/ SH3 domain-containing human SLAP homologue having immune cell-specific expression The present invention describes a newly discovered full-length polynucleotide encoding an SH2/SH3 domain-containing adapter protein, called hSLAP-2, cloned, isolated and identified. Also described are the hSLAP-2 polypeptide sequence, expression vectors, host cells,... | 04/14/2009 |
| 7517652 | Methods of diagnosing tumors using the G-protein coupled receptor (GPCR), RAI-3 The present invention describes a G-protein coupled receptor (GPCR) family member newly identified as being modified, e.g., phosphorylated, and associated with tyrosine phosphorylated activation complexes, following exposure of cells to smoke from tobacco burning su... | 04/14/2009 |
| 7504481 | TRP channel family member, LTRPC3 polypeptides The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e,... | 03/17/2009 |
| 7504211 | Methods of using EPHA2 for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in breast cells The present invention describes polynucleotides that have been discovered to correlate to the relative sensitivity or resistance of cells, e.g., breast cell lines, to treatment with compounds that interact with and modulate, e.g., inhibit, protein tyrosine kinases, ... | 03/17/2009 |
| 7482124 | Method of identifying a PPARgamma-agonist compound having a decreased likelihood of inducing dose-dependent peripheral edema The invention provides novel polynucleotides and polypeptides associated with the incidence of PPAR-agonist induced edema. The invention also provides polynucleotide fragments corresponding to the genomic and/or coding regions of these polynucleotides which comprise... | 01/27/2009 |
| 7465568 | Essential fungal polynucleotides, polypeptides, and methods of use The presnt invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used fo... | 12/16/2008 |
| 7459532 | Variants of the TRP channel family member, LTRPC3G The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for produci... | 12/02/2008 |
| 7452678 | Identification of biomarkers for liver toxicity The present invention relates to biomarker polypeptides, polynucleotides, and antibodies that have utility in predicting in vitro and/or in vivo hepatotoxicity of various drugs, compounds, or other therapeutic agents (i.e., test substances). Also related are screens... | 11/18/2008 |
| 7442770 | Human clnk-related polypeptide, MIST (Mast Cell Immunoreceptor Signal Transducer) The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, ex... | 10/28/2008 |
| 7442532 | Essential fungal CaYLR100w polypeptides, and methods of use The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used f... | 10/28/2008 |
