Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Number | Title | Issue Date |
| 6911214 | Flavoring systems for pharmaceutical compositions and methods of making such compositions A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one ... | 06/28/2005 |
| 6894171 | Polymorph of a pharmaceutical A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed. ... | 05/17/2005 |
| 6703403 | Method for improving pharmacokinetics A method is disclosed for improving the pharmacokinetics of a drug which is metabolized by cytochrome P450 monooxygenase.... | 03/09/2004 |
| 6608198 | Crystalline pharmaceutical New crystalline forms of lopinavir are disclosed.... | 08/19/2003 |
| 6531610 | Retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.... | 03/11/2003 |
| 6521651 | Pharmaceutical composition A liquid pharmaceutical composition providing improved oral bioavailability is disclosed for compounds which are inhibitors of HIV protease. In particular, the composition comprises a solution in a pharmaceutically acceptable organic solvent of (a) the HI... | 02/18/2003 |
| 6472529 | Retroviral protease inhibiting compounds A compound of the formula: ##STR1## is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.... | 10/29/2002 |
| 6458818 | Pharmaceutical composition A liquid pharmaceutical composition providing improved oral bioavailability is disclosed for compounds which are inhibitors of HIV protease. In particular, the composition comprises a solution in a pharmaceutically acceptable organic solvent of (a) the HI... | 10/01/2002 |
| 6372905 | Processes and intermediates for preparing retroviral protease inhibitors The instant invention provides processes and intermediates employed in the synthesis of ((2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2S-(1-tetrahy dropyrimid-2-onyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane and analogs thereof.... | 04/16/2002 |
| 6313296 | Retroviral protease inhibiting compounds A compound of the formula: ##STR1## is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.... | 11/06/2001 |
| 6284767 | Retroviral protease inhibiting compounds A compound of the formula: ##STR1## is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.... | 09/04/2001 |
| 6251906 | Retroviral protease inhibiting compounds The present invention discloses novel compounds, compositions, and methods for inhibiting retroviral proteases and in particular for inhibiting human immunodeficiency virus (HIV) protease. The present invention also relates to compositions and methods for... | 06/26/2001 |
| 6232333 | Pharmaceutical composition A liquid pharmaceutical composition providing improved oral bioavailability is disclosed for compounds which are inhibitors of HIV protease. In particular, the composition comprises a solution in a pharmaceutically acceptable organic solvent of (a) the HI... | 05/15/2001 |
| 6160122 | Process for the preparation of a disubstituted thiazole A process is disclosed for the preparation of N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-amino acid derivatives.... | 12/12/2000 |
| 6150530 | Retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.... | 11/21/2000 |
| 6037157 | Method for improving pharmacokinetics A method is disclosed for improving the pharmacokinetics of a drug which is metabolized by cytochrome P450 monooxygenase.... | 03/14/2000 |
| 6022989 | Process for the preparation of an activated amino acid A process is disclosed for the preparation of an N-acylated activated derivative of an amino acid or a salt thereof.... | 02/08/2000 |
| 5959118 | Process for the preparation of 5-hydroxymethylthiazoles The present invention discloses a process for the preparation of a hydroxymethylthiazole compound having formula 3: The process of the invention comprises reacting a halomethyl thiazole having the formula: ##STR1## with water, at an elevated temperat... | 09/28/1999 |
| 5948436 | Pharmaceutical composition A pharmaceutical composition is disclosed which comprises a solution of an HIV protease inhibiting compound in a pharmaceutically acceptable organic solvent comprising a pharmaceutically acceptable alcohol. The composition can optionally comprise a pharma... | 09/07/1999 |
| 5932766 | Process for the preparation of substituted keto-enamines The present invention discloses a process for the preparation of a compound having formula 4: ##STR1## The process comprises the step of reacting an enolate having the formula: ##STR2## with a Grignard reagent. The enolate salt is formed in situ... | 08/03/1999 |
| 5914332 | Retroviral protease inhibiting compounds A compound of the formula: ##STR1## is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.... | 06/22/1999 |
| 5892052 | Process for making retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.... | 04/06/1999 |
| 5886036 | Retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.... | 03/23/1999 |
| 5876749 | Pharmaceutical composition A pharmaceutical composition is disclosed which comprises a solution of an HIV protease inhibiting compound in a pharmaceutically acceptable organic solvent comprising a pharmaceutically acceptable alcohol. The composition can optionally comprise a pharma... | 03/02/1999 |
| 5846987 | Retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.... | 12/08/1998 |
| 5837873 | Intermediates of retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula A--X--B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for th... | 11/17/1998 |
| 5786500 | Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R6 and R7 are each hydrogen or R6 and R7 are independently se... | 07/28/1998 |
| 5773625 | Process for the preparation of disubstituted carbonates The present invention relates to a process for the preparation of cabonate compounds useful for the preparation of compounds which are human immunodeficiency virus (HIV) protease inhibitors. The compounds have formula I: ##STR1## wherein R9 | 06/30/1998 |
| 5725878 | Pharmaceutical composition comprising HIV protease inhibiting compounds A pharmaceutical composition is disclosed which comprises a solution of an HIV protease inhibiting compound in a pharmaceutically acceptable organic solvent comprising a pharmaceutically acceptable alcohol. The composition can optionally comprise a pharma... | 03/10/1998 |
| 5712400 | Process for preparation of 5-hydroxymethylthiazole A process for the preparation of 5-hydroxymethylthiazole comprises reacting a compound of the formula, ##STR1## with a carboxylic acid salt (optimally in the presence of a quaternary ammonium salt) and hydrolyzing the resulting ester. Subsequent ... | 01/27/1998 |
| 5712417 | Inhibitors of retroviral proteases The present invention relates to compounds of the formula I ##STR1## wherein A, Y, R2, R3, R4, R5, R6, l, m and the corresponding radicals labeled with * are defined as stated in the description,... | 01/27/1998 |
| 5696270 | Intermediate for making retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.... | 12/09/1997 |
| 5679797 | Retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.... | 10/21/1997 |
| 5674882 | Retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.... | 10/07/1997 |
| 5672706 | Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane A process is disclosed for the preparation of the substantially pure compound of the formula: ##STR1## comprising catalytic hydrogenation of a compound of the formula: ##STR2## wherein R6 and R7 are independently selected f... | 09/30/1997 |
| 5672605 | Macrolide immunomodulators Novel macrolide compounds of the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical c... | 09/30/1997 |
| 5670675 | Retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula A-X-B or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein X is a linking group; A is (1) substituted amino, (2) substituted carbonyl, (3) functionalized imino, (4) functionalized alkyl, (... | 09/23/1997 |
| 5659044 | Retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.... | 08/19/1997 |
| 5659045 | Retroviral protease inhibiting compounds A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.... | 08/19/1997 |
| 5654466 | Process for the preparation of a disubstituted 2,5-diamino-3-hydroxyhexane Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R6 and R7 are each hydrogen or R6 and R7 are independently se... | 08/05/1997 |
