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| Number | Title | Issue Date |
| 8029796 | Therapeutic anti-cytomegalovirus compounds The present invention provides synthetic compounds, antibodies that recognize and bind to these compounds, polynucleotides that encode these compounds, and immune effector cells raised in response to presentation of these epitopes. The invention further provides met... | 10/04/2011 |
| 7931030 | Regimens for intra-articular viscosupplementation The invention provides viscosupplementation methods for treating osteoarthritis and joint injury with HA-based viscosupplements, particularly viscosupplements with an intra-articular residence half-life shorter than 3 weeks. Viscosupplements for use in the methods o... | 04/26/2011 |
| 7727749 | Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids The present invention is directed to a regio- and stereoselective bioconversion of selected aliphatic dinitriles into corresponding cyanocarboxylic acids. More particularly, the present invention provides methods for the conversion of 2-isobutyl-succinonitrile into ... | 06/01/2010 |
| 7692014 | Inhibitors of the HIV integrase enzyme The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“H... | 04/06/2010 |
| 7655692 | Process for forming amorphous atorvastatin Forming amorphous atorvastatin comprises the steps of dissolving atorvastatin in a hydroxylic solvent, followed by rapidly evaporating the solvent. In another aspect, a composition comprises particles of amorphous atorvastatin and a core. ... | 02/02/2010 |
| 7622605 | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected... | 11/24/2009 |
| 7579471 | Tropane derivatives useful in therapy The present invention provides compounds of formula (I) wherein X, Y, R1, R2 and R3 are as defined hereinabove. The compounds of the present invention are modulators, especially anta... | 08/25/2009 |
| 7576097 | Tropane derivatives useful in therapy The present invention provides compounds of the formula: wherein R1 is C3-6 cycloalkyl optionally substituted by one or more fluorine atoms, or C1-6 alkyl optionally substituted by one or... | 08/18/2009 |
| 7557100 | Antibacterial agents Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical composition. ... | 07/07/2009 |
| 7534810 | Salt forms of [R—(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid Novel salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid characterized by their X-ray powder diffraction pattern and solid-state NMR spectra are described, as well as methods ... | 05/19/2009 |
| 7399773 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid and phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 07/15/2008 |
| 7371855 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 05/13/2008 |
| 7361771 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 04/22/2008 |
| 7309782 | Crystal forms of azithromycin The invention relates to novel crystal forms of azithromycin, an antibiotic useful in the treatment of infections. ... | 12/18/2007 |
| 7307156 | Crystal forms of azithromycin The invention relates to novel crystal forms of azithromycin, an antibiotic useful in the treatment of infections. ... | 12/11/2007 |
| 7081525 | Crystal forms of azithromycin The invention relates to novel crystal forms of azithromycin, an antibiotic useful in the treatment of infections. ... | 07/25/2006 |
| 7070811 | Directly compressible formulations of azithromycin The present invention relates to a dry blend, used for forming azithromycin tablets by direct compression, comprising non-dihydrate azithromycin and at least one pharmaceutically acceptable excipient. This invention also relates to an azithromycin tablet comp... | 07/04/2006 |
| RE39149 | Method of administering azithromycin An oral dosage form of azithromycin which does not exhibit an adverse food effect; Specific azithromycin oral dosage forms including tablets, powders for oral suspensions and unit dose packets; Methods of treating microbial infections with the dosage forms; And ther... | 06/27/2006 |
| 6984403 | Azithromycin dosage forms with reduced side effects The present invention is related to an oral dosage form comprising an effective amount of an alkalizing agent and an azithromycin multiparticulate wherein said multiparticulate comprises azithromycin, a glyceride which comprises glyceryl monobehenate, glyceryl dibeh... | 01/10/2006 |
| 6977243 | Crystal forms of azithromycin The invention relates to crystal forms of azithromycin, an antibiotic useful in the treatment of infections. ... | 12/20/2005 |
| 6835386 | Collar containing a novel gel formulation to control arthropod infestation of animals The present invention provides a device, preferably a collar or ear tag, capable of the controlled, sustained release of an effective amount of an active ingredient that can protect an animal against arthropod pests, comprising a reservoir containing a novel gel for... | 12/28/2004 |
| D499023 | Liquid measuring vessel | 11/30/2004 |
| 6825327 | Process for preparing 4″-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives The invention relates to processes for preparing compounds of formula 1 wherein R3 is as defined herein, and to pharmaceutically acceptable salts thereof, as well as intermediates us... | 11/30/2004 |
| 6673801 | Dihydroxyhexanoic acid derivatives Dihydroxyhexanoic acid derivatives of the general formula ##STR1## are useful to treat inflammation and other immune disorders.... | 01/06/2004 |
| 6670362 | Pyridazine endothelin antagonists Compounds of formula (I), pharmaceutical formulations thereof and the use of such compounds for treating endothelin mediated diseases or conditions are described herein. ##STR1## The compounds of the present invention have affinity for endothelin rec... | 12/30/2003 |
