Corneglio; Donald L. - US Patent Attorneys and Agents

Attorney: Corneglio; Donald L.

Number of patents: 66
Last date: June 23, 1998

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Number	Title	Issue Date
5770230	Method for preparing stabilized prostaglandin E1 A stable and lyophilized formulation of prostaglandin E-1 made by the process comprising a) dissolving PGE-1 in a solution of lactose and tertiary butyl alcohol wherein said tertiary butyl alcohol is present in an amount of from about 15% to about 33% vol...	06/23/1998
5741523	Stabilized prostaglandin E1 A stable and lyophilized formulation of prostaglandin E-1 made by the process comprising a) dissolving PGE-1 in a solution of lactose and tertiary butyl alcohol wherein said tertiary butyl alcohol is present in an amount of from about 15% to about 33% vol...	04/21/1998
5716970	Diuretic compound A diuretic compound of Formula I ##STR1## or pharmaceutically acceptable salt thereof where R1 is a C1-6 alkyl; R2 is halogen, C1-4 alkyl; and R3 is C1-4 alkoxy are disclosed, preferab...	02/10/1998
5716823	Human respiratory virus preparahons and processess This invention discloses compositions of DNA and proteins that are useful for preparing vaccines against human respiratory syncytial virus HRSV!. The DNA compositions include structural genes coding for native structural viral proteins and immunogenic f...	02/10/1998
5708018	2-aminoindans as selective dopamine D3 ligands Compounds and their pharmaceutically acceptable salts suitable for treating central nervous system disorders associated with the dopamine D3 receptor activity of Formula I: ##STR1## wherein R1 and R2 are independently chosen fro...	01/13/1998
5668157	Cyanoguanidines as K-channel blockers Cyanoguanidine compounds of formula (I) and its pharmaceutically acceptable acid addition salts wherein R1 is hydrogen or methyl; R2 is C1 -C6 alkyl, C2 -C6 alkenyl, C2 -C6...	09/16/1997
5652245	Heterocyclic amines having central nervous system activity Tricyclic nitrogen containing compounds, having anxiolytic and anti-depressant activity and central nervous system activity of the following structural formula: ##STR1## and pharmaceutically acceptable salts thereof wherein R1 and R2	07/29/1997
5650427	Centrally acting 6,7,8,9-tetrahydro-3H-benz(e) indole heterocyclics A compound of Formula I ##STR1## or pharmaceutically acceptable salts of Formula I, where R1 is H, C1 -C3 alkyl, --(CH2)n CONH2 where n is 2 to 6, (CH2)n -1-(4,4-dimethylpip...	07/22/1997
5643895	Phosphonoacetic esters and acids as anti-inflammatories Compounds useful in the treatment of inflammation structurally represented as Formula I ##STR1## one of X or Y is H and the other is selected from the group consisting of: ##STR2## or X and Y are taken together to form a ring selected from the g...	07/01/1997
5639778	Indoletetralins having dopaminergic activity A compound of formula (I) and pharmaceutically acceptable salts thereof, where Z is R3 and X and Y form (a), or X is R3 and Y and Z form (a) or (b); R1 and R2 are independently hydrogen, C1-6 alkyl, C...	06/17/1997
5635495	Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories Compounds useful in the treatment of inflammation structurally represented as ##STR1## wherein X,X1 and R groups are as herein defined....	06/03/1997
5633374	Pyrimidine, cyanoguanidines as K-channel blockers Pyrimidine-cyanoguanidine compounds of Formula I and its pharmaceutically acceptable acid addition salts ##STR1## wherein R1 is hydrogen or methyl; R2 is C1 -C6 alkyl, C2 -C6 alkenyl, C	05/27/1997
5610158	4-oxo- and 4H-imidazo(5,1-c)(1,4)benzoxazines useful as benzodiazepine receptor-binding agents Imidazo-benzoxazines of Formula (I) and pharmaceutically acceptable salts thereof. ##STR1## where Q is selected from (A) through (H) ##STR2## or pharmaceutically acceptable salts thereof wherein the R groups are as defined herein. The imida...	03/11/1997
5597816	Pyrazoloazepino substituted oximes useful as anti-atherosclerosis and anti-hypercholesterolemic agents Pyrazoloazepino-substituted oximes, having the formula ##STR1## wherein R is ##STR2## where R5 is --(CH2)c -- and c is 3-6 are disclosed. These compounds are useful for the treatment of atherosclerosis and h...	01/28/1997
5594024	Centrally actig substituted phenylazacycloalkanes A compound or Formula I ##STR1## or a pharmaceutically acceptable salt thereof wherein n is 1 or 2; R1 and R2 are independently H (provided only one is H at the same time), --OH, CN, CH2 CN, 2- or 4-CF3, CH...	01/14/1997
5593980	Arylmethylphosphonates and phosphonic acids useful as anti-inflammatory agents This invention provides a new use of acids, esters, and salts of arylmethylphosphonates of Formula I, ##STR1## or a phosphonic acid of Formula II ##STR2## and derivatives as anti-inflammatory and anti-arthritic agents. Representative compou...	01/14/1997
5578599	Stimulation of hair growth with minoxidil and a 5଱-reductase inhibitor An improved method and composition for promoting hair growth in mammals for treating various forms of alopecia or male pattern baldness comprising the concomitant administration of potassium channel openers, such as minoxidil, cromakalim, pinacidil, or a ...	11/26/1996
5567722	Cyanoguanidines as K-channel blockers Cyanoguanidine compounds of Formula I and its pharmaceutically acceptable acid addition salts ##STR1## wherein R1 is hydrogen or methyl; R2 is C1 -C6 alkyl, C2 -C6 alkenyl, C2 ...	10/22/1996
5565468	Pyridino substituted oximes useful as anti-atherosclerosis and anti-hypercholesterolemic agents Imidazopyridino- and pyrazolopyridino- substituted oximes are disclosed having the formulas ##STR1## wherein R1, R2, R3, R4, R5 and a are as described in the claims. for the treatment of atherosc...	10/15/1996
5565441	Phosphonoacetic esters and acids as anti-inflammatories Compounds useful in the treatment of inflammation structurally represented as Formula I ##STR1## one of X or Y is H and the other is selected from the group consisting of: ##STR2## or X and Y are taken together to form a ring selected from the g...	10/15/1996
5547950	Oxazolidinone antimicrobials containing substituted diazine moieties A compound of structural Formula I: ##STR1## or pharmaceutically acceptable salts thereof wherein: each n is independently 1 to 3; Y is chosen from a-n as defined herein; wherein each occurrence of said C.sub.1-6 alkyl may be substituted with one or ...	08/20/1996
5545755	Therapeutically useful 2-aminotetralin derivatives This invention is therapeutically useful 2-aminotetralins and pharmaceutically acceptable acid addition salts thereof of the formula ##STR1## R, R1 to R5 and p are as defined in the specification, these compounds are useful to t...	08/13/1996
5523318	Pyrrolidino-substituted oximes useful as anti-atherosclerosis and anti-hypercholesterolemic agents Pyrrolidinopyrazole-substituted oximes having the formula ##STR1## are disclosed wherein R1, R2, R3, R4, R5 and a are as described in the claims for the treatment of atherosclerosis and hyperchol...	06/04/1996
5523403	Tropone-substituted phenyloxazolidinone antibacterial agents A novel class of phenyloxazolidinone antibacterial agents which have, as their salient structural feature, an appended substituted tropone moiety, are described. Intermediates and processes for the preparation of these antibiotics are also disclosed. Thes...	06/04/1996
5521154	Imidoester cross-linked hemoglobin compositions An imidoester, cross-linked hemoglobin composition useful in the transport of oxygen to living cells and being essentially free of any impurities, a P50 of at least 13mm Hg and predominantly in tetraruer form. Preferably, the cross-linked hemoglobin compo...	05/28/1996
5510537	Preparation of alpha, beta-unsaturated enones A process for oxidizing silyl enone ethers to alpha, beta-unsaturated enodes having the formulas ##STR1## which comprises reacting the appropriate silyl enone ether with a radical generated by the metal catalyst decomposition of a peroxide compositio...	04/23/1996
5500417	Arylmethylphosphonates and phosphonic acids useful as anti-inflammatory agents This invention provides a new use of acids, esters, and salts of arylmethylphosphonates of Formula I, ##STR1## or phosphonic acid derivatives of Formula II ##STR2## as anti-inflammatory and anti-arthritic agents. Representative compounds in...	03/19/1996
5491236	(1,2N) and (3,2N)-carbocyclic-2-amino tetralin derivatives This invention is therapeutically useful tetralins and pharmaceutically acceptable acid addition salts thereof of the formula ##STR1## wherein R, R1 and A are as defined in claim 1. These compounds are useful to treat central nervous syste...	02/13/1996
5488059	Treatment of erectile dysfunction A method to induce or enhance an erection or treat erectile dysfunction through the administration of a pyridylguanidine compound, preferably, N-cyano-N'(1,1-dimethyl propyl)-N"-3-pyridinyl guanidine, in low doses to the penis. Administration can be by in...	01/30/1996
5462947	Centrally acting substituted phenylazacycloalkanes A compound of Formula I ##STR1## or a pharmaceutically acceptable salt thereof wherein n is 1 or 2; R1 and R2 are independently H (provided only one is H at the same time), --OH, CN, CH2 CN, 2-- or 4--CF3, ...	10/31/1995
5461061	Centrally acting 6,7,8,9-tetrahydro-3H-benz(E)indole heterocyclics A compound of Formula I ##STR1## or pharmaceutically acceptable salts of Formula I, where R1 is H, C1 -C3 alkyl, --(CH2)n CONH2 where n is 2 to 6, (CH2)n -1-(4,4-dimethylpip...	10/24/1995
5430048	Spirocyclic benzopyran imidazolines Spiro- [4H- 1 -benzopyran-4,4'-5'H-imidazol]-5'-ones of the Formula 1: ##STR1## wherein R1 is H, R2 F, Cl, Br, CF3, CF3 O, CN, NO2, R2 SO2, R2 NHSO2, R...	07/04/1995
5430176	Intermediate used for the preparation of deferoxamine A method for preparing deferoxamine and a composition of Formula I X--Ph--CH2 --O--C(O)--NH--(CH2)4 --CH.dbd.NOR wherein X is a C1 -C4 alkyl, --O(C1 -C4 alkyl), a halogen or hydrogen,; R i...	07/04/1995
5373012	5-fluoro-2,4,6-pyrimidinetriamine compounds A 5-fluoro-minoxidil compound and compositions are disclosed which are useful in the treatment of hair growth and cardiovascular disorders. The 5-fluoro-minoxidil compounds have been shown to have increased transdermal transport than minoxidil and therefo...	12/13/1994
5362855	Imidoester cross-linked hemoglobin compositions An imidoester, cross-linked hemoglobin composition useful in the transport of oxygen to living cells and being essentially free of any impurities, a P50 of at least 13 mm Hg and predominantly in tetramer form. Preferably, the cross-linked hemoglobin compo...	11/08/1994
5306830	Substituted 3-amino chromans The present invention is directed to novel chromane derivatives substituted in the 3-position by a substituted amino moiety and substituted on the aromatic ring with one or two substituents. The novel chromane derivatives have useful CNS properties. ...	04/26/1994
5302599	Therapeutically useful heterocyclic indole compounds A therapeutically useful compound of formula I ##STR1## or pharmaceutically acceptable salts thereof where A and B are oxygen, sulfur or CH2, X is an amine moiety as defined herein and R1 and R2 are as defined herein ...	04/12/1994
5302613	Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones This invention relates to compounds of Formula I ##STR1## which are useful as antiatherosclerotic agents and inhibitors of cell proliferation for the treatment of proliferative diseases. In addition, various compounds of Formula I are useful inhibito...	04/12/1994
5298498	Phosphonic acid derivatives useful as anti-inflammatory agents Novel acids, esters, and salts of phenyl, naphthyl, quinoxalinyl, and biphenyl bisphosphonic acids and 1,2-oxaphosphepins are described. These compounds are useful as antiinflammatory and anti-arthritic agents. Also described are known compounds of the ph...	03/29/1994
5273975	Heterocyclic amines having central nervous system activity Tricyclic nitrogen containing compounds, having central nervous system activity of the following structural formula: ##STR1## and pharmaceutically acceptable salts thereof wherein R1, R2, and R3 are independently hydr...	12/28/1993

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Attorney: Corneglio; Donald L.