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| Number | Title | Issue Date |
| 7578809 | Surface modified viscoelastics for ocular surgery Disclosed are surface modified viscoelastics and methods of performing viscosurgery using polymer-containing irrigating solution to reduce cohesiveness of the viscoelastic agent at the interface, thereby improving its performance by reducing the occurrence of uninte... | 08/25/2009 |
| 7012090 | Pyranoindoles for treating glaucoma Substituted pyranoindoles useful for lowering and controlling IOP and glaucoma are disclosed. ... | 03/14/2006 |
| 6960579 | Serotonergic 5HTreceptor compounds for treating ocular and CNS disorders Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for... | 11/01/2005 |
| 6949525 | Use of a mixture of sodium hyaluronate and chondroitin sulfate for the treatment of osteoarthritis This invention is related to the use of the composition formed by sodium hyaluronate and sodium chondroitin sulfate for the treatment of chondral lesions in osteoarthritis, and to the use of such composition in the manufacture of a product for such treatment. ... | 09/27/2005 |
| 6906044 | Regeneration of articular cartilage damaged by grade I and II osteoarthritis by means of the intraarticular application of a mixture of sodium hyaluronate and chondroitin sulfate in a gel vehicle Methods of treating osteochondral lesions by the intraarticular application of a mixture of sodium hyaluronate and chondroitin sulfate are disclosed. ... | 06/14/2005 |
| 6828444 | Process for use in 11-oxa prostaglandin synthesis Novel processes useful in the preparation of 11-oxa prostaglandin analogs are disclosed. ... | 12/07/2004 |
| 6806285 | 5-Hydroxyl indole derivatives for treating glaucoma Novel 3-(2-aminopropyl)-H-indol-5-ols useful for lowering and controlling IOP and treating glaucoma are disclosed. ... | 10/19/2004 |
| 6723748 | Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension Disclosed is the use of cloprostenol and fluprostenol analogues in combination with carbonic anhydrase inhibitors for the treatment of glaucoma and ocular hypertension and ophthalmic compositions therefor. ... | 04/20/2004 |
| 6680339 | 15-fluoro prostaglandins as ocular hypotensives 15-fluoro substituted analogs of PGF2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.... | 01/20/2004 |
| 6649655 | 11ଲ-fluoro 15ଲ-hydroxy PGF2 analogs as FP receptor antagonists Methods and compositions for the antagonism of FP receptor-mediated biological responses are disclosed.... | 11/18/2003 |
| 6649653 | 15-fluoro prostaglandins as ocular hypotensives 15-Fluoro substituted analogs of PGF2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.... | 11/18/2003 |
| 6645978 | Lipoxin A4 and its analogs for the treatment of dry eye Ophthalmic compositions containing Lipoxin A4 and its analogs and methods of their use for treating dry eve are disclosed.... | 11/11/2003 |
| 6646001 | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension Disclosed are methods and compositions for the treatment of glaucoma and ocular hypertension, comprising the administration of a prostaglandin FP receptor agonist and a prostaglandin synthesis inhibitor.... | 11/11/2003 |
| 6576663 | 6-Keto prostaglandin F1 and analogs for treating dry eye Compositions and methods for the treatment of dry eye and related diseases utilizing 6-keto-PGF1 and its analogs are disclosed.... | 06/10/2003 |
| 6531614 | Method of prostaglandin synthesis Methods of synthesizing 9-Halo-13,14-dihydroprostaglandins useful in the treatment of glaucoma and ocular hypertension are disclosed. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.... | 03/11/2003 |
| 6495608 | Methods of performing surgery with galactomannan polymers and borate The present invention is directed to viscoelastic systems comprising a combination of a galactomannan polysaccharide containing composition and borate containing composition. The two compositions gel or partially gel upon combination. The present inventio... | 12/17/2002 |
| 6492417 | 11-deoxy-16-fluoro-PGF2 analogs as FP receptor antagonists Methods and compositions for the antagonism of FP receptor-mediated biological responses are disclosed.... | 12/10/2002 |
| 6462080 | Prostaglandin E receptor agonists for treatment of dry eye The present invention relates to use of prostaglandin E receptor agonists and partial agonists to stimulate mucin secretion to treat dry eye, keratoconjunctivitis, Sjogren's syndrome and related ocular surface diseases.... | 10/08/2002 |
| 6441196 | Processes and novel intermediates for 11-oxa prostaglandin synthesis Novel processes and intermediates useful in the preparation of 11-oxa prostaglandin analogs are disclosed.... | 08/27/2002 |
| 6441033 | 11ଲ-fluoro 15ଲ-hydroxy PGF2 analogs as FP receptor antagonists Methods and compositions for the antagonism of FP receptor-mediated biological responses are disclosed.... | 08/27/2002 |
| 6417228 | 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension 13-Aza analogs of PGF2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.... | 07/09/2002 |
| 6403590 | Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia Isoquinolinesulfonyl compounds are used in ophthalmic compositions to treat glaucoma or other ischemic-borne ocular disorders such as retinopathies or optic neuropathies. These compounds vasodilate ocular blood vessels, lower IOP and prevent or reduce the... | 06/11/2002 |
| 6388128 | Stannane synthesis of prostanoids The present invention is directed to novel methods of prostanoid synthesis. Specifically, the invention is directed to the addition of alpha chains to prostanoids using cis-alkenylstannane intermediates.... | 05/14/2002 |
| 6376541 | Upregulation of endogenous prostaglandins to lower intraocular pressure A method of lowering intraocular pressure (IOP) employs an upregulating agent that induces increased prostaglandin synthesis in the eye. The method of treatment entails administering to the eye of a mammal in need thereof a prostaglandin upregulating agen... | 04/23/2002 |
| 6353000 | 11-halo prostaglandins for the treatment of glaucoma or ocular hypertension A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I: ##STR1##... | 03/05/2002 |
| 6353014 | 15-ketal postaglandins for the treatment of glaucoma or ocular hypertension A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I: ##STR1##... | 03/05/2002 |
| 6344478 | Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension Disclosed is the use of cloprostenol and fluprostenol analogues in combination with carbonic anhydrase inhibitors for the treatment of glaucoma and ocular hypertension and ophthalmic compositions therefor.... | 02/05/2002 |
| 6344477 | Prostaglandin e agonists for treatment of dry eye Compositions and methods for the treatment of dry eye and related diseases utilizing EP4 receptor agonists are disclosed.... | 02/05/2002 |
| 6344581 | Method of prostaglandin synthesis Methods of synthesizing 9-Halo-13,14-dihydroprostaglandins useful in the treatment of glaucoma and ocular hypertension are disclosed. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.... | 02/05/2002 |
| 6342524 | Use of non-steroidal anti-inflammatory agents in combination with compounds that have FP prostaglandin agonist activity to treat glaucoma and ocular hypertension Disclosed are methods and compositions for the treatment of glaucoma and ocular hypertension, comprising the administration of a prostaglandin analog and a prostaglandin synthesis inhibitor.... | 01/29/2002 |
| 6280199 | Antibody teaching aid A teaching aid for use in facilitating the study and understanding of antibodies and antigens is disclosed. The teaching aid comprises models demonstrating how the variable regions of both the light and heavy chains of the antibody protein permit both the... | 08/28/2001 |
| 6271224 | Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia The present invention relates to the field of ophthalmology. In particular the invention relates to the field of ocular disorders including visual field loss and glaucoma using an isoquinolinesulfonyl compound, which lowers intraocular pressure (IOP) and ... | 08/07/2001 |
| 6235779 | Use of cis-Ɗ4 analogs of prostaglandins as ocular hypotensives Cis-Ɗ4 analogs of prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.... | 05/22/2001 |
| 6232344 | 13-Oxa prostaglandins for the treatment of glaucoma and ocular hypertension 13-Oxa analogs of certain prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.... | 05/15/2001 |
| 6211226 | 11-Aza prostaglandins for the treatment of glaucoma and ocular hypertension 11-aza analogs of PGF2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.... | 04/03/2001 |
| 6197812 | Substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives Substituted tetrahydrofuran analogs of prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.... | 03/06/2001 |
| 6184250 | Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension Disclosed is the use of cloprostenol and fluprostenol analogues and combinations thereof with other medicaments for the treatment of glaucoma and ocular hypertension and ophthalmic compositions therefor. Also disclosed are methods of treating optic nerve ... | 02/06/2001 |
| 6172109 | 13-Thia prostaglandins for use in glaucoma therapy 13-thia prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising said prostaglandins.... | 01/09/2001 |
| 6169111 | Conformationally rigid aryl prostaglandins for use in glaucoma therapy Conformationally rigid aryl prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic pharmaceutical compositions comprising said prostaglandins.... | 01/02/2001 |
| 6160013 | 14-aza prostaglandins for the treatment of glaucoma and ocular hypertension 14-Aza analogs of PGF2, PGD2, and PGE2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.... | 12/12/2000 |
