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Attorney: Cooley Godward Castro Huddleson & Tatum


Number of patents: 97
Last date: November 18, 1997

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NumberTitleIssue Date
5688784Method of suppressing appetite with vanadium complexes
There are provided vanadium compositions for use in the treatment of hypertension, obesity and diabetes, in particular improved oral compositions comprising oxovanadium (IV) chelates of monoprotic, bidentate oxygen, oxygen and oxygen, nitrogen coordinatin...
11/18/1997
5629414Diagnostic genes for toxoplasmosis
Genetic material encoding p30 and B1 peptides of Toxoplasma gondii has been isolated and characterized. This genetic material allows the production of peptides for use in diagnosis or immunization or can itself be directly used in hybridization assays....
05/13/1997
5605825Human PAK65
A novel human serine protein kinase, human p21-protein activated serine kinase p65 protein, referred to as hPAK65, and methods for its preparation and use are provided. Nucleic acids encoding hPAK65 and methods for their use in preparing hPAK65 as well as...
02/25/1997
5603685Inflatable vaginal pessary
A pessary device, comprising a first inflatable chamber adapted to fit in the vestibule of the vaginal cavity of a human when inflated, wherein the chamber compresses the urethra of the human when inflated; an anchor member adapted to snugly fit in the va...
02/18/1997
5597719Interaction of RAF-1 and 14-3-3 proteins
Intermolecular interactions between Raf-1 and human 14-3-3 proteins which regulate Raf activity are identified. Compositions and method for identifying novel drugs which modulate Raf activity in vivo are provided....
01/28/1997
5571903Auto-ligating oligonucleotide compounds
The invention provides compositions and a method for delivering an antisense compound or probe to a target polynucleotide. The compositions of the invention comprise a plurality of compounds each having an oligonucleotide moiety from about 4 to 12 monomer...
11/05/1996
5571677Convergent synthesis of branched and multiply connected macromomolecular structures
The invention provides methods and compositons for convergent synthesis of branched polymers useful as molecular probes. The invention also includes several novel branched polymeric structures particularly useful for detecting target polynucleotides. Bran...
11/05/1996
5567592Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal
A screening method for the identification of bioenhancers that increase the bioavailability of an orally administered pharmaceutical compound through the inhibition of P-glycoprotein transport activity in the gut of a mammal is disclosed. These compounds ...
10/22/1996
5559114Treatment of autoimmune disease using 2-amino purine derivatives
A method for treating autoimmune disease in a mammalian subject, particularly a human, which method comprises administering a therapeutically effective amount of certain 2-amino purine compounds to the subject. The compounds particularly useful are antivi...
09/24/1996
5556872Histamine derivatives useful as immunomodulators
The present invention provides histamine derivatives and methods for using histamine derivatives as immunomodulators and in immunotherapeutics. More specifically the present invention provides methods for inhibiting at least a portion of an an antigen spe...
09/17/1996
5547868Cholesterol disposal fusion enzymes
Fusion enzymes having multiple segments of different biological activity including one segment having P450scc activity and at least one segment having electron-transfer activity for transferring electrons to P450scc are described along with genetic constr...
08/20/1996
5530890High performance, low cost microprocessor
A microprocessor (50) includes a main central processing unit (CPU) (70) and a separate direct memory access (DMA) CPU (72) in a single integrated circuit making up the microprocessor (50). The main CPU (70) has a first 16 deep push down stack (74), which...
06/25/1996
5527790Bis(maltolato)oxovanadium compositions for the treatment of elevated blood sugar
There are provided vanadium compositions for use in the treatment of hypertension, obesity and diabetes, in particular improved oral compositions comprising oxovanadium (IV) chelates of monoprotic, bidentate oxygen, oxygen and oxygen, nitrogen coordinatin...
06/18/1996
5527610Elastomeric polypeptide matrices for preventing adhesion of biological materials
The invention provides a bioelastomer comprising tetrapeptide and/or pentapeptide monomeric units of the formula: R1 PGR2 Gn wherein R2 is a peptide-producing residue of alanine or glycine; P is a peptide-producing r...
06/18/1996
5519004Elastomeric polypeptide matrices for preventing adhesion of biological materials
The invention provides a bioelastomer comprising tetrapeptide and/or pentapeptide monomeric units of the formula: R1 PGR2 Gn wherein R1 is a peptide-producing residue of alanine or glycine; P is a peptide-producing r...
05/21/1996
5517125Reusable die carrier for burn-in and burn-in process
A reusable carrier (10) for temporarily holding an integrated circuit (12) during burn-in and electrical test includes a base (14) and a lid (16) attached to the base (14) by hinges (18). A flexible substrate (19) is attached to the base (14) with a suita...
05/14/1996
5510261Method of controlling the degradation of glycoprotein oligosaccharides produced by cultured Chinese hamster ovary cells
A neuraminidase enzyme with unusually high activity under extracellular culture conditions has been discovered in Chinese hamster ovary (CHO) cells and other types of cells. By affecting the neuraminidase activity of the cell culture, the degradation of g...
04/23/1996
5496724Genes encoding platelet aggregation inhibitors
An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samp...
03/05/1996
5480776Method for prediction of premature labor
A method for detecting the onset of labor in a patient, which comprises analyzing a body fluid of the patient for estriol concentration; correlating the concentration with a standard value; and relating a higher concentration of estriol relative to the st...
01/02/1996
5479268User interface for television schedule system
Screen (10) for a user interface of a television schedule system and process consists of an array (24) of irregular cells (26), which vary in length, corresponding to different television program lengths of one half hour to one-and-one half hours or more....
12/26/1995
5479266User interface for television schedule system
Screen (10) for a user interface of a television schedule system and process consists of an array (24) of irregular cells (26), which vary in length, corresponding to different television program lengths of one half hour to one-and-one half hours or more....
12/26/1995
5473060Oligonucleotide clamps having diagnostic applications
Compounds referred to herein as oligonucleotide clamps are provided that stably bind to target polynucleotides in a sequence-specific manner. The oligonucleotide clamps comprise one or more oligonucleotide moieties capable of specifically binding to a tar...
12/05/1995
5472844Methods of detection of Toxoplasma gondii P22 gene
Genetic material encoding the P22 peptide of Toxoplasma gondii has been isolated and characterized. This genetic material allows the production of peptides for use in diagnosis or immunization or can itself be directly used in hybridization assays....
12/05/1995
5471382Medical network management system and process
In a medical network management system (NMS) (20), health plan beneficiaries access a team of health care professionals over the telephone to help them assess their health needs and select appropriate care. The NMS (20) has a patient assessment component ...
11/28/1995
5466469Granular drug delivery system
A novel granular drug delivery system having a gel-forming dietary fiber that can be made into a an orally-ingestible dispersion by admixture with a liquid that can deliver an effective dose of a pharmaceutically-active compound. The granular drug deliver...
11/14/1995
5463911Actuation apparatus for a gearshift sleeve in a stepped automotive gearbox
A gearshift sleeve actuating apparatus for a stepped automotive gearbox is disclosed. The apparatus comprises a shift rod which can be displaced along its axis. A shift fork and an engaging piece or driver are rigidly arranged on the shift rod. The appara...
11/07/1995
5456985Microcapsules of oily liquid
The present invention relates to micro-capsules constituted by a solid envelope consisting of a layer of coating materials including at least one gastro-resistant polymer, said solid envelope containing an oily liquid....
10/10/1995
5440749High performance, low cost microprocessor architecture
A microprocessor (50) includes a main central processing unit (CPU) (70) and a separate direct memory access (DMA) CPU (72) in a single integrated circuit making up the microprocessor (50). The main CPU (70) has a first 16 deep push down tack (74), which ...
08/08/1995
5437990Selective amplification of target polynucleotide sequences
A method is provided for multiplying the number of copies of a target polynucleotide sequence comprising a series of primer hybridization, extending, and denaturing steps to provide an intermediate double-stranded DNA molecule containing a promoter sequen...
08/01/1995
5429510High-density interconnect technique
A high density interconnect system (30) employs contact fingers (32) on both surfaces (34) and (36) of burn-in PCB (38), feed-through PCB (40) and driver PCB (42). Each of the PCBs (38), (40) and (42) has a card-edge connector (44), (46) and (48). The fee...
07/04/1995
5417972Method of killing B-cells in a complement independent and an ADCC independent manner using antibodies which specifically bind CDIM
Methods are provided for inducing cell death in B-cells, including neoplastic B-cells, by employing reagents that bind to a B-cell epitope. Particularly, antibodies specific for the marker can be administered to a host to induce death in B-cells to which ...
05/23/1995
5415995Diagnostic peptides of human papilloma virus
A series of seventeen synthetic peptides which are capable of raising antibodies specific for certain desired human papilloma virus (HPV) are useful in diagnosis and therapy of conditions associated with HPV infection....
05/16/1995
5399464Triamine positive photoresist stripping composition and post-ion implantation baking
A stripping composition for removing positive organic photoresist from a substrate, such as a semiconductor wafer, contains a triamine, such as diethylene triamine, and a nonpolar or polar organic solvent, such as N-methyl pyrrolidone. This composition wi...
03/21/1995
5395928Chromatographic separation of phosphorothioate oligonucleotides
A method is provided for the preparation and/or analysis of synthetic phosphorothioate and -dithioate oligonucleotides. In particular, the method permits separation of fully sulfurized phosphorothioate or -dithioate oligonucleotides from incompletely sulf...
03/07/1995
5393602Superabsorbent materials and uses thereof
Polymeric materials having an inverse temperature transition, particularly bioelastic polymers comprising monomeric units selected from the group consisting of bioelastic pentapeptides, tetrapeptides, and nonapeptides, have been found to have controllable...
02/28/1995
5393427Process for the biological treatment of wastewater
A process and installation for the removal of organic matter, phosphate ions and nitrogenous compounds from sewage wastewater. The installation comprises a raw sewage feed line 12 shown feeding into a primary separation basin 14. The primary separation ba...
02/28/1995
5370135Use of estriol measurement to monitor tocolytic therapy
A method of monitoring tocolytic therapy, which comprises determining a first concentration of estriol in a body fluid of a pregnant patient undergoing or diagnosed as a candidate for undergoing treatment with a tocolytic agent and, based on the value of ...
12/06/1994
5367823Apparatus for cut flower storage and display
An improved cut flower storage and display assembly is provided having a plurality of vertically spaced storage and display containers and including integral container dividers formed by the configuration of the vertically spaced containers. The assembly ...
11/29/1994
5362625Methods and compositions for enzyme complementation assays using the omega region of ଲ-galactosidase
The use of omega-acceptor and omega-donor polypeptides (comprising about two-thirds and one-third of the ଲ-galactosidase molecule amino and carboxyl termini, respectively), prepared by recombinant DNA techniques, DNA synthesis, or chemical polypepti...
11/08/1994
5344783Platelet aggregation inhibitors
An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of the PAI in a wide range of snake venom s...
09/06/1994
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