Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 4833270 | Process for preparing 2-chloro-4,5-difluorobenzoic acid This disclosure describes a novel process for preparing 2-chloro-4,5-difluorobenzoic acid which is useful in the preparation of 7-(substituted)piperazinyl-1-substituted-6-fluoro-1,4-dihydro-4-oxo-3-quin oli necarboxylic acid antibacterial agents.... | 05/23/1989 |
| 4820738 | 1,4-bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.... | 04/11/1989 |
| 4814350 | Method of treating diabetes with 5-[1-hydroxy-2-(isopropylamino)ethyl]anthranilonitrile This disclosure describes pharmaceutical compositions of matter containing 5-[1-hydroxy-2-(isopropylamino)ethyl]anthranilonitrile and the method of treating diabetes therewith.... | 03/21/1989 |
| 4808730 | Synthesis of cisplatin analogs This disclosure sets forth a novel process for producing cisplatin analogs which possess antitumor activity.... | 02/28/1989 |
| 4808586 | Substituted benzimidazoles and benzothidiazoles having anti-asthmatic and/or anti-inflammatory activities This disclosure describes novel substituted 2-phenyl-1H-benzimidazoles and 2-phenyl-1H-benzimidazole-4,7-diones and novel 5-chloro-6-(4-substituted-1-piperazinyl)-2,1,3-benzothiadiazole-4,7-diones ; all of which are highly active as anti-asthmatic and anti... | 02/28/1989 |
| 4808579 | Novel monocycle ଲ-lactam antibacterials The disclosure describes (S)-3-[2-(2-amino-4-thiazolyl)]-(Z)-2-methoxyiminoacetylamino-2-oxo-1-azet idinyliminoacetic acid and (S)-3-[2-(2-amino-4-thiazolyl)]-(Z)-2-methoxyiminoacetylamino-2-(S)-methyl -4-oxo-1-azetidinyliminoacetic acid and the cation... | 02/28/1989 |
| 4771061 | Substituted piperazine-1,4-naphthalenediones useful for treating asthma, allergic diseases and/or inflammation This disclosure describes certain substituted piperazine-1,4-naphthalenediones useful as anti-asthmatic agents.... | 09/13/1988 |
| 4732895 | -[5-methyl-2-(pyridinyl)-1H-imidazol-4-yl]substituted-1-p iperazineethanols useful for treating hypertension This disclosure describes novel substituted -[5-methyl-2-pyridyl-1H-imidazol-4-yl]-1-piperazineethanols which possess hypotensive activity.... | 03/22/1988 |
| 4732970 | Antitumor amino acid and peptide derivatives of 1,4-bis(aminoalkyl and hydroxy-aminoalkyl)amino)-5,8-dihydroxyanthraquinones Antitumor amino acid and peptide derivatives of 1,4-bis[(aminoalkyl and hydroxyaminoalkyl)amino]-5,8-dihydroxyanthraquinones.... | 03/22/1988 |
| 4716157 | Heterocyclic-1,2-diamine platinum complexes This disclosure describes platinum complexes of heterocyclic-1,2-diamines which possess the property of inhibiting the growth of tumors in mammals.... | 12/29/1987 |
| 4715993 | Process for preparing certain 1,4-di[ω-(2-hydroxyethylamino)alkylamino]anthraquinone free bases This disclosure describes a novel process for liberating the free bases of certain 1,4-di[ω-(2-hydroxyethylamino)alkylamino]anthraquinones from the salts thereof.... | 12/29/1987 |
| 4703115 | Platinum complexes of diamino-dideoxy sugars and di- or tricarboxylic acids Platinum complexes and Di- or Tricarboxylic acids which is then reacted with the appropriate di- or tricarboxylic acid in aqueous medium.... | 10/27/1987 |
| 4696935 | Method of treating transplanted tumors and modulating the immune response This disclosure describes compositions of matter useful for inducing the regression of transplanted tumors in warm-blooded animals and for enhancing the immune system, and the method of treatment of transplanted tumors and enhancing the immune response in... | 09/29/1987 |
| 4696940 | Method for treating hypertension using 3-(4-imidazolylmethylene)-carbazic and dithiocarbazic acid esters This disclosure describes compositions of matter containing substituted 3-(4-imidazolymethlene)carbazic and dithiocarbazic acid esters and the method of treating hypertension therewith.... | 09/29/1987 |
| 4692449 | Substituted quinolinediones This disclosure describes novel 6-(4-substituted-1-piperazinyl)-5,8-quinolinediones, 7-(4-substituted-1-piperazinyl)-5,8-quinolinediones, and 6-(4-substituted-1-piperazinyl)-5,8-quinoxalinediones which possess activity an anti-asthmatic and anti-alle... | 09/08/1987 |
| 4686102 | Multivalent pneumococcal vaccine and preparation thereof A multivalent pneumococcal vaccine consisting of immunogenic amounts of purified pneumococcal capsular polysaccharide (substantially absent "C" polysaccharide) of pneumococcal types (Danish designation) 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14,... | 08/11/1987 |
| 4686220 | Substituted 2-[b-substituted-amino)-ethylamino]-1,4-naphthalenediones for treating asthma, allergic diseases and inflammation in warm-blooded animals This disclosure describes certain substituted piperazine-1,4-naphthalenediones useful as anti-asthmatic agents.... | 08/11/1987 |
| 4670458 | Hydroxylated 1,2-diaminocyclohexane platinum complexes This disclosure describes platinum complexes of 3ଲ, 4-diamino-1,2-cyclohexanediol which possess the property of inhibiting the growth of tumors in mammals.... | 06/02/1987 |
| 4670421 | Antiatherosclerotic silanes This invention is concerned with novel 4-[(trialkylsilyl)alkylamino]phenyl compounds and their use as antiatherosclerotic agents.... | 06/02/1987 |
| 4626503 | Antitumor agents LL-D491941, LL-D49194ଲ1, LL-D49194ଲ2, LL-D49194ଲ3, LL-D49194γ, LL-D49194δ, LL-D49194&3xb5;, LL-D49194.xi., LL-D49194η, LL-D49194ω1, LL-D49194ω2, and LL-D49194ω3 Antitumor agents LL-D49194댑, LL-D49194댡, LL-D49194댢, LL-D49194댣, LL-D49194γ, LL-D49194δ, LL-D49194&3xb5;, LL-D49194.xi., LL-D49194η, LL-D49194ω, LL-D49194ω2 and LL-D49... | 12/02/1986 |
| 4623662 | Antiatherosclerotic ureas and thioureas This invention is concerned with ureas and thioureas which may be represented by the formula: ##STR1## wherein X represents at least one substituent selected from the group consisting of (C1 -C4)alkyl, (C1 -C4 | 11/18/1986 |
| 4614618 | 1,4-bis(substituted-amino)-5,8-dihydroxy anthraquinones and leuco bases thereof This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.... | 09/30/1986 |
| 4613611 | Method of treating diabetes mellitus using arylglyoxals A method of treating diabetes mellitus using arylglyoxals which are known compounds.... | 09/23/1986 |
| 4610981 | N-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)-alkyl]benzenesulfonamides and thromboxane synthetase/antihypertensive compositions This invention concerns novel N-[(1H-imidazol-1-yl), (1H-1,2,4-triazol-1-yl) and (3-pyridyl)alkyl]benzenesulfonamides which are useful as inhibitors of thromboxane synthetase enzyme and/or as antihypertensive agents.... | 09/09/1986 |
| 4603145 | Antiatherosclerotic diphenyl alkanamides This disclosure describes novel diaryl-alkanamides. These compounds are useful as pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial wall of mammals.... | 07/29/1986 |
| 4592876 | Arylglyoxals Arylglyoxals which are new compounds, active as hypoglycemic agents.... | 06/03/1986 |
| 4593130 | Synthesis of 10-hydroxymethyl-9-anthraldehyde This disclosure describes the catalyzed rearrangement of trans-dispiro (oxirane-2,9-(10'H)-anthracene)-10',2"-oxirane to 10-hydroxymethyl-9-anthraldehyde.... | 06/03/1986 |
| 4587331 | Platinum complexes of polyhydroxylated alkylamines and 2-polyhydroxylated alkyl-1,2-diaminoethanes Platinum complexes of polyhydroxylated alkylamines and 2-polyhydroxylated alkyl-1,2-diaminoethanes useful for inducing regression and/or palliation of cancer diseases in mammals.... | 05/06/1986 |
| 4576943 | Pyrazolo[1,5-a]pyrimidines This disclosure describes certain pyrazolo[1,5-a]pyrimidines useful as hypotensive and/or anxiolytic agents, or as agents for the treatment of cognitive and related neural behavioral problems in mammals.... | 03/18/1986 |
| 4577018 | 2,3-Diamino-substituted-4(3H)-pyrimidinones and platinum chelates Platinum chelates of 2,3-diamino-substituted-4(3H)-pyrimidinones which are useful as antitumor agents.... | 03/18/1986 |
| 4576957 | N-(Substituted phenyl)-N'-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]ureas N-(Substituted phenyl)-N'-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]ureas which are inhibitors of thromboxane synthetase enzyme.... | 03/18/1986 |
| 4568687 | N-[2-4-(1H-Imidazol-1-yl)alkyl]-arylamides and pharmaceutical compositions This disclosure describes novel N-[ω-(1H-imidazol-1-yl)alkyl]arylamides which possess the property of inhibiting the enzyme thromboxane synthetase and are also useful in the treatment of hypertension and myocardial ischemia.... | 02/04/1986 |
| 4562189 | Pyrazolylpiperazines This disclosure describes novel pyrazolylpiperazines useful as hypotensive agents in mammals and as intermediates for the preparation of certain pyrazolo[1,5-a]pryrimidines.... | 12/31/1985 |
| 4558163 | Process for preparing 9,10-anthracenedicarboxaldehyde This disclosure describes a novel process for the preparation of 9,10-anthracenedicarboxaldehyde by the oxidation of 9,10-bis(chloromethyl)anthracene.... | 12/10/1985 |
| 4550169 | Platinum chelates of 2-hydrazino-azoles This disclosure describes platinum chelates of 2-hydrazino-1-aza (or 1,3-diaza,1-oxa-3-aza or 1-thia-3-aza)-1-cyclo-alkenes which possess activity as antitumor agents.... | 10/29/1985 |
| 4550166 | (Pyridinyl)-1,2,4-triazolo[4,3-a]pyridines This disclosure describes novel substituted 1,2,4-triazolo[4,3-a]pyridines which possess anxioltic activity.... | 10/29/1985 |
| 4546181 | Platinum chelates of 3-amino-substituted-[1,2,4]triazolo[1,5-a]-pyrimidin-7(3H)-ones Platinum chelates of 3-amino-substituted-[1,2,4]-triazolo[1,5-a]pyrimidin-7(3H)-ones which are antitumor agents.... | 10/08/1985 |
| 4544759 | Platinum complexes of antitumor agents The compounds are the class of substituted hydrazine carboximidamides which are useful for inducing the regression and/or palliation of leukemia and related cancers in mammals when administered in amounts of from about one mg. to about 1.2 gm. per square ... | 10/01/1985 |
| 4540788 | Schiff bases of [(aminoalkyl or substituted aminoalkyl)amino]-9,10-anthracenediones This disclosure describes novel Schiff bases of 1,4-bis[(ω-aminoalkyl)amino]-9,10-anthracenediones and leuco bases thereof which are useful as chelating agents and for inducing regression of leukemia and/or inhibiting tumor growth in mammals.... | 09/10/1985 |
| 4540519 | 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof This disclosure describes symmetrical 1,4-bis-(substituted-amino)-5,8-hydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.... | 09/10/1985 |
