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| Number | Title | Issue Date |
| 8163979 | Antifungal plant proteins and methods of their use DNA constructions that provide for production of potent antifungal proteins in transgenic plants and transformed yeast cells are described. Methods of using the DNA constructs to produce transgenic plants that inhibit growth of plant pathogenic fungi are also disclo... | 04/24/2012 |
| 8153760 | Rhinovirus vaccines The present invention relates generally to peptide vaccines. More specifically, the present invention relates to vaccines against rhinoviruses and other related and non-related pathogenic animal viruses. In addition, the present invention relates generally to method... | 04/10/2012 |
| 7691813 | Cyclic peptide CXCR4 antagonists Provided are lactam-cyclized peptide CXCR4 antagonists useful in the treatment of cancers, rheumatoid arthritis, pulmonary fibrosis, and HIV infection. ... | 04/06/2010 |
| 7619096 | 3-Aminopyrrolidines as inhibitors of monoamine uptake The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful for the inhibition of the uptake of one or more physiologically active monoamines (serotonin, norepinep... | 11/17/2009 |
| 7619069 | Antibodies to TGF-beta 1 TGF-beta 1 binding compositions and reagents related thereto are provided. Methods of using such compositions for therapeutic purpose are also provided. ... | 11/17/2009 |
| 7601700 | Modulation of eIF4E expression Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E ex... | 10/13/2009 |
| 7595315 | Morpholine derivatives as norepinephrine reuptake inhibitors Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system. ... | 09/29/2009 |
| 7582608 | Selective VPAC2 receptor peptide agonists The present invention encompasses peptides that selectively activate the VPAC2 receptor and are useful in the treatment of diabetes. ... | 09/01/2009 |
| 7541344 | Modulation of survivin expression Compounds and compositions are provided for modulating the expression of survivin. The compounds, exemplified by those acting through an RNAi antisense mechanism of action, include double-stranded and single-stranded constructs, as well as siRNAs, canonical siRNAs, ... | 06/02/2009 |
| 7494651 | TGF-β binding antibodies The present invention provides very high affinity antibodies, or antigen-binding fragments thereof, that neutralize mature human TGF-β1, TGF-β2, and TGF-β3. The antibodies of the invention are useful for treating cell proliferative disorders in a mammal. ... | 02/24/2009 |
| 7488728 | Pyridinylmorpholine derivatives The invention relates to compounds of formula (I): wherein R, R1, R2 and X are defined herein, their preparation, and their use as pharmaceuticals. | 02/10/2009 |
| 7479271 | Humanized anti-ghrelin antibodies Humanized antibodies, or antigen-binding portions thereof, that preferentially bind acylated ghrelin with respect to unacylated ghrelin, are disclosed. These molecules have high affinity and a slow off rate for acylated ghrelin, and neutralize acylated ghrelin activ... | 01/20/2009 |
| 7432280 | 3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful for the inhibition of the uptake of one or more physiologically active monoamines (serotonin, norepinep... | 10/07/2008 |
| 7425544 | Modulation of eIF4E expression Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E ex... | 09/16/2008 |
| 7423037 | Morpholine derivatives as norepinephrine reuptake inhibitors Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system. ... | 09/09/2008 |
| 7384941 | 2-(phenoxymethyl)-and 2-(phenylthiomethyl)-morpholine derivatives for use as selective norepinephrine reuptake inhibitors Compounds of formula (I): wherein A is S or O; R is H; Ar is an optionally substituted phenyl group; X is an optionally substituted phenyl group, a C1-C4 alkyl, a C3... | 06/10/2008 |
| 7384983 | Inhibitor of monoamine uptake The present invention provides compounds and methods for the inhibition of monoamine uptake in mammals. ... | 06/10/2008 |
| 7354920 | Aryl and heteroaryl morpholine derivatives Compounds of formula (I) wherein Rx is H; Ry is H or C1-C4 alkyl; each Rz is independently H or C1-C4 alkyl; X represents O; Y represents OH or OR; R is C... | 04/08/2008 |
| 7307069 | Antisense oligonucleotide modulation of STAT3 expression Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression a... | 12/11/2007 |
| 7288530 | Antisense modulation of survivin expression Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compound... | 10/30/2007 |
| 6919188 | Pseudomycin production by Pseudomonas syringae The present invention is directed to a family of unique antimycotic lipopeptide compounds produced by Pseudomonas viridiflava. The lipopeptides are effective against both human and plant fungal pathogens, and are typically characterized by their ability to in... | 07/19/2005 |
