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| Number | Title | Issue Date |
| 8168169 | Methods and compositions for the treatment of medical disorders In general, the invention relates to marrow-derived adult progenitor cells (MAPCs) and their use in methods of treating various medical disorders, typically caused by or involving loss of cells or loss of cell function. These cells, when administered, e.g., intranas... | 05/01/2012 |
| 8138314 | Compositions and methods of monoclonal and polyclonal antibodies specific for T cell subpopulations The invention provides compounds and methods for the ex vivo or in vivo expansion of NK T cells, CD1d-reactive T cells, and JαQ+ T cells, and the modulation of their activities. These compounds and methods have diagnostic and therapeutic applications. | 03/20/2012 |
| 7830069 | Arrayed ultrasonic transducer An ultrasonic transducer comprises a stack having a first face, an opposed second face and a longitudinal axis extending therebetween. The stack comprises a plurality of layers, each layer having a top surface and an opposed bottom surface, wherein the plurality of ... | 11/09/2010 |
| 7504495 | Quencher compositions comprising anthraquinone moieties The present invention provides novel quencher composition comprising anthraquinone quencher moieties. The anthraquinone quencher moieties are useful as quencher labels when attached to biomolecules such as natural or modified polynucleotides, oligonucleotides, nucle... | 03/17/2009 |
| 7413739 | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments. ... | 08/19/2008 |
| 7326685 | Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof Disclosed are peptide agents and uses thereof that are analogs of biologically active peptides such as somatostatin and bombesin. The compounds of the invention have the general formula X-Y-Z-Q, where X is a cytotoxic agent, therapeutic agent, detectable label or ch... | 02/05/2008 |
| 7297538 | Encapsulated cell indicator system The invention features an encapsulated cell indicator system that includes (a) indicator cells having a signal-responsive element operably linked to a reporter gene; (b) encapsulating material; and (c) a permeable membrane. In this encapsulated cell indicator system... | 11/20/2007 |
| 7297847 | Amino acid-enriched plant protein reserves, particularly lysine-enriched maize γ-zein, and plants expressing such proteins An oligonucleotide including at least one concatenation coding for a polypeptide of formula (P—K)n, wherein n is an integer of at least 2, P is a proline amino acid residue, K is a lysine amino acid residue, and the sign “—” is a bond, particularl... | 11/20/2007 |
| 7217794 | Compounds and methods for treatment of thrombosis The present invention provides compounds that inhibit Factor XIa and methods of preventing or treating undesired thrombosis by administering a compound of the invention to a mammal. The invention also provides three-dimensional structures of Factor XIa and methods f... | 05/15/2007 |
| 7208576 | Non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof The invention features non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof. ... | 04/24/2007 |
| 7208268 | Differential phage capture proteomics Disclosed herein are methods for identifying, isolating and comparing proteins and other biomolecules differing between two complex biological samples using affinity chromatography and phage display techniques. ... | 04/24/2007 |
| 7202333 | DNA encoding IgE Receptor α-subunit or fragment thereof A cDNA sequence encoding the α-subunit of human mast cell IgE surface receptor or an IgE binding fragment thereof. ... | 04/10/2007 |
| 7199376 | Method and apparatus for monitoring a condition in chlorophyll containing matter A method of monitoring health in chlorophyll containing matter comprises exposing the matter to a light source to cause chlorophyll to fluoresce and emit a fluorescence signal. Any changes in a parameter indicative of changes in the intensity of the fluorescence sig... | 04/03/2007 |
| 7189503 | Characterization of individual polymer molecules based on monomer-interface interactions The invention relates to a method for detecting a double-stranded region in a nucleic acid by (1) providing two separate, adjacent pools of a medium and a interface between the two pools, the interface having a channel so dimensioned as to allow sequential monomer-b... | 03/13/2007 |
| 7186816 | Photolyase nucleic acids The invention generally provides a novel approach to identifying Enterococcal virulence factors and for identifying compounds for treating bacterial pathogenesis. The invention further provides Enterococcal virulence factors, which serve as targets for drug discover... | 03/06/2007 |
| 7091333 | Antisense IAP nucleobase oligomers and uses thereof The present invention features nucleobase oligomers that hybridize to IAP polynucleotides, and methods for using them to enhance apoptosis and treat proliferative diseases. ... | 08/15/2006 |
| 7056275 | Radiotherapy The invention provides a method of radiation treatment of a human or non-human mammalian subject which comprises administering to said subject a therapeutically, prophylactically or pain-palliating amount of a bone-targeting complex of an alpha-particle emitting tho... | 06/06/2006 |
| 7026466 | Serotonin-gated anion channel Disclosed is a novel serotonin-gated anion channel that is permeable to chloride ions. Also disclosed are methods for the screening of therapeutics useful for treating serotonin-mediated cellular responses and conditions, as well as diagnostic methods for identifyin... | 04/11/2006 |
| 6960562 | Tribonectin polypeptides and uses thereof The invention features a lubricating polyeptide and methods of lubricating joints or other tissues by administering the polypeptide systemically or directly to tissues. ... | 11/01/2005 |
| 6946544 | XAF genes and polypeptides: methods and reagents for modulating apoptosis The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis. ... | 09/20/2005 |
| 6905670 | Methods of screening compounds useful for prevention of infection or pathogenicity Screening procedures are disclosed for identifying compounds useful for inhibiting fungal infection or pathogenicity. Methods are also disclosed for identifying fungal pathogenic virulence factors. ... | 06/14/2005 |
| 6897339 | Process for the production of high purity iohexol Purification process of iohexol comprising the treatment of said product with 1-methoxy-2-propanol either alone or mixed with other solvents. ... | 05/24/2005 |
| 6884784 | Diagnosis and management of infection caused by chlamydia The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae. The invention is based, in part, upon the discovery that a combination of agents directed toward the vario... | 04/26/2005 |
| 6849259 | Polyclonal antibody composition for treating allergy A pharmaceutical composition for treating allergy is described. The composition comprises as an active ingredient a recombinant polyclonal antibody or a mixture of different monoclonal antibodies capable of reacting with or binding to an allergen together with one o... | 02/01/2005 |
| 6841145 | CeSERT genes, proteins, and modulatory compounds The invention features substantially pure nucleic acid sequences encoding wild-type or mutant serotonin retake transporter (SERT) polypeptides, as well as the polypeptides themselves. The invention also features methods for identifying modulators of the biological a... | 01/11/2005 |
| 6841532 | Peptides and their use to ameliorate cell death There is disclosed novel peptides, fragments or analogues thereof and polynucleotides encoding the same, obtained from streptokinase suitable for use in the amelioration of cell death and methods related thereto. ... | 01/11/2005 |
| 6818757 | Cardiac-cell specific enhancer elements and uses thereof The invention features cardiac cell-specific enhancer elements derived from Csx/Nkx2.5 regulatory regions. These enhancer elements are useful, for example, for (i) regulating gene expression in cardiac cells, (ii) inducing stem cells (e.g., embryonic stem cells or b... | 11/16/2004 |
| 6797473 | Methods and compounds for modulating male fertility The invention features methods and reagents useful for the treatment of excessive or insufficient apoptosis in cells, and, particularly, in germ-line cells. The invention is useful in treating testicular cancers, cancers of germ-line cells, cancers in non-germ-line ... | 09/28/2004 |
| 6730662 | Adenovirus E4 proteins for inducing cell death The invention features E4orf4-encoding nucleic acids, pharmaceutical compositions and expression vectors containing the same, and methods for their use. E4orf4-encoding nucleic acids include (i) nucleic acids capable of hybridizing at high stringency to the compleme... | 05/04/2004 |
| 6723893 | Mice having a mutant SOD-1-encoding transgene Disclosed is the family of genes responsible for the neurodegenerative diseases, particularly Amyotrophic Lateral Sclerosis. Methods and compounds for the diagnosis, prevention, and therapy of the disease are also disclosed. ... | 04/20/2004 |
| 6716967 | Rupestris stem pitting associated virus nucleic acids, proteins, and their uses This invention relates to purified monoclonal antibodies that specifically bind to a Rupestris stem pitting associated virus coat protein or coat protein polypeptide, and methods of detecting a Rupestris stem pitting associated virus. ... | 04/06/2004 |
| 6709866 | Methods for enhancing survival of a neuron NAIP and IAP polypeptides prevent neuronal cell death caused by ischemia, neurodegenerative conditions, and axotomy. The invention provides methods for neuroprotection by the prevention of cell death and kits and methods for the identification of neuroprotective the... | 03/23/2004 |
| 6685652 | Method for determining fluctuation in attentional state and overall attentional state The invention provides methods for determining shifts in the attentional state of a subject. These methods are useful for diagnosing subjects with a psychological or behavioral disorder. The invention also features methods for determining the effect of a ... | 02/03/2004 |
| 6663850 | Inhibition of ceramide for the prevention and treatment of oral mucositis induced by antineoplastic drugs or radiation Intervention for oral mucosal injury secondary to chemotherapy or radiation based on the inhibition in the synthesis of ceramide, blockage of its activity, or its digestion.... | 12/16/2003 |
| 6664239 | Diagnosis and management of infection caused by Chlamydia The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae. The invention is based, in part, upon the discovery that a combination of agents directed toward the various ... | 12/16/2003 |
| 6632602 | Plant sugar sensors and uses thereof Disclosed are methods and genes for manipulating the sugar-sensing capabilities of a plant, involving reducing or increasing the level of a hexokinase protein in a transgenic plant.... | 10/14/2003 |
| 6630445 | Recombinant alpha-fetoprotein for treating cancers Disclosed is a method of inhibiting a neoplasm in a mammal, the method includes administering to the mammal a therapeutically effective amount of recombinant human alpha-fetoprotein.... | 10/07/2003 |
| 6569853 | Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders The invention features a method for treating a patient having a cancer or other neoplasm, by administering to the patient (i) chlorpromazine or a metabolite or analog thereof; and (ii) pentamidine or a metabolite or analog thereof simultaneously or within... | 05/27/2003 |
| 6566065 | Method of diagnosing schizophrenia by detecting a mutation in the (MTHFR) gene The invention features methods for diagnosing subjects at risk for or suffering from a disease or disorder, such as a psychosis. Methods are also provided for selecting a preferred therapy for a particular subject or group of subjects.... | 05/20/2003 |
| 6554439 | Illumination apparatus for simulating dynamic light conditions An apparatus for generating artificial light that closely simulates the intensity and spectrum of natural light and other dynamic light conditions. The apparatus includes a collection of light sources of various colors which are controlled by a computer. ... | 04/29/2003 |
