Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 7947449 | Methods of diagnosing pre-eclampsia or eclampsia Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the... | 05/24/2011 |
| 7943394 | Method and device for high sensitivity detection of the presence of DNA and other probes The present invention provides a method for capacitive detection of the presence of target sample on a substrate, which comprises the steps of: binding a target sample to selective binding sites on the substrate, the target sample being directly or indirectly labele... | 05/17/2011 |
| 7942828 | Method for determining fluctuation in attentional state and overall attentional state The invention provides methods for determining shifts in the attentional state of a subject. These methods are useful for diagnosing subjects with a psychological or behavioral disorder. The invention also features methods for determining the effect of a therapy on ... | 05/17/2011 |
| 7939079 | species and cultivation thereof The present invention relates to the isolation and cultivation of “Candidatus Helicobacter suis” and isolates of “Candidatus Helicobacter suis” obtainable by these methods. The present invention further relates to the use of these bacteria for ... | 05/10/2011 |
| 7935786 | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis The invention is directed to a pharmacologically active peptide conjugate having a reduced tendency towards enzymatic cleavage comprising a pharmacologically active peptide sequence (X) and a stabilising peptide sequence (Z) of 4-20 amino acid residues covalently bo... | 05/03/2011 |
| 7935497 | Protease detection A method of detecting a protease in a sample. The method comprises providing an analyte degradable by the protease. The analyte is contacted with the sample. The degradation products of the analyte or the residual undegraded analyte is detected in a binding assay. | 05/03/2011 |
| 7928189 | PCSK9 polypeptide fragment The present invention provide PCSK9 polypeptides, fragments thereof and methods of modulating PCSK9 phosphorylation and low density lipoprotein degradation. ... | 04/19/2011 |
| 7919510 | Substituted benzimidazole compounds with dual NOS inhibitory activity and mu opioid agonist activity The present invention relates to benzimidazole compounds having dual nitric oxide synthase (NOS) inhibitory activity and agonist activity at the mu-opioid receptor, to pharmaceutical and diagnostic compositions containing them, and to their medical use, particularly... | 04/05/2011 |
| 7915265 | Combinations for the treatment of immunoinflammatory disorders The invention features pharmaceutical compositions that include dipyridamole and a corticosteroid. ... | 03/29/2011 |
| 7915038 | Method for producing a recipient-specific tissue transplant or tissue implant The method represents a further development of a cell-colonization process, in which biological cells are colonized on a synthetic or natural tissue matrix in order to obtain a tissue implant or tissue transplant. The growth of the cells, which in general come from ... | 03/29/2011 |
| 7914579 | Tissue engineered tendons and ligaments Connective tissue, including neo-tendons and ligaments, has been constructed using biodegradable synthetic scaffolds seeded with tenocytes. The scaffolds are preferably formed from biodegradable fibers formed of a polymer such as polyglycolic acid-polylactic acid co... | 03/29/2011 |
| 7910547 | Tissue regeneration method The invention relates to the use of haematopoietic growth factors, in particular erythropoietin (EPO) and thrombopoietin (TPO), or derivatives, analogues or parts thereof, for promoting structural tissue regeneration. ... | 03/22/2011 |
| 7910544 | Conformationally constrained parthyroid hormone (PTH) analogs The invention provides novel P1R polypeptide antagonists. These antagonists contain amino acid substitutions at selected positions in truncated PTH and PRHrP polypeptides and function by binding selectively to the juxtamembrane (“J”) domain of the receptor. The ... | 03/22/2011 |
| 7910324 | Method of screening for compounds which affect the processing of EphA4 by γ-secretase The present invention provides a method of screening for compounds which affect the processing of EphA4 by γ-secretase, which includes the following steps: (i) contacting a first biological composition containing γ-secretase or a... | 03/22/2011 |
| 7910138 | Use of a polyphenol for the treatment of a cancerous or precancerous lesion of the skin A method for treating cancerous or pre-cancerous lesions of the skin by administering a pharmaceutically effective amount of a polyphenol to a patient as well as to the production of a medicament thereto is described herein. ... | 03/22/2011 |
| 7910098 | Anti-VEGF antibodies The invention herein provides isolated antibodies that bind to VEGF. The invention further provides methods of making anti-VEGF antibodies, and polynucleotides encoding anti-VEGF antibodies. ... | 03/22/2011 |
| 7910030 | Process and apparatus for continuous wet granulation of powder material An apparatus for wet granulating a powder material comprises: —a barrel having a granulation chamber and being provided with a first inlet (1) for receiving said powder material and for supplying it to said granulation chamber and with a second inlet (2 | 03/22/2011 |
| 7906520 | Methods for treating pain The present invention features methods and compositions for preventing, reducing, or treating a traumatic, metabolic or toxic peripheral nerve lesion or pain including, for example, neuropathic pain, inflammatory and nociceptive pain by administering to a mammal in ... | 03/15/2011 |
| 7906483 | Method for treating transplant rejection Compositions and methods for treating transplant rejection in a mammalian transplant recipient are provided. The method involves administering a therapeutically effective amount of Serp-1, its analogs, and biologically active fragments thereof in combination with an... | 03/15/2011 |
| 7906480 | Use of a parathyroid hormone peptide analogs for the treatment of vaginal atrophy The invention features methods for the treatment of vaginal atrophy by administering a parathyroid hormone peptide or peptide analog and formulations thereof. ... | 03/15/2011 |
| 7901358 | High frequency array ultrasound system A system for acquiring an ultrasound signal comprises a signal processing unit adapted for acquiring a received ultrasound signal from an ultrasound transducer having a plurality of elements. The system is adapted to receive ultrasound signals having a frequency of ... | 03/08/2011 |
| 7899220 | Time-dependent three-dimensional musculo-skeletal modeling based on dynamic surface measurements of bodies Active contour models and active shape models were developed for the detection of the kinematics landmarks on sequential back surface measurements. The anatomical landmarks correspond with the spinous process, the dimples of the posterior superior iliac spines (PSIS... | 03/01/2011 |
| 7897610 | Use of benzo[c]quinolizinium derivatives for the treatment of diseases that are linked to smooth muscle cell constriction The invention relates to the use of benzo[c]quinolizinium derivatives for treating diseases that are linked to smooth muscle cell constriction, such as hypertension and asthma. ... | 03/01/2011 |
| 7892769 | Processing of EphA4 polypeptide by γ-secretase activity The present invention provides EphA4 polypeptides which encode EphA4 fragments cleaved by γ-secretase, especially intracellular fragments of such cleaved fragments, polynucleotides which encode such polypeptides, and antibodies specific to such polypeptides. Also d... | 02/22/2011 |
| 7892566 | Immunogenic constructs The present invention relates to molecules, which can be used to induce a therapeutic or prophylactic immune response against MAP. In particular, the present invention relates to polypeptides comprising an alipC polypeptide sequence, a gsd polypeptide sequence, a pl... | 02/22/2011 |
| 7888338 | 7-(2-cyclohexylidene-ethylidene)-spiro[4.5]decanes The present invention relates to 7-(2-cyclohexylidene-ethylidene)-spiro[4.5]-decanes, compositions which comprise said 7-(2-cyclohexylidene-ethylidene)-spiro[4.5]-decanes, and methods for treating diseases, illnesses, and the like with said 7-(2-cyclohexylidene-ethy... | 02/15/2011 |
| 7884125 | Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invent... | 02/08/2011 |
| 7884078 | CPG15 compounds as insulin receptor and insulin-like growth factor receptor agonists Disclosed herein are CPG15 and CPG15-2 compounds and inhibitors that act as agonists and antagonists of the insulin receptor and insulin-like growth factor receptors, and the use of such compositions for the treatment of insulin and insulin-like growth factor-relate... | 02/08/2011 |
| 7884077 | Methods for the treatment of mood disorders The invention features methods of treating mood disorders, such as manic disorders, and stabilizing moods by administering a kappa agonist or partial agonist to a subject in need thereof. ... | 02/08/2011 |
| 7846738 | Study of polymer molecules and conformations with a nanopore The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., ... | 12/07/2010 |
| 7846433 | Methods of treating pre-eclampsia and eclampsia Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the... | 12/07/2010 |
| 7875704 | Anti-PLGF antibody The present invention provides novel monoclonal antibodies directed to PlGF and fragments and derivatives thereof, more particularly to humanized antibodies and fragments thereof for use in the treatment and/or prevention of pathological angiogenesis. ... | 01/25/2011 |
| 7863254 | Compounds for the treatment of psychiatric or substance abuse disorders The invention provides methods for treating or preventing psychiatric and substance abuse disorders, involving administration of a therapeutically-effective amount of a cytosine-containing or cytidine-containing compound, creatine-containing compound, adenosine-cont... | 01/04/2011 |
| 7863045 | Isolation of skeletal precursor cells Cartilage-derived morphogenetic protein CDMP-1 or a transforming growth factor β having at least 80% homology with CDMP-1, or a factor co-expressed and/or co-detectable therewith, is used as a marker of skeletal precursor cells from any part of a mammalian body. | 01/04/2011 |
| 7860552 | CNS assay for prediction of therapeutic efficacy for neuropathic pain and other functional illnesses In general, the invention features methods for identifying therapeutic interventions for functional illnesses, e.g., neuropathic pain or depression, and methods for identifying markers for functional illnesses by employing an acute painful stimulus or other stimulus... | 12/28/2010 |
| 7858662 | Medicament for the treatment of viral skin and tumour diseases The invention relates to a medicament containing a compound of general formula (1), where R1=independently, a straight or branched, saturated, singly- or multiply-unsaturated, optionally substituted C11-C21 alkyl, alkylene or alkynyl... | 12/28/2010 |
| 7858089 | Antibodies binding to the A2 domain of FVIII and inhibiting coagulation activity The present invention relates to new antibodies and fragments and derivatives thereof. These antibodies bind to the A2 domain of Factor VIII (FVIII) of the coagulation pathway and inhibit the coagulation activity of FVIII. The antibodies are particularly suited for ... | 12/28/2010 |
| 7857978 | Membrane for filtering of water Disclosed are novel water membranes comprising lipid bilayers incorporating functional aqua-porins. The lipid bilayers are arranged in sandwich structures including hydrophilic or hydro-phobic support materials. Also disclosed are water purification devices/systems,... | 12/28/2010 |
| 7854717 | Method and compositions for treatment of cancers A method to treat cancer uses ultrapheresis, refined to remove compounds of less than 120,000 daltons molecular weight, followed by administration of replacement fluid, to stimulate the patient's immune system to attack solid tumors. In the preferred embodiment, the... | 12/21/2010 |
| 7850959 | Methods and compositions for treating conditions involving abnormal angiogenesis The present invention features methods and compositions for preventing, reducing, or treating hypoxia and pathological disorders involving abnormal angiogenesis (e.g., conditions involving decreases or increases in blood flow, respectively). Where an increase in ang... | 12/14/2010 |
