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| Number | Title | Issue Date |
| 6150532 | Modulators of proteins with phosphotyrosine recognition units The present invention relates to novel protein tyrosine phosphatase modulating compounds having the general structure shown in Formula (A1), to methods for their preparation, to compositions comprising the compounds, to their use for treatment of human an... | 11/21/2000 |
| 6107274 | Piperazines as inhibitors of fructose-1,6-bisphosphatase (FBPase) Compounds of formula A are disclosed: ##STR1## wherein R1 is aralkyl or cycloalkyl; R2 is cycloalkylmethyl, alkyl, or aralkyl; R3 is hydrogen, alkyl, substituted phenyl (including p-phenoxy-phenyl), or fluorene; R | 08/22/2000 |
| 5965558 | Modulators of proteins with phosphotyrosine recognition units Y--X--C(R').dbd.C(R")COOR"' (A1) The present invention relates to novel protein tyrosine phosphatase modulating compounds having the general structure shown in Formula (A1), to methods for their preparation, to compositions comprising the compounds, to th... | 10/12/1999 |
| 5866569 | Naphthalenedione nitric oxide synthase (NOS) inhibitors There are disclosed methods useful for the inhibition of inducible nitric oxide synthase by the adminstration of a compound of the formula I:. when R2 is H then R1 is selected from the group consisting of: 1) aryl,--NH--C0 -C | 02/02/1999 |
| 5840721 | Imidazole derivatives as MDR modulators The present invention relates to polysubsituted imidazole having formula 1 ##STR1## These compounds are useful for restoring the sensitivity of multidrug resistant cells to cancer chemotherapeutic agents.... | 11/24/1998 |
| 5770620 | Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors The present invention provides novel protein tyrosine phosphatase modulating compounds having an aryl acrylic acid structure, compositions comprising the compounds, and methods of making and using the same.... | 06/23/1998 |
| 5756527 | Imidazole derivatives useful as modulators of multi drug resistances The present invention relates to imidazole derivatives having formula 1 ##STR1## wherein: R1 is selected from the group consisting of: mono-,di-,and tri-substituted phenyl or thienyl, the substituents are selected from the group consisting... | 05/26/1998 |
| 5753687 | Modulators of proteins with phosphotryrosine recognition units Y--X--C(R').dbd.C(R")COOR'" (A1) The present invention relates to novel protein tyrosine phosphatase modulating compounds having the general structure shown in Formula (A1), to methods for their preparation, to compositions compr... | 05/19/1998 |
| 5723451 | Nitric oxide synthase (NOS) inhibitors There are disclosed methods useful for the inhibition of inducible nitric oxide synthase by the adminstration of a compound of the Formula I: ##STR1## to a patient in need of such inhibition such as hypotension, inflammation, autoimmune diseases and ... | 03/03/1998 |
| 5700826 | 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance This invention relates to compounds of Formula 1 which are pharmacologically useful for the treatment of cancer through sensitization of multi-drug resistant cancer cells to chemotherapeutic agents. ##STR1## wherein R1, R2, R | 12/23/1997 |
| 5444047 | Treatment of arthritic and post-surgical orthopedic conditions with Insulin-like Growth Factor-I A method is disclosed which comprises a method for reducing atrophy in at least one striated skeletal muscle of an individual, comprising administering a therapeutically effective amount of Insulin-like Growth Factor-I (IGF-I) to said individual.... | 08/22/1995 |
| 5420000 | Heat fixable high energy radiation imaging film Described is a radiation sensitive imaging film containing a heat fixable radiation sensitive element, e.g., a diacetylene, of the formula: R--C.tbd.C--C.tbd.C--R', where R and R' are, e.g., both --CH2 --O--CONH--(CH2)5 CH... | 05/30/1995 |
| 4837304 | Inhibitor of ribonucleotide reductase A series of oligopeptides each of which contains a D-amino acid has been found to inhibit the activity of the ribonucleotide reductase enzyme of herpes simplex virus in vitro thereby inhibiting viral replication.... | 06/06/1989 |
| 4814432 | Inhibitor of ribonucleotide reductase A series of peptides has been found to inhibit the activity of the ribonucleotide reductase enzyme of herpes simplex virus in vitro thereby inhibiting viral replication.... | 03/21/1989 |
| 4812442 | Tripeptide renin inhibitors Enzyme tripeptides of the formula: ##STR1## and analogs thereof which inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhib... | 03/14/1989 |
| 4744929 | Support device for a packed column A support device for supporting a packing material in a packed column having an upwardly flowing gas and a downwardly flowing liquid. The device comprises a plate having a plurality of formations. Each formation comprises spaced side walls connected by an... | 05/17/1988 |
| 4741745 | Process for separation of carbon dioxide from other gases Diisopropyl ethers of oligomers of ethylene glycol having between 2 and 8 ethylene glycol moieties and an average molecular weight between 190 and 300, are more useful physical absorption solvents for the separation of acid gases than are dimethyl, diethy... | 05/03/1988 |
| 4722203 | Stitch-bonded fabrics for reinforcing coated abrasive backings Stitch bonded fabrics were found to be suitable substrates for coated abrasives when the fabric has a strength in the warp direction of at least 30 dekanewtons (daN) per centimeter (cm) of width, a fill yarn cover factor of at least 40%, and stitch yarns ... | 02/02/1988 |
| 4605631 | Advanced preparation of ceramic powders Sub-micron sized powders of the ceramic metal oxides such as zirconia, alumina, titania, etc. are produced by precipitation upon mixing aqueous or aqueous/organic solutions of salts of the corresponding metal(s) with substantially 95% solutions of ammonia... | 08/12/1986 |
| 4603109 | Method and apparatus for contacting reactants in chemical and biological reactions The present invention is directed to novel methods and apparatus for conducting chemical and biological reactions. A reactor is provided that includes a reaction matrix member formed from microporous ceramic. A chemical or biological material is fixed wit... | 07/29/1986 |
| 4601739 | Process for fractional distillation Existing fractional distillation columns, especially those in extensive commercial use for separating the lower molecular weight hydrocarbons, are often limited in the quality of separation achievable by the heat-absorbing capacity of and/or the minimum o... | 07/22/1986 |
| 4600468 | Machine for efficient assembly of biased yarn arrays This invention provides a machine for efficiently laying out biased arrays of yarns. The machine combines on a single supporting machine frame (1) two mechanically driven continuous yarn carrier strips, each provided on its edge facing the other carrier s... | 07/15/1986 |
| 4585056 | Heat exchanger The present invention relates to a heat exchanger which is specifically adapted for use in connection with blood oxygenators, particularly bubble oxygenators. The core of the heat exchanger is generally cylindrical and closed at both ends. The cylinder is... | 04/29/1986 |
| 4584227 | Joining tape Tape or patch material for making joints which have good tensile strength includes a reinforcing array of yarns arranged within a narrow range of angles around the direction of application of probable stress on the joint. The distribution of yarns angles ... | 04/22/1986 |
| 4581154 | Solvent composition for the removal of acid gas from gas mixtures at subfreezing temperatures A new solvent comprising a mixture of dialkyl ethers of polyalkylene glycols of the formula: CH3 O (C2 H4 O) x CH3 wherein x is 3 to 8 and having a molecular weight of 200 to 255 is disclosed. This solvent syste... | 04/08/1986 |
| 4501818 | Process for the preparation of ceramic powders Sub-micron sized powders of the ceramic metal oxides such as zirconia, alumina, titania, etc. are produced by precipitation from substantially anhydrous solutions of salts of the corresponding metal(s) with substantially anhydrous solutions of alkali meta... | 02/26/1985 |
| 4483932 | Refractory bodies for corrosive environments The gasification of coal can be accomplished more efficiently if it is operated at a temperature high enough so that the mineral constituents of the coal will form a molten slag which can be continuously removed from the gasifier during operation. Proper ... | 11/20/1984 |
| 4474585 | Synthetic yarn-reinforced flexible webs stabilized against elongation, coated abrasive thereon, and process therefor Conventional heat stretching and/or setting conditions for fabrics made of heat sensitive thermoplastic yarns such as polyester, and even special techniques advanced in prior patents, have been found in adequate to produce coated abrasives with sufficient... | 10/02/1984 |
| 4396657 | Fray and stretch resistant coated abrasive substrates impregnated with epoxy resins cured by specific types of catalysts Yarn arrays bonded with selected adhesives give coated abrasive products with reduced elongation under stress. Best results are obtained using epoxy resins with dicyandiamide, blocked isocyanates and/or imidazole curing agents as saturants for the yarn ar... | 08/02/1983 |
| 4396403 | Loading resistant coated abrasive Loading resistant coated abrasives can be made without the need for a supersize coating of metal stearates or any other material by incorporating phosphoric acids, partial esters of such acids, amine salts of such acids and partial esters, and/or quartern... | 08/02/1983 |
| 4269736 | Parafin conversion catalyst Drying of noble metal loaded mordenite in a humid atmosphere form a hydrated complex of the noble metal results in better catalytic activity of the ultimate calcined and reduced catalyst.... | 05/26/1981 |
| 4265323 | Direct bit drive for deep drilling tools The present invention relates to a direct bit drive for deep drilling tools based on the Moineau principles. The drive is divided into two sections disposed end-to-end and co-axially in line, each with a defined helical working space between surfaces shap... | 05/05/1981 |
| 4229457 | 3-(3-Substituted aryloxy)-2-yridinecarbonitriles, pharmaceutical compositions and methods for their production New 3-(3-methoxyphenoxy)-2-pyridinecarbonitriles, which are useful as pharmacological agents, especially as agents for the treatment of senility and reversal of amnesia, are disclosed. Other known 3-(3-substituted phenoxy)-2-pyridinecarbonitriles are disc... | 10/21/1980 |
| 4212980 | 5-Phenoxy-2-pyridinecarbonitrile compounds and methods for their production 5-phenoxy-2-pyridinecarbonitrile compounds, which are useful as pharmacological agents, especially as agents for the reversal of amnesia, and methods for their preparation are disclosed. Pharmaceutical compositions containing said compounds and methods fo... | 07/15/1980 |
| 4210758 | 1 ,5-Dihydro-1,5-dioxo-N-1H-tetrazol-5-yl-4H-[1]benzopyrano[3,4-b]pyridine- 2-carboxamides The present invention relates to 1,5-dihydro-1,5-dioxo-N-1H-tetrazol-5-yl-4H-[1]benzopyrano[3,4-b]pyridine- 2-carboxamides having the following structural formula: ##STR1## wherein R1 is hydrogen, halogen, hydroxy, lower alkoxy, lower alkyl... | 07/01/1980 |
| 4207320 | Amino-substituted imidazo[1,2-a:3,4-a']diquinolin-15-ium salts compositions and method of use Amino-substituted imidazo[1,2-a:3,4-a']diquinolin-15-ium salts having the formula I: ##STR1## wherein R1 is hydrogen, lower alkyl, C4 -C6 cycloalkyl, di(lower alkyl)amino, 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, ... | 06/10/1980 |
| 4198511 | 1,5-Dihydro-1,5-dioxo-N- 1H-tetrazol-5-yl-4H-[1]benzopyrano[3,4-b]pyridine-3-carboxamides and process thereof The present invention relates to 1,5-dihydro-1,5-dioxo-N-1H-tetrazol-5-yl-4H-[1]benzopyrano[3,4-b]pyridine- 3-carboxamides having the following structural formula: ##STR1## wherein R1 is hydrogen, halogen, hydroxy, lower alkoxy, lower alkyl... | 04/15/1980 |
| 4195176 | Imidazole compounds, methods for their production and conversion of said compounds into (R)-3-(2-deoxy-ଲ-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidaz ol[4,5-d][1,3]diazepin-8-ol 2-Amino-1-(5-amino-1H-imidazol-4-yl)ethanone, 6,7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one and acid-addition salts thereof are disclosed. 2-Amino-1-(5-amino-1H-imidazol-4-yl)ethanone and its acid-addition salts are prepared by catalytically reducing a... | 03/25/1980 |
| 4187311 | 3-Aryloxy-1-carboalkoxyethylpyridinium compounds and compositions 3-Aryloxy-1-carboalkoxyethylpyridinium compounds, which are useful as pharmacological agents, especially as agents for the treatment of senility and reversal of amnesia, are disclosed. The compounds can be produced by reacting 3-aryloxypyridine with an al... | 02/05/1980 |
| 4184253 | Denture and method of producing and fitting A prosthetic preform comprised of a hard base into which are molded the posterior prosthetic teeth, with the anterior prosthetic teeth being mounted in a waxy material contained in a cavity or cavities disposed in the hard base. The preform is further pro... | 01/22/1980 |
