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| Number | Title | Issue Date |
| 8175360 | Method and system of multivariate analysis on normalized volume-wise data in the sinogram domain for improved quality in positron emission tomography studies A method and system are provided for improving the quality in positron emission tomography (PET) images. PET input data is masked using raw dynamic PET data (sinograms) as input for primary component analysis (PCA) that generates primary components which in turn are... | 05/08/2012 |
| 8167864 | Spike-accommodating container holder A holding device for a container having a closure system to be pierced by a spike includes a base, a shield, and a mounting unit supporting the base. The base includes an elongate body having opposed first and second ends and an elongate body extending therebetween.... | 05/01/2012 |
| 8044377 | Shielded container The present invention provides a radiation-shielding container for a radiopharmaceutical that may be magnetically picked and placed, assembled and dis-assembled. ... | 10/25/2011 |
| 8035376 | Optical pumping modules, polarized gas blending and dispensing systems, and automated polarized gas distribution systems and related devices and methods A method of providing polarized noble gas for NMR or MRI applications incorporates a control module, a plurality of optical pumping modules each including an optical pumping cell operably associated with the control module; a plurality of dispensing systems, one for... | 10/11/2011 |
| 8033981 | Radioactive member and method of making A radioactive member for use in brachytherapy comprising a molded elongate, bioabsorbable carrier material with spaced radioactive sources disposed therein, and methods for the manufacture thereof. The radioactive members may be used in the treatment of, for example... | 10/11/2011 |
| 8007427 | Products and methods for brachytherapy A radioactive member for use in brachytherapy comprising a hollow elongate bioabsorbable suture member with radioactive seeds and spacer members without different coloration and diameter from the radioactive seeds alternately disposed therein, and methods for the ma... | 08/30/2011 |
| 8003077 | Method for the production of hyperpolarized Xe The present invention relates to a method for the production of hyperpolarized 129Xe and to a method for the production of a contrast agent. ... | 08/23/2011 |
| 7988612 | Carrier-free Pd brachytherapy seeds A brachytherapy seed comprising (a) carrier-free 103Pd isotope, (b) a substrate for the carrier-free 103Pd radioisotope, and (c) a casing for encapsulating the carrier-free 103Pd-laden substrate, is disclosed. ... | 08/02/2011 |
| 7931595 | Ultrasound triggering method to reduce cardiac arrhythmia The invention relates to a triggered ultrasound imaging method for imaging of the myocardium, minimizing the risk of eliciting cardiac arrhythmia. Particularly, the invention is directed to a method of assessing cardiac perfusion. Destruction pulses are triggered su... | 04/26/2011 |
| 7923690 | Method of and software for conducting motion correction in tomographic scanning and system for tomographic scanning using the method During data acquisition in a tomographic scan of a subject unscattered events and scatter events are collected. The data are corrected for the scatter events and movement of the subject during the scan. A scatter estimate is derived for use in the reconstruction of ... | 04/12/2011 |
| 7922707 | Devices and method for the penetration of a container stopper A spike for penetrating the elastomeric stopper of a container, for example a drug or reagent vial, is provided with an elongated body (5) with a blunt tip (47). The spike may be incorporated into a reagent cassette which accepts containers sealed with... | 04/12/2011 |
| 7902511 | Method of and software for calculating a scatter estimate for tomographic scanning and system for tomographic scanning The method calculates a scatter estimate for scatter correction of detection data from a subject in a positron emission tomographic scanner. The detection data represent the scattered events and unscattered events of annihilation photons emitted in the subject. The ... | 03/08/2011 |
| 7867477 | Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane o... | 01/11/2011 |
| 7850152 | Methods and devices for moisturizing hyperpolarized noble gases and associated moisturized pharmaceutical grade inhalable hyperpolarized gas products Methods and devices for moisturizing hyperpolarized noble gas and associated hyperpolarized noble gas products which are formulated for inhalation or ventilation delivery include adding moisture content to (dry) hyperpolarized gas. ... | 12/14/2010 |
| 7756307 | Method of, and software for, conducting motion correction for a tomographic scanner A method of conducting motion correction for a tomographic scanner including a detector array for detecting radiation to generate detector data. The method comprises storing detector data collected during a data acquisition period, the detector data being indicative... | 07/13/2010 |
| 7746075 | Methods, systems, circuits and computer program products for determining polarization of a gas A circuit for determining a polarization of a gas. The circuit includes a polarimetry circuit having an NMR coil that is configured to excite a polarized gas and that is responsive to an electromagnetic signal generated by the excited, polarized gas. The polarimetry... | 06/29/2010 |
| 7714291 | Method of and software for calculating a scatter estimate for tomographic scanning and system for tomographic scanning The method calculates a scatter estimate for annihilation photons in a subject having a distribution of attenuation. The method can be used for scatter correction of detection data from a positron emission tomographic scanner. The method uses the following steps: â€... | 05/11/2010 |
| 7592605 | Radioisotope generator and method of construction thereof A device for producing a fluid containing a radioactive constituent, comprising a shielded chamber (5) with an opening for receiving an isotope container (6) housing a radioactive isotope (7); a chamber closure (18) adapted for cooperatin... | 09/22/2009 |
| 7564035 | Generating detector efficiency estimates for a pet scanner Detector efficiency data is generated for a positron emission tomography scanner (2) including a single photon source by conducting a blank scan acquisition procedure using the single photon source. The acquired detection count data is processed using an effi... | 07/21/2009 |
| 7560096 | Diagnostic procedures using direct injection of gaseous hyperpolarized Xe and associated systems and products A method of screening for pulmonary embolism uses gaseous phase polarized 129Xe which is injected directly into the vasculature of a subject. The gaseous 129Xe can be delivered in a controlled manner such that the gas substantially dissolves in... | 07/14/2009 |
| 7557573 | NMR-based methods for detecting ligands, where the ligand or target are hyperpolarized and the NMR-spectrum is compared with a reference spectrum of the ligand or target The invention relates to NMR-based methods comprising hyperpolarised ligands or targets for use in NMR-based assays. ... | 07/07/2009 |
| 7550970 | Multidimensional NMR spectroscopy of a hyperpolarized sample The present invention relates to methods of performing Nuclear Magnetic Resonance (NMR) spectroscopy adapted for a hyperpolarized sample. The methods comprise the steps of hyperpolarizing a sample using DNP, wherein at least a portion of the NMR active nuclei receiv... | 06/23/2009 |
| 7547274 | Radioactive member and method of making A radioactive member for use in brachytherapy comprising a molded elongate, bioabsorbable carrier material with spaced radioactive sources disposed therein, and methods for the manufacture thereof. The radioactive members may be used in the treatment of, for example... | 06/16/2009 |
| D590953 | Laboratory glassware cassette | 04/21/2009 |
| 7501236 | NMR spectroscopic in vitro assay using hyperpolarization An in vitro assay method which comprises the use of an assay reagent containing at least one NMR active nucleus, and hyperpolarising at least one NMR active nucleus of the assay reagent; and analysing the assay reagent and/or the assay by NMR spectroscopy and/or NMR... | 03/10/2009 |
| 7459144 | Process for preparation of MR contrast agents The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogen... | 12/02/2008 |
| 7373782 | Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products Methods of collecting, thawing, and extending the useful polarized life of frozen polarized gases include heating a portion of the flow path and/or directly liquefying the frozen gas during thawing. A polarized noble gas product with an extended polarized life produ... | 05/20/2008 |
| 7372274 | Methods and devices configured for dissolving hyperpolarised solid material with a solvent within a cryostat for NMR analyses The present invention relates to devices and method for dissolving solid polarised material while retaining a high level of polarisation. In an embodiment of the present invention a material is polarised in a strong magnetic field in a cryostat 2 and then bro... | 05/13/2008 |
| 7357917 | Diagnostic procedures using Xe spectroscopy characterstic chemical shift to detect pathology in vivo An in vivo non-invasive method for detecting and/or diagnosing a pathological condition using hyperpolarized 129Xe spectroscopy is disclosed. Generally stated, the method includes determining the magnitude of spectral peaks which represent particular chem... | 04/15/2008 |
| 7346384 | Method of magnetic resonance investigation of a sample using a nuclear spin polarised MR imaging agent The present invention provides a method of contrast enhanced magnetic resonance imaging of a sample, said method comprising: a) administering a hyperpolarised MR contrast agent comprising non-zero nuclear spin nuclei into said sample for fluid dynamic investigations... | 03/18/2008 |
| 7322928 | Products and methods for brachytherapy A radioactive member for use in brachytherapy comprising a hollow elongate bioabsorbable suture member with radioactive seeds and spacer members without different coloration and diameter from the radioactive seeds alternately disposed therein, and methods for the ma... | 01/29/2008 |
| 7320322 | Valve for conducting hyperpolarized gas The valve of the present invention provides a one-piece valve stem piston having a piston head and a piston stem. The piston head has a larger diameter than the piston stem. The stem incorporates only a single sliding O-ring in the area that seals the gas in the val... | 01/22/2008 |
| 7287390 | Optical pumping modules, polarized gas blending and dispensing systems, and automated polarized gas distribution systems and related devices and methods Hyperpolarizers for producing polarized noble gases can include: (a) a control module configured to direct the operation of a hyperpolarizer to produce polarized noble gas via spin-exchange interactions between a noble gas and an alkali metal; (b) at least one optic... | 10/30/2007 |
| 7287391 | Automated modular hyperpolarizers and related devices and methods Modular expandable hyperpolarizers include a central control module and at least one optical pumping module that can be expandable to a plurality of optical pumping modules that can be separately operated depending on the capacity demands at the production site (hos... | 10/30/2007 |
| 7277775 | Automated dynamic pressure-responsive dispensing systems, and associated methods and computer program products Methods, systems and computer program products for dispensing hyperpolarized gas include or operate a plurality of spaced apart individually operable valves positioned in fluid communication with and located along a gas flow path. The gas flow path that is intermedi... | 10/02/2007 |
| 7275540 | MRI/NMR-compatible, tidal volume control and measurement systems, methods, and devices for respiratory and hyperpolarized gas delivery Ventilator systems include: (a) a mass flow controller; (b) a gas delivery valve in communication with the mass flow controller and configured to selectively dispense a plurality of different gases to a subject; (c) a first gas source in fluid communication with the... | 10/02/2007 |
| 7275413 | Methods, systems, circuits, and computer program products for determining polarization of a gas A system for determining polarization of a gas comprises a container that contains the polarized gas. An oscillator circuit comprises an Nuclear Magnetic Resonance (NMR) coil that is positioned adjacent to the container. A pulse generator circuit is configured to ge... | 10/02/2007 |
| 7251519 | MR-method for the in vivo measurement of temperature or pH-value by means of a hyperpolarised contrast agent The present invention provides a method of MR investigation of a sample, said method comprising: (i) nuclear spin polarizing a high T1 MR imaging agent which contains in its molecular structure at least two hyperpolarisable nuclei within the same molecule, the frequ... | 07/31/2007 |
| 7179450 | Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane o... | 02/20/2007 |
| 7127934 | Methods, systems, circuits, and computer program products for determining polarization of a gas A system for determining polarization of a gas comprises a container that contains the polarized gas. An oscillator circuit comprises an NMR coil that is positioned adjacent to the container. A pulse generator circuit is configured to generate an electrical pulse th... | 10/31/2006 |
