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| Number | Title | Issue Date |
| 8158583 | Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia Pharmaceutical composition for parenteral administration comprising a meal related insulin peptide and an insulinotropic peptide. ... | 04/17/2012 |
| 8137929 | Basic protein purification tags from thermophilic bacteria The invention is related to a method for purification of recombinant proteins using highly basic proteins from thermophilic bacteria as purification tags for use in a cation-exchange chromatography purification step. The basic proteins may be ribosomal proteins. The... | 03/20/2012 |
| 8088900 | Two-phase precipitation of proteins Provided are new methods for precipitating proteins comprising (a) providing a protein solution, (b) adding a salt to the solution, (c) either (i) adjusting pH of the composition to below the pI of the protein (in cases where the method is directed towards precipita... | 01/03/2012 |
| 8088731 | Use of GLP-1 compound for treatment of critically ill patients Use of medicament for life saving treatment of critically ill patients and method of treatment. The medicament comprises a GLP-1 compound which effectively controls the blood glucose level. ... | 01/03/2012 |
| 8076292 | Factor VIII: remodeling and glycoconjugation of factor VIII The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide. ... | 12/13/2011 |
| 8067362 | Insulin derivatives The present invention relates to insulin derivatives having a side chain attached either to the -amino group of the N-terminal amino acid residue of the B chain or to the amino group of a Lys residue present in the B chain of the parent insulin via an amide bond whi... | 11/29/2011 |
| 8008252 | Factor VII: remodeling and glycoconjugation of Factor VII The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide. ... | 08/30/2011 |
| 7932055 | Soluble heterodimeric CD94/NKG2 receptors fusion proteins Soluble versions of heterodimeric receptors, e.g., CD94/NKG2 receptors, and methods of producing and using such constructs, are described. The constructs comprise soluble fragments of, each receptor monomer, and some constructs further comprise at least one immunogl... | 04/26/2011 |
| 7879985 | Antibodies against human NKG2D and uses thereof The present invention provides isolated anti-human NKG2D monoclonal antibodies useful for therapeutic applications in humans. Typically, the antibodies are fully human or humanized to minimize the risk for immune responses against the antibodies when administered to... | 02/01/2011 |
| 7858747 | Expression of proteins in Plasmid comprising a DNA tag encoding a peptide tag of the sequence MX1(X2X3)n wherein X1 represents K, R or H; X2 represents A, G, H, M, S or T; X3 represents K, R, H, A, Q or V; n represe... | 12/28/2010 |
| 7858338 | Processing enzymes fused to basic protein tags The invention is related to processing enzyme comprising an N-terminally attached tag derived from highly basic proteins from thermophilic bacteria. The processing enzymes are useful for modifying proteins. They can be produced in high yields and can be effectively ... | 12/28/2010 |
| 7829529 | Use of factor VIIa or a tissue factor antagonist for regulating gene expression and cell migration or chemotaxis The present invention relates to use of FVII and/or FVIIa and/or another TF agonist and/or FVIIai and/or another TF antagonist in therapeutic treatment of pathological conditions that can be related to cell migration or treated by specific regulation of cell migrati... | 11/09/2010 |
| 7498024 | Compositions and methods for enhanced expression of immunoglobulins from a single vector using a peptide cleavage site Single vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The vectors comprise a self-processing cleavage sequence between a first and second immunoglobulin coding sequence allow... | 03/03/2009 |
| 7485291 | Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof Single vector constructs for expression of a functional antibody molecule are described. The vectors have a self-processing cleavage site between two heterologous DNA coding sequences allowing for expression of two coding sequences using a single promoter. Exemplary... | 02/03/2009 |
| 7482156 | Hepatocellular carcinoma specific promoter and uses thereof Liver cancer, particularly hepatocellular carcinoma specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, vi... | 01/27/2009 |
