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| Number | Title | Issue Date |
| 8143415 | Processes for making epothilone compounds and analogs A process for making epi-epothilone compounds according to formula A.1, by reacting a compound according formula C with at least one halogenating agent followed by treatment with ... | 03/27/2012 |
| RE42930 | Aziridinyl-epothilone compounds The present invention is directed to aziridinyl epothilone compounds as further described herein, and/or pharmaceutically-acceptable salts and/or solvates thereof having the following Formula: where... | 11/15/2011 |
| 7872145 | Aziridinyl-epothilone compounds The present invention is directed to aziridinyl epothilone compounds as further described herein, and/or pharmaceutically-acceptable salts and/or solvates thereof having the following Formula: where... | 01/18/2011 |
| 7378407 | Geldanamycin compounds and method of use Geldanamycin compounds having a structure according to formula I where Q1, L, L1, R5, R6, and R11 are as defined herein, are useful for treating a disease or disorder a... | 05/27/2008 |
| 7348436 | Compounds useful for the synthesis of (+)-discodermolide and methods thereof Compounds and methods useful for the synthesis of (+)-discodermolide, a naturally occurring microtubule stabilizing agent useful as an anti-cancer agent. ... | 03/25/2008 |
| 7259156 | Geldanamycin compounds and method of use Geldanamycin compounds having a structure according to formula I where Q1, L, L1, R5, R6, and R11 are as defined herein, are useful for treating a disease or... | 08/21/2007 |
| 7247617 | Sixteen-member macrolide antiinfective agents Sixteen membered macrolide anti-infective agents having a structure according to formula I where R1, R2, R3, R4, R5, and R6 are as defined herein,... | 07/24/2007 |
| 7241754 | 2-Desmethyl ansamycin compounds 2-Desmethyl ansamycins having a structure according to formula I, where R1, R2, R3, R4, R5 and R6 are as defined herein, and other 2-desmethyl ansamycins are useful as antiproliferative agents ... | 07/10/2007 |
| 7214708 | Synthetic discodermolide analogs Synthetic discodermolide analogs having utility as antiproliferative agents, having a structure represented by formula A where RA through RE and XA are as defined herein. ... | 05/08/2007 |
| 7211568 | 9-Desoxoerythromycin compounds as prokinetic agents 9-Desoxoerythromycin compounds of formula I wherein R1, R2, R3, R4, and R5 are as defined herein, are useful as prokinetic agents for treating disorders of g... | 05/01/2007 |
| 7091193 | Therapeutic formulations Formulations comprising one or more epothilones together with a pharmaceutically acceptable carrier, in particular such pharmaceutical compositions suitable for oral administration of an epothilone. ... | 08/15/2006 |
| 7067290 | Method for production of polyketides A method for the production of a polyketide by fermentation comprising the steps of growing a culture of a polyketide-producing organism at a pH value conducive to cell growth for a time sufficient to generate the producing culture, lowering the pH of the culture to... | 06/27/2006 |
| 6946482 | Motilide compounds Motilide compounds having the formula (I), wherein R1, R2, R3, and R4 are as defined herein, and methods for their preparation and use in the treatment of diseases or conditi... | 09/20/2005 |
| 6887993 | 11-O-methylgeldanamycin compounds Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents. ... | 05/03/2005 |
| 6875863 | 11-O-methylgeldanamycin compounds Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents. ... | 04/05/2005 |
| 6870049 | 11-O-methylgeldanamycin compounds Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents. ... | 03/22/2005 |
| 6855705 | 11-O-methylgeldanamycin compounds Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents. ... | 02/15/2005 |
| 6828126 | Methods for introducing hydroxyl or epoxide groups into polyketides using OleP The heterologous expression of the oleandomycin polyketide synthase (OlePKS) in Streptomyces lividans, produces 8,8 a-deoxyoleandolide, an aglycone precursor of oleandomycin. The co-expression with deoxyerythronolide B synthase (DEBS) in S. lividans of... | 12/07/2004 |
| 6794366 | Macrolide antiinfective agents Compounds of the formula or the 10,11-anhydro forms therefor, wherein Ra is H or OH; Rb is H or halogen; Rc is H or a protecting group; Rd is... | 09/21/2004 |
| 6762168 | Macrolide antiinfective agents The invention is directed towards antibacterial compounds. The invention concerns macrolide antibiotics useful as antiinfective agents. ... | 07/13/2004 |
| 6750205 | Motilide compounds The present invention provides novel macrolide compounds of the formulas wherein: R is hydroxyl or methoxy; R1 is selected from the group consisting of hydrogen, hydroxyl, halide, NH2,... | 06/15/2004 |
| 4838653 | Liquid crystal display with particular relationship of the capacitances A display comprises an array of a plurality of liquid crystal elements electrically connected in series. The element with the lowest capacitance when energized comprises a liquid crystal material having a positive dielectric anisotropy so that it has a hi... | 06/13/1989 |
| 4665151 | Preparing poly (arylene ketone) with liquefaction agent treatment The preparation of poly(arylene ketones) and in particular all para-linked poly(arylene ether ketones) by Friedel-Crafts polymerization in the presence of a Lewis acid generally results in an intractible reaction product difficult to remove from the react... | 05/12/1987 |
| 4644066 | Flame retardants and compositions containing them Flame retardants having good stability at the processing temperatures of high melting polymers are described. The flame retardants are halogen-containing bis-imides, for example, those of the formula ##STR1## R being defined in the specification.... | 02/17/1987 |
