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| Number | Title | Issue Date |
| 6605629 | Neurotrophin production secretion promoting agent A neurotrophin production/secretion promoting agent which comprises an azole derivative of the formula: ##STR1## wherein R1 represents a halogen atom, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionall... | 08/12/2003 |
| 6589547 | Sustained-release preparation for AII antagonist, production and use thereof The present invention is to provide a sustained-release preparation which comprises a compound having angiotensin II antagonistic activity, its pro-drug or their salt, and a biodegradable polymer, and if necessary, a polyvalent metal, and which is highly ... | 07/08/2003 |
| 6586004 | Solid preparation A solid preparation which comprises (i) a pharmaceutically active ingredient, (ii) one or more water-soluble sugar alcohol selected from the group consisting of sorbitol, maltitol, reduced starch saccharide, xylitol, reduced palatinose and erythritol, and... | 07/01/2003 |
| 6583164 | Antimycotic drug composition The composition of the present invention comprises a quaternized nitrogen-containing imidazole-1-yl or 1,2,4-triazole-1-yl compound wherein one of the nitrogen atoms constituting the azole ring is quaternized with a group eliminating in vivo and represent... | 06/24/2003 |
| 6573289 | Naphthalene derivatives, their production and use A composition containing a compound of the formula: ##STR1## wherein A is a nitrogen-containing heterocyclic group which may be substituted, R1 is a hydrogen atom, hydrocarbon group which may be substituted, or monocyclic aromatic heterocyclic ... | 06/03/2003 |
| 6566535 | Processes for the preparation of 2,3-dihydrothiepine derivatives A process for preparing a compound represented by the following formula: ##STR1## wherein each symbol is as defined below, or a salt thereof, characterized by subjecting a compound represented by the following formula: ##STR2## wherein R1 is an... | 05/20/2003 |
| 6555565 | Apoptosis inhibitor An apoptosis inhibitor which comprises a compound of the formula: ##STR1## wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: --CO--, --CH(OH)-- or --NR | 04/29/2003 |
| 6552054 | Chromone derivatives, process for the preparation of the same and uses thereof The invention provides chromone derivatives of the following general formula, a process for preparing such chromone derivatives and a prophylactic and therapeutic agent comprising such chromone derivatives for bone diseases and chondropathy: ##STR1##... | 04/22/2003 |
| 6534496 | Thermogenic composition and benzazepine thermogenics The object of the present invention is to provide a prophylactic and/or therapeutic drug for obesity and obesity-associated diseasestor diabetes with a reduced risk for central side effects and high universality in usage. Another object of the present inv... | 03/18/2003 |
| 6531604 | Benzothiepine derivatives, their production and use The invention provides compounds of the formula: ##STR1## wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen ... | 03/11/2003 |
| 6518257 | 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof To provide a composition having a steroid C17,20 -lyase inhibitory activity and useful as an agent for the prophylaxis or treatment of prostatism and tumors such as breast cancer. A compound represented by the formula: ##STR1## wherein R i... | 02/11/2003 |
| 6500820 | Pharmaceutical composition for neurotrophic action The present invention provides a composition for neurotrophic action which comprises a compound of the formula: ##STR1## wherein Ar is an optionally condensed phenyl group which may be substituted; n is an integer of 1 to 10; R is a hydrogen atom or a hydrocar... | 12/31/2002 |
| 6498019 | Lecithin-cholesterol acyltransferase protein This invention relates to a novel protein having a lecithin-cholesterol acyltransferase-like activity, etc. or its salt, a precursor protein of the protein or its salt, a partial peptide of the protein or its salt; a DNA coding for the protein; a recombin... | 12/24/2002 |
| 6495604 | Cycloalkene derivatives, process for producing the same, and use The present invention provides a compound represented by the formula: ##STR1## wherein R represents an aliphatic hydrocarbon group optionally having substituents, an aromatic hydrocarbon group optionally having substituents, a heterocyclic group optionall... | 12/17/2002 |
| 6495581 | Oxyiminoalkanoic acid derivatives A compound represented by the formula: ##STR1## wherein R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a bond, --CO--, --CH(OH)-- or a group represented by --NR6 -- wherein R | 12/17/2002 |
| 6482864 | Sustained-release preparation of physiologically active polypeptide and production thereof A method for producing a sustained-release preparation, which comprises dispersing a physiologically active polypeptide into an organic solvent solution of a biodegradable polymer and removing the organic solvent, wherein the polypeptide is a powder obtai... | 11/19/2002 |
| 6462058 | Benzimidazole compound crystal A novel crystal of (R)-2-[[[3-methyl-4-(2, 2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole or a salt thereof of the present invention is useful for an excellent antiulcer agent.... | 10/08/2002 |
| 6440946 | Multiple-agents-binding compound, production and use thereof The present invention is to provide a multiple-agents-binding compound comprising a compound having anti-HIV activity and having no affinity for cell surface protein bound together with a same or different kind of at least one compound having anti-HIV act... | 08/27/2002 |
| 6437132 | Thienopyridine derivatives, their intermediates and production thereof The present invention provides an intermediate for producing a thienopyridine derivative useful as a GnRH antagonist as well as an efficient and safe method for producing the same in an industrial scale at a high yield.... | 08/20/2002 |
| 6436966 | Adenosine A3 receptor antagonists A pharmaceutical composition for antagonizing adenosine at adenosine A3 receptors which comprises a 1,3-azole compound substituted on the 4- or 5-position, or both, by a pyridyl which may be substituted is provided and can be used as a prophyla... | 08/20/2002 |
| 6428813 | Gastrointestinal mucosa-adherent pharmaceutical composition In order to provide a composition having a long gastroduodenal residence time and exhibiting an improved efficacy, is provided a gastrointestinal mucosa-adherent composition comprising an active ingredient and a material which swells a viscogenic agent ca... | 08/06/2002 |
| 6423869 | Polyol-amino acid compounds having anti-helicobacter pylori activity A compound of the formula (I): ##STR1## wherein R1 represents an amino group which may be substituted; R2 represents a carboxy group which may be esterified or amidated; R3, R4, R5 and R6 e... | 07/23/2002 |
| 6420415 | Thiol compounds, their production and use Compounds represented by general formula (1) or salts thereof which have a matrix metalloprotease inhibitory activity and are useful as drugs, wherein the rings A and B represent each an optionally substituted homocycle or heterocycle, etc.; R1... | 07/16/2002 |
| 6420375 | Fused ring compounds, process for producing the same and use thereof To provide a novel compound of the formula: ##STR1## [wherein A1 ix a 5 or 6-membered ring which may be substituted by a group not containing a cyclic group, A2 is an aromatic ring which may be substituted, X is a divalent group, Y i... | 07/16/2002 |
| 6417213 | Tricyclic compound, their production and use A compound of the formula ##STR1## wherein R1 is H or a substituent; m is 1-3; Ar is an aromatic group which may be substituted; X is a bond or a divalent straight-chain group having 1-6 atoms which may be substituted; Y is --S--, --O--, or ... | 07/09/2002 |
| 6417175 | Phosphonocephem derivatives, process for the preparation of the same, and use thereof A novel cephem compound of the formula: ##STR1## wherein R1 is a phosphono group or a group convertible to a phosphono group; R2 is a hydrogen atom or a group having a linkage through a carbon atom; each of Q and X is a nitrogen atom... | 07/09/2002 |
| 6407129 | Azole compounds, their production and their use A quaternized nitrogen-containing imidazol-1-yl or 1,2,4-triazol-1-yl compound wherein one of the nitrogen atoms constituting an azole ring is quaternized with a substituent capable of being eliminated in vivo and the substituent can be eliminated in vivo... | 06/18/2002 |
| 6407116 | Nitrogenous fused-ring compounds, process for the preparation of the same, and drugs A compound represented by the formula: ##STR1## [wherein ring A represents a homocycle optionally having substituents or a nitrogen-containing heterocycle optionally having substituents; D and E are O or S; one of R1 and R2 represent... | 06/18/2002 |
| 6403595 | Sulfonamide derivatives, processes for producing the same and utilization thereof The present invention is to provide a compound or a salt thereof represented by the formula: ##STR1## wherein R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, the ring A is an optionally su... | 06/11/2002 |
| 6399639 | Apoptosis inhibitor An apoptosis inhibitor which comprises a compound of the formula: ##STR1## wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: --CO--, --CH(OH)-- or --NR | 06/04/2002 |
| 6399103 | Method of producing a sustained-release preparation A method of producing sustained-release microcapsules which comprises dispersing a physiologically active polypeptide into a solution of a biodegradable polymer and zinc oxide in an organic solvent, followed by removing the organic solvent; which provides... | 06/04/2002 |
| 6388022 | Linker binding carriers for organic synthesis, their production and use The present invention provides a linker binding carrier for organic synthesis represented by the formula: A--Z--W--(SO2 X)m wherein A is a carrier, X is a leaving group, Y is a bond or spacer, Z is a bivalent group, when Z is a bivalent electron att... | 05/14/2002 |
| 6387687 | Process for producing indolmycin A microorganism having indolmycin-producing ability and tryptophan analogue resistance is provided, and indolmycin or its salt can be produced efficiently by cultivating such microorganism in a medium to produce and accumulate indolmycin or its salt in th... | 05/14/2002 |
| 6359134 | Sulfonamide derivatives, their production and use The present invention provides compounds which specifically inhibit FXa, which are effective when orally administered and which are useful as a safe medicine for the prevention or treatment of diseases caused by thrombus or infarction. Compounds of this i... | 03/19/2002 |
| 6355672 | Benzothiepin derivatives, process for the preparation of the same and uses thereof The invention provides compounds of the formula: ##STR1## wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen ... | 03/12/2002 |
| 6350749 | Aminoguanidine hydrazone derivatives, process for producing the same and drugs thereof The present invention is to provide a compound of the formula: ##STR1## wherein the ring A is an optionally substituted 5- to 6-membered aromatic heterocyclic ring, the ring B an optionally substituted 5- to 6-membered aromatic homocyclic ring or an optio... | 02/26/2002 |
| 6348485 | Method for treating or preventing sleep disorders The present invention provides a pharmaceutical composition for treating or preventing sleep disorders which comprises (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]propionamide in combination with at least one active component selected fr... | 02/19/2002 |
| 6344209 | Apatite-coated solid composition An apatite-coated solid composition which contains a biodegradable polymer and an apatite-coated solid composition which contains a biodegradable polymer and a medicinal substance have properties of sustained release and of osteoconductive activity.... | 02/05/2002 |
| 6340704 | Cell differentiation inducing amide derivatives, their production and use The present invention provides a compound represented by the formula: ##STR1## wherein R1 is an amino group which may be substituted; R2 is a hydrogen atom or a lower alkyl group which may be substituted; X is a methyne group which m... | 01/22/2002 |
| 6340686 | Thienopyrimidine compounds, their production and use A compound of the formula: ##STR1## wherein R1 and R2 each is hydrogen, hydroxy, C1-4 alkoxy, C1-4 alkoxy-carbonyl or C1-4 alkyl which may be substituted; R3 is hydrogen, halogen, hydroxy o... | 01/22/2002 |
