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| Number | Title | Issue Date |
| 8183017 | Method of producing L-lysine The ability and speed with which a coryneform bacterium can produce L-lysine are improved when the coryneform bacterium contains an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized. This is accomplished by successi... | 05/22/2012 |
| 8178322 | Method for producing an L-amino acid or a nucleic acid A method is described for producing an L-amino acid or a nucleic acid by culturing a microorganism having an ability to produce the L-amino acid or nucleic acid in a liquid medium in a fermentation tank containing a stirring impeller, and optionally adding seed crys... | 05/15/2012 |
| 8173605 | Kokumi-imparting agent The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink... | 05/08/2012 |
| 8137938 | Method for producing an L-amino acid An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which is able to produce the L-amino acid, and is modified so that the activity of ribonuclease G is decreased in a medium containing glycerol as the carbon source, and ... | 03/20/2012 |
| 8114651 | Method for producing 4-hydroxy-L-isoleucine A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and iso... | 02/14/2012 |
| 8114649 | L-cysteine producing microorganism and a method for producing L-cysteine L-cysteine is produced by culturing an Escherichia bacterium having L-cysteine producing ability and containing a gene encoding an O-acetylserine sulphydrylase B or MalY regulatory protein that is modified so that cysteine desulfhydrase activity is reduced or... | 02/14/2012 |
| 8114639 | Method for producing an L-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the sfmACDFH-fimZ cluster or the fimZ gene The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the sfmACDF... | 02/14/2012 |
| 8110381 | L-glutamic acid-producing bacterium and method for production of L-glutamic acid A method for producing L-glutamic acid by culturing a coryneform bacterium in which the gluX is inactivated in a medium to produce L-glutamic acid in the medium or cells, and collecting L-glutamic acid from the medium. ... | 02/07/2012 |
| 8106020 | Calcium receptor activator A calcium receptor activator and compositions containing at least one of the following: γ-Glu-Cys-Gly, γ-Glu-Cys(SNO)-Gly, γ-Glu-Ala, γ-Glu-Gly, γ-Glu-Cys, γ-Glu-Met, γ-Glu-Thr, γ-Glu-Val, γ-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, D-C... | 01/31/2012 |
| 8105802 | Method of producing microbial transglutaminase The present invention provides a neutral metalloprotease from actinomycetes which selectively cleaves a pro-structure part of a microbial protransglutaminase and a gene encoding said neutral metalloprotease. An active microbial transglutaminase having the pro-struct... | 01/31/2012 |
| 8093346 | Method for producing an aminohydroxybenzoic acid-type compound Provided is a method for efficiently producing a 3-amino-4-hydroxybenzoic acid-type compound by culturing a coryneform bacterium that has a gene encoding a mutated aspartokinase not subject to feedback inhibition, and that is transformed with a recombinant vector co... | 01/10/2012 |
| 8088606 | Method for producing an L-amino acid using bacterium of the family with attenuated expression of a gene coding for small RNA The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of a gene codi... | 01/03/2012 |
| 8084032 | Purification method which prevents denaturation of an antibody The present invention provides a method of purifying an antibody by protein A affinity chromatography. More specifically, the present invention provides a technique relating to an elution buffer solution which provides a good antibody recovery rate without denaturat... | 12/27/2011 |
| 8080396 | Microorganism producing an amino acid of the L-glutamic acid family and a method for producing the amino acid A microorganism is cultured in a medium, and is able to produce one or two or more kinds of L-amino acids including L-glutamic acid, L-glutamine, L-proline, L-ornithine, L-citrulline and L-arginine, and is modified to increase α-ketoglutarate synthase activity. The... | 12/20/2011 |
| 8076111 | Method for producing an organic acid An organic acid is produced by allowing a bacterium which has an ability to produce an organic acid and has been modified so that expression of yidE gene is enhanced, or a product obtained by processing the bacterium, to act on an organic raw material in a reaction ... | 12/13/2011 |
| 8071339 | Mutant phosphoribosylpyrophosphate synthetase and method for producing L-histidine The present invention relates to a mutant bacterial PRPP synthetase which is resistant to feedback by purine nucleotides, and a method for producing L-histidine using the bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacter... | 12/06/2011 |
| 8062869 | Method for producing L-lysine An Escherichia bacterium having dihydrodipicolinate synthase and aspartokinase, both of which are desensitized to feedback inhibition by L-lysine. The intracellular activity of dihydrodipicolinate reductase in this bacterium can also be enhanced. Furthermore,... | 11/22/2011 |
| 8058035 | Method for producing an L-amino acid A microorganism which has an L-amino acid producing ability and has been modified so that succinate dehydrogenase activity and α-ketoglutarate dehydrogenase activity are decreased is cultured in a medium to produce and accumulate an L-amino acid in the medium or ce... | 11/15/2011 |
| 8034767 | Method for producing purine nucleosides and nucleotides by fermentation using a bacterium belonging to the genus or A method is provided for producing a purine nucleoside, such as inosine and guanosine, and a method for producing a 5′-purine nucleotide such as 5′-inosinic acid or 5′-guanylic acid, using a bacterium belonging to the either genus Escherichia or genus | 10/11/2011 |
| 8030036 | Method for producing L-lysine or L-threonine A bacterium belonging to the genus Escherichia which has an ability to produce L-lysine or L-threonine and which is modified so that a malic enzyme does not function normally in a cell, and a method for producing L-lysine or L-threonine, comprising culturing ... | 10/04/2011 |
| 8017363 | Method for production of L-lysine using methanol-utilizing bacterium A method for production of L-lysine is provided which includes the steps of cultivating a methanol-utilizing bacterium in a culture medium to produce and accumulate L-lysine in the culture medium and collecting the L-lysine from the culture medium, wherein the metha... | 09/13/2011 |
| 8012722 | Method for producing L-amino acid L-amino acids such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, and L-cysteine are produced by culturing in a medium a bacterium having an L-amino acid-producing ability and wherein the bacterium has been modified so that the phosphotransacetyl... | 09/06/2011 |
| 8008048 | L-cysteine-producing bacterium and a method for producing L-cysteine The present invention provides a bacterium belonging to the family Enterobacteriaceae which has L-cysteine-producing ability and has been modified to decrease the activity of the protein encoded by the yhaM gene. This bacterium is cultured in a medium, and L-cystein... | 08/30/2011 |
| 8008047 | L-amino acid producing bacterium which has enhanced expression of at least one of the nhaA gene, the nhaB gene, the nhaR gene, the chaA gene, the mdfA gene and a method of producing L-amino acid L-amino acid is produced by culturing a bacterium belonging to the Enterobacteriaceae family which has L-amino acid-producing ability and is modified so that expression of the nhaA gene, nhaB gene, nhaR gene, chaA gene, mdfA gene, or combinations thereof is enhanced... | 08/30/2011 |
| 8003367 | Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes A method for producing an L-amino acid, such as L-histidine, L-threonine, L-lysine, L-glutamic acid, and L-tryptophan, using bacterium belonging to the genus Escherichia which has increased expression of genes, such as those of the xylABFGHR locus, which enco... | 08/23/2011 |
| 7993885 | Method for producing L-lysine or L-arginine by using methanol assimilating bacterium A DNA encoding a variant of a protein having a loop region and six hydrophobic helixes which is involved in excretion of L-lysine to outside of a cell is described, wherein the DNA encodes a mutant protein which does not contain the loop region that is present in th... | 08/09/2011 |
| 7981645 | Enzymatic asymmetric decarboxylation of disubstituted malonic acids A process for the stereoselective decarboxylation of malonic acid derivatives with mutated decarboxylases is disclosed. ... | 07/19/2011 |
| 7964709 | Mutant tyrosine repressor, a gene encoding the same, and a method for producing L-DOPA A mutant tyrosine repressor that does not require tyrosine to induce expression of tyrosine phenol-lyase gene is obtained by introducing a mutation into a tyrosine repressor. A microorganism which is able to express large amounts of tyrosine phenol-lyase is obtained... | 06/21/2011 |
| 7943364 | Method for producing L-glutamine and L-glutamine producing bacterium L-glutamine is produced by culturing a coryneform bacterium having L-glutamine-producing ability and modified so that intracellular glutaminase activity is reduced, and preferably also modified so that intracellular glutamine synthetase activity is enhanced. The met... | 05/17/2011 |
| 7927844 | L-glutamic acid-producing microorganism and a method for producing L-glutamic acid A coryneform bacterium that is modified by using a yggB gene so that L-glutamic acid-producing ability is enhanced as compared to a non-modified strains is cultured in a medium to cause accumulation of L-glutamic acid in the medium or bacterial cells, and L-glutamic... | 04/19/2011 |
| 7919314 | Process for the production of monoclonal antibodies Provided is a use of a recombinant chimaeric protein as an immunogen in a process for producing a monoclonal antibody, wherein the recombinant chimaeric protein is assembled into a virus-like particles, and includes a foreign protein or peptide or a fragment thereof... | 04/05/2011 |
| 7919284 | L-amino acid producing microorganism and a method for producing an L-amino acid A microorganism belonging to the family Enterobacteriaceae, which has an L-amino acid-producing ability and has been modified so that the kdp system is enhanced, is cultured in a medium to produce and accumulate an L-amino acid in the medium or cells of the microorg... | 04/05/2011 |
| 7919283 | Method for producing an L-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of any of the cynT, cynS, cynX or cynR gene or combination thereof The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of one or more... | 04/05/2011 |
| 7919282 | Method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family with attenuated expression of the gene The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the cpxR ge... | 04/05/2011 |
| 7915018 | Method for producing L-amino acids using bacteria of the Enterobacteriaceae family There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity... | 03/29/2011 |
| 7892833 | Using inhibitors of histone deacetylases for the suppression therapy of inherited disease predisposing conditions Compounds can be used to act as inhibitors of enzymes having histone deacetylase activity for the medical therapy of conditions which predispose a person for the development of a disease, such as but not limited to cancer, inflammatory or metabolic diseases. Such co... | 02/22/2011 |
| 7888077 | Method for producing an L-amino acid using a bacterium of the family with attenuated expression of the gene The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the kef... | 02/15/2011 |
| 7846698 | Method of producing L-lysine The L-lysine-producing ability and the L-lysine-producing speed are improved in a coryneform bacterium harboring an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized, by successively enhancing DNA coding for a dihyd... | 12/07/2010 |
| 7879863 | Aniline derivatives The present invention provides a novel compound having a kininogenase-inhibitory action and its pharmaceutical use. The compounds are represented by the formulas (A), (B), (C), (E) and (H): wherein each symbol is as defined... | 02/01/2011 |
| 7879583 | Process for producing L-glutamic acid L-glutamic acid is produced by culturing a microorganism in a liquid medium containing L-glutamic acid at a saturation concentration, wherein the microorganism can metabolize a carbon source at a specific pH, and also has an ability to accumulate L-glutamic acid in ... | 02/01/2011 |
