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Attorney: Caruso; Charles M.


Number of patents: 19
Last date: September 07, 1993

NumberTitleIssue Date
5242076Child resistant medication container assemblage
There is disclosed a child resistant medication container assemblage comprising a container base having a plurality of medication compartments formed therein to house unit doses of medication. The container base is provided with means to receive a slidabl...
09/07/1993
5237061Methods of synthesizing benign prostatic hypertropic agents and their intermediates
A process for preparing compounds of the formula ##STR1## which comprises reacting an imidazolide of the formula ##STR2## with an amine of the formula NHR4 R5 in the presence of a Grignard reagent to form a compound of form...
08/17/1993
5227303Sample dissolution chamber
There is disclosed an automated system for testing the sterility of products intended for human health administration or for human consumption. The system permits a plurality of samples of a product to be concurrently tested. To accomplish this, the syste...
07/13/1993
485968117 ଱-Acyl-4-aza-5a-androst-1-en-3-ones as 5 alpha-reductase inhibitors
17ଲ-Acyl-4-aza-5଱-androst-1-en-3-ones of the formula: ##STR1## wherein R is selected from hydrogen, methyl and ethyl and R2 is a monovalent radical selected from straight carbons, or monocyclic aryl optionally containing 1 or more l...
08/22/1989
48534152-(substituted sulfamyl) derivatives of 4-nitrobenzamide as radiation sensitizers
2-(Substituted sulfamyl) derivatives of 4-nitrobenzamide are disclosed as agents that increase the sensitivity of hypoxic cancer cells to x-rays and γ-radiation. Methods of preparing such compounds, protocols for administering them to human patients and ...
08/01/1989
4835313(5,6-dichloro-3-oxo-9଱-propyl-2,3,9,9଱-tet rahydrofluoren-7-yl) alkanimidamides
The invention relates to novel [5,6-dichloro-3-oxo-9a-propyl-2,3,9,9a -tetrahydrofluoren-7-yl)]alkanoic acids and alkanimidamides, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of e...
05/30/1989
4814324Sterol inhibitors of testosterone 5଱-reductase
The compounds of Formula I are produced by the aerobic fermentation of a fungus of the genus GLIOCLADIUM, ATCC No. 20826. ##STR1## The compounds of Formula I are inhibitors of testosterone 5଱-reductase and are useful in the treatment and preven...
03/21/1989
4808608Tetrahydrocarbazole 1-alkanoic acids, pharmaceutical compositions and use
Tetrahydrocarbazole 1-alkanoic acids are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platlet aggregation, cerebral spasm, premature labor, spontaneous abortio...
02/28/1989
4803217Hapalindolinone compounds as vassopressin antagonists
Hapalindolinone compounds are produced by the controlled aerobic fermentation of a cyanobacterium of the genus Fischerella, ATCC No. 53558. These compounds are antagonists of vasopressin and are useful in the treatment and prevention of disease states whe...
02/07/1989
4797391((5,6-dichloro-3-oxo-9,9a-d isubstituted-2,3,9,9a-tetrahydrofluoren-7-yl)oxy)alkanoic acids and alkanimidamides
The invention relates to novel [(5,6-dichloro-3-oxo-9,9a-disubstituted-2,3,9,9a-tetrahydro-fluoren-7-yl)o xy]alkanoic acids and alkanimidamides, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the ...
01/10/1989
47788976H-dibenz[b,e][1,4]oxathiepin compounds
Novel 6H-dibenz[b,e][1,4]oxathiepin derivatives of the formulae I and Ia are employed in the treatment and control of allergic conditions such as allergic asthma. ##STR1##...
10/18/1988
4689160Acid stable heteropolysaccharide s-421
Heteropolysaccharide S-421, prepared by fermentation of an unidentified Agrobacterium species ATCC 53378, has valuable properties as an acid stable heteropolysaccharide and is especially valuable for use in acidizing fluids....
08/25/1987
4605664Use of substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-dione s for treatment of grey matter edema
The invention relates to novel substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, their analogs and their salts. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular ...
08/12/1986
4605760Preparation of an enantiomer of a substituted fluorenyloxyacetic acid
A process for direct preparation of an enantiomer of a substituted fluorenyloxyacetic acid is disclosed. The acetic acid derivative is useful for treating brain edema....
08/12/1986
4605761Process using achiral co-catalyst promoter for chiral phase transfer alkylation process for an enantiomer of a substituted fluorenyloxyacetic acid
An improved method for the direct preparation of an enantiomer of a substituted fluorenyloxyacetic acid including the enhancement of a chiral phase transfer alkylation step in the synthesis using a non-ionic surfactant as co-catalyst. The substituted fluo...
08/12/1986
4605663Use of substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-dione s, for treatment of grey matter edema
The invention relates to novel substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, their analogs and their salts. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular ...
08/12/1986
4604403Use of substituted-3(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones for treating grey matter edema
The invention relates to novel substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, their analogs and their salts. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular ...
08/05/1986
4604396[(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimida mides and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimid ic acid hydrazides, their derivatives and their salts
The invention relates to novel [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-yl)oxy]ethanimidamid es and [(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]ethanimidic acid hydrazides, their derivatives and their salts. The compoun...
08/05/1986
4596821Treatment of gray matter edema with 3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones
The invention relates to novel substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, their analogs and their salts. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular ...
06/24/1986
 
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