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| Number | Title | Issue Date |
| 6587792 | Nuclear packing efficiency Methods and devices for determining the nuclear packing efficiency (NPE) of a cell nucleus and other biological particles. An NPE can be determined by correlating at least one biochemical component, such as DNA content, to nuclear volume using a variety o... | 07/01/2003 |
| 6586579 | PR-domain containing nucleic acids, polypeptides, antibodies and methods The invention provides an isolated PR Family Member (PFM) nucleic acid molecule that contains a PFM PR domain nucleotide sequence, a PFM ZF domain nucleotide sequence, or a modification thereof. The invention also provides an isolated PFM nucleic acid mol... | 07/01/2003 |
| 6576239 | Angiogenic homing molecules and conjugates derived therefrom The present invention provides tumor homing molecules, which selectively home to a tumor. The invention also provides methods of using a tumor homing molecule to target an agent such as a drug to a selected tumor or to identify the target molecule express... | 06/10/2003 |
| 6566497 | Nucleic acid encoding a family of acetyl-coenzyme-a transporter proteins, and products related thereto In accordance with the present invention, there are provided isolated mammalian Acetyl-Coenzyme A Transporter (AT) proteins, anti-AT antibodies, therapeutic compositions, and nucleic acids encoding such. Bioassays and therapeutic methods employing inventi... | 05/20/2003 |
| 6557296 | Non-infectious, protease defective HIV particles and nucleic acid molecules encoding therefor This invention is directed toward mutated DNA, proteins, or protein fragments and particles from the L-2 cell line. The invention is also directed to diagnostic, prophylactic and therapeutic methods of making and using the DNA, proteins and particles.... | 05/06/2003 |
| 6551990 | Methods of inhibiting ectopic calcification The invention provides a method of inhibiting ectopic calcification in an individual. The method consists of administering to the individual a therapeutically effective amount of osteopontin or a functional fragment thereof.... | 04/22/2003 |
| 6551575 | Methods for identifying compounds for motion sickness, vertigo and other disorders related to balance and the perception of gravity The present invention provides a method of identifying a compound that modulates a mammalian vestibular system. The method consists of administering a test compound to an invertebrate, and measuring a geotactic behavior of the invertebrate, where a compou... | 04/22/2003 |
| 6551588 | Tumor radiosensitization using gene therapy The invention provides a method of radiosensitizing a tumor in a subject by contacting the tumor with a cytokine or a nucleic acid molecule encoding a cytokine. The invention also provides a method of radiosensitizing a tumor in a subject by administering... | 04/22/2003 |
| 6545128 | Anti-bax inhibitor protein antibodies The present invention provides substantially purified nucleic acid molecules encoding Bax inhibitor protein-1 (BI-1; SEQ ID NO: 1) or Bax inhibitor protein-2 (BI-2; SEQ ID NO: 4), nucleic acid molecules complementary thereto (SEQ ID NO: 2 and SEQ ID NO: 5... | 04/08/2003 |
| 6544955 | Method of sensitizing tumor cells with adenovirus E1A The present invention is directed to methods of sensitizing a human tumor cell with adenovirus E1A. The methods involve treating a human tumor cell by, first, introducing into the tumor cell nucleic acid encoding a polypeptide having adenovirus E1A activi... | 04/08/2003 |
| 6537806 | Compositions and methods for treating diabetes The present invention provides an isolated population of cells containing an expressible nucleic acid encoding proinsulin containing a proinsulin cleavage site and a glucose-regulated expressible nucleic acid encoding a protease capable of cleaving the pr... | 03/25/2003 |
| 6537768 | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC panca antigens The present invention relates to microbial UC pANCA antigens. The invention provides methods of diagnosing ulcerative colitis (UC) and methods of inducing tolerance in a pANCA-positive patient with UC using a histone H1-like antigen. The invention further... | 03/25/2003 |
| 6534503 | Melanocortin receptor-3 ligands to treat sexual dysfunction Methods for treating sexual dysfunction, such as erectile dysfunction or sexual arousal disorder, with a compound having the generic formula X1 --X2 -(D)Phe-Arg-(D)Trp-X3. A particularly useful compound is HP-228, which ha... | 03/18/2003 |
| 6534263 | Methods of screening for Crohn's disease using TNF microsatellite alleles A novel association between certain tumor necrosis factor microsatellite alleles and Crohn's disease has been discovered. In accordance with the present invention, there is provided methods for screening for Crohn's disease comprising detecting the presen... | 03/18/2003 |
| 6531580 | Anti-v댣 recombinant human antibodies and nucleic acids encoding same The invention provides enhanced LM609 grafted antibodies exhibiting selective binding affinity to Vଲ.sub.3, or a functional fragment thereof. The invention also provides nucleic acid molecules encoding the enhanced LM609 grafted an... | 03/11/2003 |
| 6528481 | NG2/HM proteoglycan-binding peptides that home to angiogenic vasculature and related methods The present invention provides angiogenic vasculature homing molecules that bind to NG2/HM proteoglycan, including, for example, a peptide comprising the amino acid sequence TAASGVRSMH (SEQ ID NO:1) or LTLRWVGLMS (SEQ ID NO:2). The invention also provides... | 03/04/2003 |
| 6524797 | Methods of identifying therapeutic compounds in a genetically defined setting The invention provides a method of identifying therapeutic compounds in a genetically defined setting. The method consists of contacting a cell indicative of a pathological condition from a diseased individual and a cell from a genetically related normal ... | 02/25/2003 |
| 6524585 | Indolicidin analogs and methods of using same The present invention relates to analogs of indolicidin, which is a naturally occurring peptide having the amino acid sequence Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2 ("Indol 1-13;" SEQ ID NO: 1). The indolicidin analogs of the ... | 02/25/2003 |
| 6521594 | Method and composition for treating thrombosis The invention provides cyclic peptides which inhibit platelet aggregation without causing prolonged bleeding time. The invention provides RGD or KGD containing peptides which are cyclized and contain hydrophobic amino acids adjacent to the carboxy terminu... | 02/18/2003 |
| 6521427 | Method for the complete chemical synthesis and assembly of genes and genomes The present invention relates generally to the fields of oligonucleotide synthesis. More particularly, it concerns the assembly of genes and genomes of completely synthetic artificial organisms. Thus, the present invention outlines a novel approach to uti... | 02/18/2003 |
| 6515197 | Transgenic mouse expressing a polynucleotide encoding a human ataxin-2 polypeptide The invention provides a transgenic non-human mammal comprising nucleated cells containing a transgene encoding an ataxin-2 polypeptide comprising a polyglutamine tract. In particular, the transgenic-non-human mammal can be a mouse. The invention also pro... | 02/04/2003 |
| 6514761 | Methods of using BCL-2 for the therapeutic treatment and prevention of diseases The invention provides a method of treating a disease or pathological condition resulting in apoptotic cell death. The method includes increasing the activity of Bcl-2 in cells affected by the disease or pathological condition. Diseases or pathological co... | 02/04/2003 |
| 6514727 | Antimicrobial theta defensins and methods of using same The present invention relates to an isolated cyclic peptide, theta defensin, having antimicrobial activity, and to theta defensin analogs. A theta defensin can have the amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-X... | 02/04/2003 |
| 6509314 | Methods of preventing or reducing scarring with decorin or biglycan The present invention relates to methods of preventing or reducing scarring in a wound area by administering decorin or biglycan to the wound.... | 01/21/2003 |
| 6491894 | NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same The present invention provides a method of identifying a tumor homing molecule that homes to angiogenic vasculature by contacting a substantially purified NGR receptor with one or more molecules and determining specific binding of a molecule to the NGR re... | 12/10/2002 |
| 6492107 | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique The present invention is directed to a process for the production of a peptide, polypeptide, or protein having a predetermined property. In accordance with one embodiment, the process begins by producing by way of synthetic polynucleotide coupling, stocha... | 12/10/2002 |
| 6482407 | Membrane-bound cytokine compositions comprising GM-CSF or an active fragment thereof and methods of modulating and an immune response using the same The present invention provides a cellular vaccine having a membrane-bound fusion protein that includes a non-antibody immunomodulatory molecule operatively fused to a heterologous membrane attachment domain. Non-antibody immunomodulatory molecules useful ... | 11/19/2002 |
| 6475488 | Methods of inhibiting angiogenesis and ameliorating cancer by using superfibronectin The invention provides a method of inhibiting angiogenesis and treating pathologies with angioproliferative components. The invention provides a method of ameliorating tumor growth and metastasis in a subject comprising administering a superfibronectin or... | 11/05/2002 |
| 6468985 | Retinoblastoma protein-interacting zinc finger proteins The present invention provides mammalian retinoblastoma (Rb) protein-interacting zinc finger (RIZ) proteins, nucleic acid molecules encoding the RIZ and antibodies specific for the RIZ. The invention also provides screening assays for identifying an agent... | 10/22/2002 |
| 6464978 | Vaccination and methods against multiple sclerosis resulting from pathogenic responses by specific T cell populations The present invention provides vaccines and a means of vaccinating a mammal so as to prevent or control specific T cell mediated pathologies or to treat the unregulated replication of T cells. The vaccine is composed of a T cell receptor (TCR) or a fragme... | 10/15/2002 |
| 6458585 | Cytokine-free culture of dendritic cells A method for producing human dendritic cells for therapeutic purposes which allows culture-deriving dendritic cells using no cytokines, or reduced cytokines. The method involves culturing mononuclear cells from blood or bone marrow in a medium containing ... | 10/01/2002 |
| 6451969 | Methods for inhibiting tumor metastasis, and peptides useful therfor In accordance with the present invention, there are provided peptides that bind to a member of the mammalian selectin family and inhibit the binding of a carbohydrate to the selectin. Invention peptides are useful to inhibit of the adhesion of cells conta... | 09/17/2002 |
| 6447769 | Compositions and methods for enhanced tumor cell immunity in vivo The invention provides a method of preventing or reducing the severity of a cancer in a subject by stimulating the subject's immune response against the cancer. The invention provides, for example, a method of stimulating an immune response in a subject b... | 09/10/2002 |
| 6444645 | Crosslink-stabilized indolicidin analogs The present invention relates to crosslink-stabilized analogs of indolicidin, which is a naturally occurring peptide having the amino acid sequence Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-CONH2 ("Indol 1-13;" SEQ ID NO: 1). The cros... | 09/03/2002 |
| 6436900 | Methods of treating a pathology or a fibrotic condition by administering decorin The present invention provides methods of treating pathologies using Decorin.... | 08/20/2002 |
| 6419883 | Chemical synthesis using solvent microdroplets The present invention relates to microdroplets of a solution comprising a solvent having a boiling point of 150° C. or above, a surface tension of 30 dynes/cm or above, and a viscosity of 0.015 g/(cm)(sec). Such microdroplets are useful for the synthesis... | 07/16/2002 |
| 6420126 | Tumor specific internalizing antigens and methods for targeting therapeutic agents The invention provides a method of reducing the proliferation of a neoplastic cell. The method consists of contacting the neoplastic cell with a cytotoxic or cytostatic binding agent specifically reactive with an aberrantly expressed vesicular membrane as... | 07/16/2002 |
| 6413516 | Peptides and methods against psoriasis This invention relates to methods of preventing or reducing the severity of psoriasis. In one embodiment, the method involves administering to the individual a peptide having substantially the sequence of a non-conserved region sequence of a T cell recept... | 07/02/2002 |
| 6395524 | Thermostable polymerases having altered fidelity and method of identifying and using same The present invention provides a method for identifying a thermostable polymerase having altered fidelity. The method consists of generating a random population of polymerase mutants by mutating at least one amino acid residue of a thermostable polymerase... | 05/28/2002 |
| 6395873 | Method and composition for treating thrombosis The invention provides cyclic peptides which inhibit platelet aggregation without causing prolonged bleeding time. The invention provides RGD or KGD containing peptides which are cyclized and contain hydrophobic moieties adjacent to the carboxy terminus o... | 05/28/2002 |
