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Glam girl Heddy Lamar may have used her good looks to good effect on the silver screen, but she put her smarts to better use as an inventor. During World War II, she co-patented a frequency-switching system for torpedo guidance that was considered years ahead of its time.

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Attorney: CV Therapeutics, Inc.


Number of patents: 24
Last date: April 21, 2009

NumberTitleIssue Date
7521554Aadenosine receptor antagonists
Disclosed are processes for the synthesis of novel compounds that are A2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea. ...
04/21/2009
7517888Aadenosine receptor antagonists
Disclosed are A1 adenosine receptor antagonists having the general formula The compounds are useful for treating various disease states, in particular disease states for which diuretic treatment is appropriate....
04/14/2009
7514417A adenosine receptor agonists
Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists having the structure of Formula I: which are useful for treating various disease states, in particular tachycardia and atrial...
04/07/2009
7368434Compounds useful for the inhibition of ALDH
The present invention provides novel antidipsotropic compounds. The invention further provides methods of inhibiting ALDH-2 using the compounds described herein. Methods for modulating alcohol consumption, alcohol dependence and/or alcohol abuse by administering the...
05/06/2008
7317017Aadenosine receptor antagonists
Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract dis...
01/08/2008
7304070Aadenosine receptor antagonists
Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II: The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract di...
12/04/2007
7300923Partial and full agonists of A1 adenosine receptors
Disclosed are syntheses suitable for large scale manufacture of novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infa...
11/27/2007
7238700Aadenosine receptor antagonists
Disclosed are novel A2B adenosine receptor antagonists of Formula I: A compound of the formula: wherein: R1 is...
07/03/2007
7208496Substituted heterocyclic compounds
Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, inte...
04/24/2007
7160592Polymer coating for medical devices
Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a poly...
01/09/2007
7157440Partial and full agonists of A1 adenosine receptors
Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction. ...
01/02/2007
7125993Aadenosine receptor antagonists
Disclosed are processes for the synthesis of novel compounds that are A2B adenosine receptor antagonists, having the structure of Formula I or Formula II: by cyclizing a compound of the formula (3):
10/24/2006
7125876Substituted heterocyclic compounds
Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, inte...
10/24/2006
7115610Substituted heterocyclic compounds
Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atri...
10/03/2006
7109330Purine inhibitors of cyclin dependent kinase 2 and IκB-α
Compounds of the following formula are provided: In the Formula (I), R1 is —X—R1′; in which R1′ is optionally substituted lower alkyl, optionally substituted aryl, optiona...
09/19/2006
7071174Method and composition for inhibiting cholesterol esterase
This invention encompasses methods for manufacturing purified, high molecular weight sulfated polysaccharide compositions that inhibit pancreatic cholesterol esterase and lower cholesterol in the blood stream. ...
07/04/2006
6919339ABCA-1 elevating compounds
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery dis...
07/19/2005
6852723Aralkyl substituted piperazine compounds
Novel compounds of the general formula: and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to pr...
02/08/2005
6852724Sustained release ranolazine formulations
A sustained release ranolazine formulation contains an intimate mixture of ranolazine and a partially neutralized pH-dependent binder to form a film that is mostly insoluble in aqueous media below pH 4.5 and soluble in aqueous media above pH 4.5. The formulation is ...
02/08/2005
6849632Heteroaryl alkyl piperazine derivatives
Novel compounds of the general formula: and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to pr...
02/01/2005
6790958Purine inhibitors of cyclin dependent kinase 2 & IKBA
Compounds of the following formula are provided: wherein: R1 is —X—R1′; in which R1′ is alkyl, cycloalkyl, aryl, aralkyl, hetaryl, or heterocyclyl, all of which are optiona...
09/14/2004
6781000Alpha-ketoamide inhibitors of 20S proteasome
α-ketoamide compounds useful for treating disorders mediated by 20S proteasome in mammals having the following formula: wherein X2 is Ar or Ar—X3 wherein X3 is is —C═O, or —CH
08/24/2004
6713650ABCA-1 elevating compounds
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery dis...
03/30/2004
6599283Method of preventing reperfusion injury
Methods are disclosed for preventing or inhibiting reperfusion injury to the ischemic myocardium....
07/29/2003
 
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