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| Number | Title | Issue Date |
| 8185321 | Method for predicting interaction between protein and chemical The present invention provides a method for configuring a pattern recognizer using versatile, readily available data, comprehensive protein data, and comprehensive chemical data, as well as a method for predicting an unknown interaction of a pair by using the patter... | 05/22/2012 |
| 8178663 | Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring The present invention relates to hyaluronic acid ester derivatives, whose carboxylic groups are partially esterified with hydroxy groups of propiophenone derivatives, to the hydrogel materials consisting of the said hyaluronic acid ester derivatives, to their prepar... | 05/15/2012 |
| 8178620 | Surface modifying macromolecules with high degradation temperatures and uses thereof The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polyme... | 05/15/2012 |
| 8178499 | Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring The present invention relates to hyaluronic acid ester derivatives, whose carboxylic groups are partially esterified with hydroxy groups of propiophenone derivatives, to the hydrogel materials consisting of the said hyaluronic acid ester derivatives, to their prepar... | 05/15/2012 |
| 8178135 | Aqueous solution of conophylline and/or conophyllidine PROBLEMS TO BE SOLVED BY THE INVENTION To provide aqueous solutions of conophylline and/or conophyllidine; methods for purifying conophylline and/or conophyllidine from the aqueous solutions; methods for producing the aqueous solutions, water-soluble composit... | 05/15/2012 |
| 8178100 | Antibodies to IP-10 for treating bone diseases with bone destruction The present invention is directed to providing the IP-10 protein (interferon-γ-inducible protein 10) as a novel therapeutic target relating to the etiology of bone diseases with bone destruction associated with RNAKL expression and osteoclast formation. More specif... | 05/15/2012 |
| 8177565 | Electrical connection apparatus with movable parts The invention features an electrical connection apparatus capable of operatively attaching to an electrical appliance or electrical socket. The apparatus also includes at least two electrical connections which can communicate with each other to allow the flow of ele... | 05/15/2012 |
| 8173813 | Quinolone and tetrahydroquinolone and related compounds having NOS inhibitory activity The present invention features quinolones, tetrahydroquinolines, and related compounds that inhibit nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors... | 05/08/2012 |
| 8173129 | Methods and compositions for treating autoimmune diseases The invention features methods for increasing or maintaining the number of functional cells of a predetermined type, for example, insulin producing cells of the pancreas, blood cells, spleen cells, brain cells, heart cells, vascular tissue cells, cells of the bile d... | 05/08/2012 |
| 8172788 | Adhesion prevention and an intra-abdominal cooling and insufflation assembly therefor By present invention it has been found that hypothermia decreases adhesion formation more specifically pneumoperitoneum-enhanced adhesion formation. A cooling system has been designed to reduce the peritoneal cavity temperature during surgery, while maintaining at a... | 05/08/2012 |
| 8163696 | Treatment of inflammatory bowel disease using glucagon-like-peptide-2 (GLP-2) analogues GLP-2 analogues are disclosed which comprise one of more substitutions as compared to [hGly2]GLP-2 and which improved biological activity in vivo and/or improved chemical stability, e.g., as assessed in in vitro stability assays. More particularly, preferred GLP-2 a... | 04/24/2012 |
| 8163526 | Ethanol production A method for increasing production of ethanol in an ethanologenic cell using an autoinducer molecule, for example, AI-2. ... | 04/24/2012 |
| 8163511 | Methods for the identification of LRRK2 interacting molecules The invention features methods for the identification of leucine-rich kinase 2 (LRRK2) inhibitors using indol ligand 91. Generally, these methods include identifying compounds that compete with indol ligand 91 for binding to LRRK2. ... | 04/24/2012 |
| 8163475 | Methods for diagnosis and prognosis of psychotic disorders The invention features methods diagnostic of a psychotic disorder such as bipolar disorder or schizophrenia. The methods include obtaining a cell sample from a subject, subjecting a cell from the sample to stress (e.g., nutrient stress), and measuring nucleic acid o... | 04/24/2012 |
| 8158357 | Compositions and method for storage of nucleic acid from bodily fluids An aqueous composition comprising a denaturing agent, a chelator, a buffering agent and a protease for the extraction of nucleic acid from a sample of bodily fluid, such as saliva, such that the extracted nucleic acid is stable for at least fourteen days at room tem... | 04/17/2012 |
| 8153787 | Azacytosine derivatives useful as antiviral agents The present invention provides 5-azacytosine derivatives with antiviral activity, specifically having viral replication inhibiting properties, more particularly in DNA viruses such as pox-, papilloma- and herpes viruses in humans. The invention also provides pharmac... | 04/10/2012 |
| 8153389 | Methods for the identification of PI3K interacting molecules and for the purification of PI3K The present invention relates to methods for the identification of a PI3K interacting compound using phenylthiazole ligand 1. ... | 04/10/2012 |
| 8148554 | Methods and compositions for use in treating cancer The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer, and intermediates for the synthesis of such compositions. ... | 04/03/2012 |
| 8147860 | Porous calcium phosphate bone material Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected pores and a cohe... | 04/03/2012 |
| 8147850 | Immunogenic constructs The present invention relates to molecules, which can be used to induce a therapeutic or prophylactic immune response against MAP. In particular, the present invention relates to polypeptides comprising an alipC polypeptide sequence, a gsd polypeptide sequence, a p1... | 04/03/2012 |
| 8143374 | Polypeptide derivatives of parathyroid hormone (PTH) The present invention is related to novel parathyroid hormone polypeptide derivatives, and to pharmaceutical composition containing the polypeptides, as well as synthetic and recombinant methods for producing the polypeptides. Also disclosed are methods for treating... | 03/27/2012 |
| 8143300 | Inhibitors of cellular necrosis The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly u... | 03/27/2012 |
| 8142795 | Stabilizer and vaccine composition comprising one or more live attenuated flaviviruses The present invention relates to stabilizers for compositions, including immunogenic compositions, such as vaccine compositions, comprising one or more live attenuated flaviviruses, to bulk vaccine compositions stabilized with these stabilizers, particularly dry vac... | 03/27/2012 |
| 8142758 | Alpha-emitting hydroxyapatite particles The present invention provides Hydroxyapatite (HA) incorporating an alpha-emitting radionuclide or an in vivo generator for an alpha-emitting radionuclide. The invention further provides methods for the formation of such HA, pharmaceutical compositions comprising th... | 03/27/2012 |
| 8137926 | Kit for assaying EphA4 processing by gamma-secretase The present invention provides a kit for assaying the processing of EphA4 by γ-secretase. ... | 03/20/2012 |
| 8133998 | Bicyclic pyrimidine derivatives as calcium channel blockers Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing thienopyrimidine or oxoquinazoline deri... | 03/13/2012 |
| 8133490 | Method and system to remove cytokine inhibitors in patients A method to treat cancer uses ultrapheresis, refined to remove compounds of less than 120,000 daltons molecular weight, followed by administration of replacement fluid, to stimulate the patient's immune system to attack solid tumors. In the preferred embodiment, the... | 03/13/2012 |
| 8129131 | Pin1 as a marker for abnormal cell growth Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In one embodiment, the method includes detecting a level of Pin1 to stage an abnormal cell growth, such as breast or prostate cancer. In another embodiment, the method includes evaluating... | 03/06/2012 |
| 8124587 | 2-(aminomethyl)-5-chlorobenzylamide derivatives and their use as inhibitors of the clotting factor Xa 2-(Aminomethyl)-5-chlorobenzylamide derivatives and their use as inhibitors of coagulation factor Xa are provided. The compounds are suitable for the treatment and prophylaxis of cardiovascular and thrombotic events. ... | 02/28/2012 |
| 8124398 | Recombinant flavivirus vaccines The invention provides recombinant flavivirus vaccines that can be used in the prevention and treatment of flavivirus infection. The vaccines of the invention contain recombinant flaviviruses including attenuating mutations. ... | 02/28/2012 |
| 8123948 | Biomimetic water membrane comprising aquaporins used in the production of salinity power The present invention provides methods for producing salinity power using pressure retarded osmosis and a biometric membrane (e.g., a liquid bilayer membrane or a lipid membrane containing multiple bilayers of fused deposited lipid vesicles) containing aquaporin wat... | 02/28/2012 |
| 8123663 | Exercise apparatus and apparel The invention provides an exercise apparatus containing a compressible member, which provides physical instability and improves core muscle development in an exercising person. In addition, the invention provides an article of clothing containing a compressible memb... | 02/28/2012 |
| 8119785 | Nucleic acid sequences and homologous recombination vectors for distruption of a Fel D I gene A transgenic cat with a phenotype characterized by the substantial absence of the major cat allergen, Fel d I. The phenotype is conferred in the transgenic cat by disrupting the coding sequence of the target gene with a specialized construct. The phenotype of the tr... | 02/21/2012 |
| 8114892 | Methods and compositions for the treatment of Parkinson's Disease The invention features methods and kits for treating or inhibiting the development of Parkinson's Disease by administering 7-chloro-4-aminoquinoline compounds, e.g., amodiaquine or glafenine. Stem cells are also useful in the methods of the invention and may be admi... | 02/14/2012 |
| 8110676 | Prodrugs activated by RNA-dependent DNA-polymerases The invention provides prodrugs activated by RNA-dependent DNA-polymerases, and methods for treating hematological tumors, blood, and blood derivatives from patients affected by retroviral infections by administering the prodrugs. The invention also provides methods... | 02/07/2012 |
| 8110213 | Method of forming a tissue structure by introducing cells into an implanted matrix Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the ma... | 02/07/2012 |
| 8106164 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof The invention pertains to the development of antibodies that specifically bind amyloid beta protein (Abeta) in its protofibril conformation. The invention also comprises methods of using anti-Abeta protofibril antibodies to diagnose or treat Alzheimer's disease, Dow... | 01/31/2012 |
| 8106071 | Compositions for treating hyperproliferative vascular disorders and cancers The present invention relates to a method for treating or reducing the development of a hyperproliferative disorder, which comprises administering to a subject a composition, which comprises as an active ingredient the compound rep... | 01/31/2012 |
| 8106043 | Benzoxazines, benzothiazines, and related compounds having NOS inhibitory activity The present invention features benzothiazines that inhibit nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms, and that have the formula: ... | 01/31/2012 |
| 8105803 | Phosphatases involved in the regulation of cardiomyocyte differentiation An object of the invention is to provide a dephosphorylation enzyme that regulates cardiomyocyte differentiation, dominant negative enzyme thereof, a gene encoding the enzyme protein and use thereof. A protein or the like consisting of any one of the following amino... | 01/31/2012 |
