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| Number | Title | Issue Date |
| 7807165 | Antibodies directed against amyloid-beta peptide and methods using same Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described. Methods of using antibodies directed agains... | 10/05/2010 |
| 7771748 | Pharmaceutical compositions of 5,7,14-triazatetracyclo[10.3.1.0.0]-hexadeca-2(11),3,5,7,9-pentaene The present invention is directed to controlled-release (CR) oral pharmaceutical dosage forms of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene, 1, and pharmaceutically acceptable salts thereof, and methods of using ... | 08/10/2010 |
| 7700618 | Sulfonyl benzimidazole derivatives This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein A, R1, R2, R3, R4, R5, m and n are each as described herein, and compositions containing such compou... | 04/20/2010 |
| 7645407 | Method of sealing a hard shell capsule A method is disclosed for the sealing of hard shell capsules having coaxial body parts which overlap when telescopically joined. Also described is an apparatus to seal the capsules. The method comprises the steps of holding the capsule in a precise and upright posit... | 01/12/2010 |
| 7595329 | Benzimidazolone carboxylic acid derivatives This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions co... | 09/29/2009 |
| 7589109 | Oxyindole derivatives This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: A, R1, R2, R3, R4 and R5 are each as described... | 09/15/2009 |
| 7517909 | Amino acids with affinity for the α2δ-protein This invention relates to certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders. ... | 04/14/2009 |
| 7491835 | Prodrugs of amino acids with affinity for the α2δ-protein This invention relates to prodrugs of certain amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorde... | 02/17/2009 |
| 7473787 | Bicyclic [3.1.0] derivatives as glycine transporter inhibitors The present invention relates to a series of substituted bicyclic[3.1.0]amines of the Formula I: wherein A, B, D, Q, V, W, X, Y, Z, R2, R3, R4, R5, R14, R15, R... | 01/06/2009 |
| 7442694 | Diazabicyclic compounds useful in the treatment of CNS and other disorders The present invention relates to a compounds of formula I: wherein A, B, D, E and F are defined herein; that are useful in treating central nervous system (CNS) diseases, disorders and conditions, such as but not limited to... | 10/28/2008 |
| 7439236 | Pharmaceutical composition for the treatment of CNS and other disorders The present invention relates to compounds of formula I The substituent designations are as disclosed. At least one of B, Q, D and E is nitrogen. The present invention also provides a method of treating disorders of the Centr... | 10/21/2008 |
| 7345038 | Pyridyloxymethyl and benzisoxazole azabicyclic derivatives An aminomethylpyridyloxymethyl/benzisoxazole substituted azabicyclic compound of formula I, pharmaceutical composition comprising same, and a method of treating one or more CNS or other disorders, including concurrent treatment of disorders such as schizophrenia and... | 03/18/2008 |
| 7267718 | Pullulan film compositions The invention concerns compositions based on pullulan and a setting system for the use in pharmaceutical, veterinary, food, cosmetic or other products like films for wrapping food, aspics or jellies, preferably for predosed formulations like soft or hard capsules. T... | 09/11/2007 |
| 6974828 | Propanoic acid derivatives as intergrin receptor antagonists Novel propanoic acid derivatives are integrin receptor antagonists or inhibitors, in particular of the avb3 integrin receptor. The compounds of the invention are for instance useful for the treatment of solid tumors by inhibition of angiogenic growth of tumor vessel... | 12/13/2005 |
| 6972298 | Method of treating or inhibiting neutrophil chemotaxis by administering a MEK inhibitor The present invention provides a method of treating or preventing neutrophil chemotaxis. Specifically, the present invention provides a method of treating or preventing neutrophil migration by administering to a patient a MEK inhibitor. ... | 12/06/2005 |
| 6964961 | Thiophene derivatives useful as anticancer agents The invention relates to compounds of the formula 1 or a pharmaceutically acceptable salt and to pharmaceutically acceptable salts and hydrates thereof, wherein X, Y, R1, R2 and R11 are... | 11/15/2005 |
| 6949652 | Crystalline forms of 3-isopropyl-6-[4-(2,5-difluoro-phenyl)-oxazol-5-yl]-[1,2,4]triazolo-[4,3-A]pyridine The present invention relates to novel crystalline forms of 3-isopropyl-6-[4-(2,5-difluoro-phenyl)-oxazol-5-yl]-[1,2,4]triazolo-[4,3-a]pyridine to pharmaceutical compositions containing such crystal forms and to methods of treatment. 3-Isopropyl-6-[4-(2,5-difluoro-p... | 09/27/2005 |
| 6943183 | 5-substituted tetralones as inhibitors of ras farnesyl transferase The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, ... | 09/13/2005 |
| 6927219 | N-alkyl-adamantyl triazinyl benzamide derivatives The present invention relates to novel to N-alkyl adamantyl triazinyl benzylamide derivatives of formmula I: and to processs for their preparation, intermediates useful in their preparation, pharmaceutical compositions... | 08/09/2005 |
| 6927220 | Bicyclic-substituted 4-amino-pyridopyrimidine derivatives The invention relates to 6- or 7-bicyclic-substituted 4-amino-subsituted pyridopyrimidines and to pharmaceutically acceptable salts, prodrugs and hydrates thereof. The invention also relates to pharmaceutical compositions containing the compounds and to methods of t... | 08/09/2005 |
| 6916807 | Triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, G, and W are as ... | 07/12/2005 |
| 6916800 | Combination therapy including a matrix metalloproteinase inhibitor and an antineoplastic agent The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of a matrix metalloproteinase inhibitor and an antineoplastic agent. ... | 07/12/2005 |
| 6890924 | Substituted bicyclic derivatives for the treatment of abnormal cell growth The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R5, R11, m and p a... | 05/10/2005 |
| 6867201 | Heteroaromatic bicyclic derivatives useful as anticancer agents The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R1, R3 and R4 are as defined herein. The invention also ... | 03/15/2005 |
| 6844357 | Substituted quinolin-2-one derivatives useful as antiproliferative agents The present invention relates to compounds of formulas 1 and 2 wherein R1, R2, R4, R5, R6, R7, R8, R10 and Z are as defined herein... | 01/18/2005 |
| 6844349 | Salt forms of E-2-methoxy-N-(3-{4-[3 methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide and method of production The invention relates to succinate and malonate complexes of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide having the following formula I: More particular the p... | 01/18/2005 |
| 6831091 | Salt forms of 3-(4-bromo-2,6-difluoro-benzyloxy)-5-[3-(4-pyrrolidin-1-yl-butyl)-ureido]-isothiazole-4-carboxylic acid amide and method of production The invention relates to hydrochloride, hydrobromide, hemi-citrate, acetate, p-tosylate, L-tartrate, hemi-succinate, and mesylate salt forms of 3-(4-bromo-2,6-difluoro-benzyloxy)-5-[3-(4-pyrrolidin-1-yl-butyl)-ureido]-isothiazole-4-carboxylic acid amide having the f... | 12/14/2004 |
| 6784299 | Substituted aromatic ethers as inhibitors of glycine transport This invention relates to a series of substituted aromatic ethers of the formula I wherein ring A and X and Y are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutic... | 08/31/2004 |
| 6770778 | N-(4-substituted phenyl)-anthranilic acid hydroxamate esters The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions, and methods of use thereof. ... | 08/03/2004 |
| 6750217 | Benzenesulfonamide derivatives and their use as MEK inhibitors Benzenesulfonamides of formula (I), in which W is OR1, NR2OR1, NRARB, NR2NRARB, or NR2(CH2)2-4NR | 06/15/2004 |
| 6713496 | 3-(imidazolyl)-2-alkoxypropanoic acids Compounds according to formula (I) wherein n is 0-3, R1 is optionally substituted C1-8 alkyl, C2-6 alkenyl, or C2-6 alkynyl, Heterocycle, Aromatic heterocycle, Aryl or hydrogen and R2, R3, R4 | 03/30/2004 |
| 6696464 | Triazolo-pyridines anti-inflammatory compounds The present invention relates to novel triazolo-pyridines of the formula I ##STR1## wherein Het is an optionally substituted 5-membered heterocycle containing one to two heteroatoms selected from nitrogen, sulfur and oxygen wherein at least one of sai... | 02/24/2004 |
| 6664395 | Benzotriazoles anti-inflammatory compounds The present invention relates to novel benzotriazoles of the formula I ##STR1## wherein Het is an optionally substituted 5-membered heterocycle containing one to two heteroatoms selected from nitrogen, sulfur and oxygen wherein at least one of said hetero... | 12/16/2003 |
| 6620829 | Method of treating noninflammatory cartilage damage The invention relates to a method of treating non inflammatory cartilage damage by administering a GABA analog of Formula: ##STR1## and pharmaceutically acceptable salts thereof.... | 09/16/2003 |
| 5734053 | Purinone antianginal agents | 03/31/1998 |
