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| Number | Title | Issue Date |
| 8123065 | Container with lid A container with a lid comprises a container portion (10) having an opening portion (11) for the loading or unloading of a sample or the like, a lid portion (20) that can be detachably fitted in said opening portion (11) so as to close th... | 02/28/2012 |
| 8114348 | Label-free high throughput biomolecular screening system and method A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be... | 02/14/2012 |
| 8066961 | Kinematic wellplate mounting method A mechanism for positionally restraining a microplate is disclosed. The mechanism is defined by a base having at least one surface with a receptacle for the insertion of a microplate into the base. Supports and/or positioning structures on a surface of the base have... | 11/29/2011 |
| 8021613 | System and method for self-referencing a sensor in a micron-sized deep flow chamber A system and method are described herein for self-referencing a sensor that is used to detect a biomolecular binding event and/or kinetics which occur in a sample solution flowing along side a reference solution in a micron-sized deep flow channel. ... | 09/20/2011 |
| 7999944 | Multi-channel swept wavelength optical interrogation system and method for using same A multi-channel swept wavelength optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which for example could be located within the wells of a microplate. In one embodiment, the optical interrogation ... | 08/16/2011 |
| 7979241 | Optimized method for LID biosensor resonance detection An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation e... | 07/12/2011 |
| 7976217 | Screening system and method for analyzing a plurality of biosensors A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable... | 07/12/2011 |
| 7871811 | Method for eliminating crosstalk between waveguide grating-based biosensors located in a microplate and the resulting microplate The present invention includes several methods for modifying the current processes of manufacturing optical sensing microplates that use continuous waveguide films to reduce/eliminate crosstalk between the biosensors that are incorporated within wells. The methods i... | 01/18/2011 |
| 7851208 | Optical reader system and method for monitoring and correcting lateral and angular misaligments of label independent biosensors An optical reader system and method are described herein that can detect a lateral and/or angular misalignment of one or more biosensors so that the biosensors can be properly re-located after being removed from and then reinserted into the optical reader system. In... | 12/14/2010 |
| 7830513 | Optical interrogation system and microplate position correction method An optical interrogation system and method are described herein that are capable of detecting and correcting a positional misalignment of a label independent detection (LID) microplate so that the LID microplate can be properly interrogated after being removed from ... | 11/09/2010 |
| 7824624 | Closed flow-through microplate and methods for using and manufacturing same A closed flow-through microplate is described herein that can be used to perform high-throughput kinetic flow-through assays to detect biomolecular interactions like material bindings, adsorptions etc. . . that is helpful for example with testing new drugs. A method... | 11/02/2010 |
| 7776609 | Reference microplates and methods for making and using the reference microplates A reference microplate is described herein which can be used to help calibrate and troubleshoot an optical interrogation system. In one embodiment, the reference microplate has a frame with an array of wells each of which contains an optical biosensor and each optic... | 08/17/2010 |
| 7729573 | Single mode (SM) fiber optical reader system and method for interrogating resonant waveguide-grating sensor (S) An optical reader system is described herein which has a single mode (SM) optical fiber launch/receive system that uses one or more SM optical fibers to interrogate a biosensor and does not use multimode (MM) optical fibers to interrogate the biosensor. The use of t... | 06/01/2010 |
| 7396848 | Neurotrophin production/secretion promoting agent A neurotrophin production/secretion promoting agent which comprises an azole derivative of the formula: wherein R1 represents a halogen atom, a heterocyclic group which may optionally be substituted, a hydroxy gr... | 07/08/2008 |
| 7371721 | Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes The present invention relates to methods for prevention and treatment of bone-related disorders and calcium homeostasis related syndromes using a GLP-2 molecule or GLP-2 activator either alone or in combination with another therapeutic. The present invention also en... | 05/13/2008 |
| 7329739 | Use of lectin library for distinguishing glycoproteins or cells, diagnosing serum or cells, or fractionating glycoproteins or cells It is intended to provide lectins and a lectin library comprising these lectins which are useful in recognizing differences in carbohydrates on cell surface (for example, sugar chains and cell surface glycoproteins) reflecting extremely subtle differences among cell... | 02/12/2008 |
| 7294475 | Gene and use thereof A protein and DNA encoding the same are useful as preventives/remedies for diseases such as hypoglycemia, etc. The protein of the present invention is also useful as a reagent for screening a compound that inhibits the binding of the protein of the present invention... | 11/13/2007 |
| 7288266 | Liposome complexes for increased systemic delivery Highly efficient cationic liposomes have been developed as an improved delivery system for biologically-active reagents. A novel structure, the sandwich liposome, is formed and comprises one or more biologically active agents internalized between two bilomellar lipo... | 10/30/2007 |
| 6960444 | Transcriptional mediators of blood vessel development and endothelial differentiation This invention relates to methods of modulating the development of blood vessels and/or endothelial cell differentiation in a mammal comprising altering the activity of an Ets transcription factor, which activates vascular specific genes. More particularly, the tran... | 11/01/2005 |
| 6943151 | Method of inhibiting bone resorption and/or promoting bone formation using GLP-2 and related compounds Disclosed are methods of inhibiting bone resorption and/or promoting bone formation using GLP-2 and related Compounds. The invention has a wide spectrum of important uses including hyperparathyroidism, Paget's disease, hypercalcemia of malignancy, osteolytic lesions... | 09/13/2005 |
| 5494079 | Stop-gate apparatus and methods of use thereof The present invention relates to a stop-gate apparatus which is used as a means of opening and enclosing a hollow container or conduit carrier. The apparatus is comprised of a coupling body and an enclosure plate. The coupling body is affixed at one end t... | 02/27/1996 |
| 5447387 | Traction providing device(s) for open grid bridges and methods of use The invention pertains to a device which, when inserted and affixed to an open grid deck spaces of an open grid bridge, provides increased traction for trespassing motor vehicles. The invention also pertains to methods of affixing the traction providing d... | 09/05/1995 |
| 5438130 | Fucosylated guanosine disulfates as excitatory amino acid antagonists A compound consisting of a base, a ribose and a fucose, in which the base is a purine or a pyrimidine, the ribose has R1 and R2 attached respectively to any two of 2'-O, 3'-O and 5'-O, and the fucose has R3, R4 ... | 08/01/1995 |
