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| Number | Title | Issue Date |
| 7655471 | Biochemical markers of the human endometrium Endometrium secreted polypeptides are assayed in body fluids to determine the presence of polypeptides of specified pI and MW values that have been found to be regulated in body fluids according to the status of the endometrium, or the presence of hyperplasia or ade... | 02/02/2010 |
| 7632684 | Assay of isomerised and/or optically inverted proteins and protein fragments In an in vitro diagnostic test for osteoarthritis or rheumatoid arthritis, the amount or presence in a sample of anisomerised or optically inverted protein fragment is measured which derives from perlecan, bigylcan, decorin, fibrillin-1 or protocadherin or which is ... | 12/15/2009 |
| 7625869 | Metastin derivatives and use thereof The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, met... | 12/01/2009 |
| 7501286 | Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry The invention provides reagents, kits and methods for detecting and/or quantifying proteins in complex mixtures, such as a cell lysate. The methods can be used in high throughput assays to profile cellular proteomes. In one aspect, the invention provides a peptide i... | 03/10/2009 |
| 7482329 | Single domain TDF-related compounds and analogs thereof The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators ... | 01/27/2009 |
| 7463758 | Method of deriving a quantitative measure of a degree of calcification of an aorta A method of deriving a quantitative measure of a degree of calcification of a blood vessel such as an aorta by processing an image such as an X-ray image of at least a part of the blood vessel containing said calcification comprises: taking a starting set of digital... | 12/09/2008 |
| 7427686 | (3R, 4R)-trans-3, 4-diarylchroman derivatives and a method for the prevention and/or treatment of estrogen dependent diseases The present invention relates to compounds of the formula I in which substituents R2 and R3 are arranged in trans-configuration: wherein: R1 is H or C1-C6 ... | 09/23/2008 |
| 7419973 | Phosphonocephem compound A cephem compound (particularly its crystal) represented by the formula [I], wherein X is CH3COOH, CH3CH2COOH or CH3CN, and n is 0 to 5, is useful as an antibacterial agent (particularly anti-MRSA agent) and shows superior... | 09/02/2008 |
| 7250272 | G protein-coupled receptor protein and DNA thereof The present invention aims at providing a useful and novel G protein-coupled receptor protein and DNA thereof. The G protein-coupled receptor protein of the present invention and the like, and the polynucleotides encoding the receptor protein and the like, ar... | 07/31/2007 |
| 7235267 | Brain cell or nerve cell-protecting agents comprising medicinal ginseng The present invention provides medicinal or pharmaceutical compositions and preparations for administration, which are useful as cytoprotective agents and a remedy for neurotrauma, comprising ginseng, its extract, ginseng components, metabolites thereof or salts the... | 06/26/2007 |
| 7217808 | RFRP-3 and DNA thereof The RFRP-3 peptide of the present invention which is an agent for promoting prolactin secretion is useful as a prophylactic and/or therapeutic agent for various diseases associated with prolactin secretion, such as hypoovarianism, seminal vesicle hypoplasia, menopau... | 05/15/2007 |
| 7193053 | Hypoxia-inducible factor 1alpha variants and methods of use This invention relates to unique variant forms of HIF-1 alpha polypeptide that are stable under hypoxic and nonhypoxic conditions and their use in the treatment of disorders involving oxygen homeostasis. ... | 03/20/2007 |
| 7186683 | Use of GLP for the treatment, prevention, diagnosis, and prognosis of bone-related and nutrition-related disorders The present invention relates to methods for prevention and treatment of bone-related or nutrition-related disorders using a GLP molecule or GLP activator either alone or in combination with another therapeutic. The present invention also encompasses methods of diag... | 03/06/2007 |
| 7175998 | Stable protein expression systems The disclosure concerns stable expression systems for production of a protein comprising: a) a species of Acanthamoeba as a host organism; b) a DNA vector which comprises a selection marker gene which codes for a protein which, after transformation of the hos... | 02/13/2007 |
| 7064106 | Gene and use thereof A protein and DNA encoding the same are useful as preventives/remedies for diseases such as hypoglycemia, etc. The protein of the present invention is also useful as a reagent for screening a compound that inhibits the binding of the protein of the present invention... | 06/20/2006 |
| 6921825 | Adenosine A3 receptor modulators The compounds of the following formula: wherein R, R2, R3 and A have the meanings given in the specification, are endowed with selective A3 adenosine receptor antagonist activity. These... | 07/26/2005 |
| 6906043 | Rapidly soluble film preparation Disclosed is a rapidly soluble film preparation mainly comprising a drug, an edible polymer and a saccharide, a manufacturing method of which is simple, and having high elution rate. ... | 06/14/2005 |
| 6780971 | Compositions for inhibiting the aggregation pathway of α-synuclein The present invention provides methods of determining aggregation of α-synuclein, which are a hallmark of Lewy body diseases such as Parkinson's disease. Also disclosed are inhibitors of the aggregation, including magnesium and α-synuclein binding peptides. The in... | 08/24/2004 |
| 6747019 | Low dose estrogen interrupted hormone replacement therapy A hormone replacement therapy, comprising a plurality of daily doses of a pharmaceutical preparation, the doses being administered continuously and consecutively in alternating phases of three daily doses, a relatively dominant estrogenic activity phase comprising t... | 06/08/2004 |
| 6727258 | Allosteric adenosine receptor modulators The present invention relates to compounds of formula (IA): the preparation thereof, pharmaceutical formulations thereof, and their use in medicine as allosteric adenosine receptor modulators for uses including protectio... | 04/27/2004 |
| 6677338 | Serotonin transport inhibitors The present invention relates to the therapeutic use of non-amine tropane analogues that bind to the SERT to treat neuropsychiatric disorders.... | 01/13/2004 |
| 6670375 | Tropane analogs and methods for inhibition of monoamine transport New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7-substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain pr... | 12/30/2003 |
