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| Number | Title | Issue Date |
| 8148393 | Zolpidem tablets A zolpidem tablet having modified release is designed as a tablet-in-tablet dosage form. ... | 04/03/2012 |
| 8093387 | Process of making crystalline type II aripiprazole Crystalline aripiprazole Type II can be formed without solid state heat treatment. Instead a liquid is used such as in crystallizing from a solvent, especially 2-propanol, dimethyl sulfoxide, or a combination thereof with ethyl acetate, or in a solvent mediated soli... | 01/10/2012 |
| 7655806 | Process for purification of anastrozole Anastrozole can be purified by crystallization from an aqueous-based solvent system. The aqueous-based solvent system can contain dilute acid, or an alcohol or both. ... | 02/02/2010 |
| 7655798 | Process of making crystalline Type II aripiprazole Crystalline aripiprazole Type II can be formed without solid state heat treatment. Instead a liquid is used such as in crystallizing from a solvent, especially 2-propanol, dimethyl sulfoxide, or a combination thereof with ethyl acetate, or in a solvent mediated soli... | 02/02/2010 |
| 7642353 | Process of making crystalline aripiprazole Crystalline aripiprazole Form B can be formed by crystallizing from a solvent selected from 1-propanol, 2-propanol, 1-butanol, ethyl acetate, acetonitrile or a combination thereof. ... | 01/05/2010 |
| 7601741 | Process for making montelukast and intermediates therefor The reaction of methylmagnesium halide is improved by the presence of a cerium (III) salt such as cerium trichloride. The reactions are typically associated with the production of montelukast, a pharmaceutically useful compound of the following formula | 10/13/2009 |
| 7566793 | Process for resolving citalopram The (S)-citalopram content of a mixture of (R)- and (S)-citalopram can be enriched by using L-tartaric acid as the resolving agent in the presence of formaldehyde. ... | 07/28/2009 |
| 7553853 | Solid-state montelukast A solid form of a compound of formula 1: is provided. The compound of formula 1 can be obtained in solid state by precipitation from a solution containing the same. The compound is useful as leukotriene antagonist and can b... | 06/30/2009 |
| 7541470 | Processes for making pioglitazone and compounds of the processes Pioglitazone can be made via a Darzens Condensation reaction in an industrially useful process. ... | 06/02/2009 |
| 7531684 | Process for making aminoalkylphenyl carbamates and intermediates therefor A process for making aminoalkylphenyl carbamates, especially rivastigmine, can use less severe conditions using bis(p-nitrophenyl)carbonate (IX) as a phenol activator compound. ... | 05/12/2009 |
| 7501517 | Process for making montelukast and intermediates therefor A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (4) is provided. ... | 03/10/2009 |
| 7491848 | Process for making desvenlafaxine Desvenlafaxine is formed from venlafaxine by the use of a demethylating agent comprising a metal sulfide, such as sodium sulfide, and optionally selenium. ... | 02/17/2009 |
| 7476748 | Process for making montelukast and intermediates therefor A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (11) is provided. ... | 01/13/2009 |
| 7459449 | Stable salts of olanzapine Several salts of olanzapine, including olanzapine malonate, olanzapine glycolate, olanzapine maleate, and olanzapine benzoate, have been found to have favorable solid state characteristics. ... | 12/02/2008 |
| 7446116 | Montelukast amantadine salt An amantadine salt of montelukast is useful in purification of montelukast or its salts and as a pharmaceutical active ingredient. ... | 11/04/2008 |
| 7405298 | Process for making risperidone and intermediates therefor The formation of risperidone is enhanced by the use of enriched Z-isomer oxime intermediate(s) of formula (3) or (7). The oxime(s) can be isomerically enriched by a variety of techniques including the use of the novel aceti... | 07/29/2008 |
| 7364755 | Modified calcium phosphate excipient Calcium phosphate modified with a fatty acid wax in a weight ratio of 50:50 to 95:5, respectively, is useful as an excipient. ... | 04/29/2008 |
| 7365086 | Pramipexole acid addition salts The benzene sulfonic acid salts of pramipexole have moderate water solubility and are useful pharmaceutical active agents. ... | 04/29/2008 |
| 7335380 | Amlodipine free base Amlodipine free base can be formulated into a convenient oral dosage form, especially a tablet, without excessive stickiness or tablet punch residue. The amlodipine free base can be crystalline Form I or a novel Form II. Methods of making and using the amlodipine fr... | 02/26/2008 |
| 7329747 | Synthesis of olanzapine and intermediates thereof Olanzapine and salts thereof are made by a process that utilizes an N-formyl olanzapine intermediate of formula (4) or a salt thereof ... | 02/12/2008 |
| 7230016 | Pioglitazone salts, such as pioglitazone sulfate, and pharmaceutical compositions and processes using the same Water-soluble salts of pioglitazone especially pioglitazone sulfate are useful in pharmaceutical applications. ... | 06/12/2007 |
| 7217822 | Process for making cabergoline A process for making cabergoline uses silyl-protecting agents to protect the indole nitrogen atom. ... | 05/15/2007 |
| 7199247 | Amide derivative of amlodipine A derivative of amlodipine having the following formula is useful as a pharmaceutical, either alone or in combination with amlodipine, in treating angina and hypertension. ... | 04/03/2007 |
| 7186854 | Process for making bicalutamide and intermediates thereof Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent. ... | 03/06/2007 |
| 7115638 | Amide derivative of amlodipine A derivative of amlodipine having the following formula is useful as a pharmaceutical, either alone or in combination with amlodipine, in treating angina and hypertension ... | 10/03/2006 |
| 7041834 | Process for making ondansetron and intermediates thereof A process useful for making ondansetron that comprises reacting a carbazolone in a reaction mixture comprising a carbazolone of formula (2), a formaldehyde or precursor thereof, and an amine of formula (3) in a non-aqueous polar solvent and in the presence of a wate... | 05/09/2006 |
| 7018658 | Pharmaceutical pellets comprising tamsulosin Tamsulosin pellets having an advantageous release profile are formed. The pellets have an enteric coating and release less than 10% of the tamsulosin in two hours in SGF. ... | 03/28/2006 |
| 6965051 | Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith Optically impure tamsulosin including racemic tamsulosin can be resolved into optically pure (R)- or (S)-tamsulosin by the use of diastereomeric sulfonate salts of tamsulosin in a fractional crystallization technique. Racemic tamsulosin free base is a useful startin... | 11/15/2005 |
| 6919087 | Pharmaceutical compositions comprising amlodipine maleate An amlodipine maleate pharmaceutical composition is provided with good stability when formulated with a pH within the range of 5.5 to 7, when measured as a 20 wt % aqueous slurry. The stability can also be aided by making the pharmaceutical composition from amlodipi... | 07/19/2005 |
| 6900327 | 4-phenylpiperidine compounds The invention relates to a compound, and pharmaceutically acceptable salts, having the formula I: wherein: R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl ... | 05/31/2005 |
| 6858738 | Process for making amlodipine, derivatives thereof, and precursors therefor Amlodipine and related analogues thereof are prepared by the following general reaction scheme: R1 and R2 each independently represent a C1-C4 alkyl group. The process provid... | 02/22/2005 |
| 6835853 | Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith Optically impure tamsulosin including racemic tamsulosin can be resolved into optically pure (R)- or (S)-tamsulosin by the use of diastereomeric sulfonate salts of tamsulosin in a fractional crystallization technique. Racemic tamsulosin free base is a useful startin... | 12/28/2004 |
| 6830933 | Reference standards for determining the purity or stability of amlodipine maleate and processes therefor Amlodipine aspartate and amlodipine maleamide are used as reference standards or markers in determining the purity of amlodipine maleate substances and products. ... | 12/14/2004 |
| 6828339 | Amlodipine salt forms and processes for preparing them Amlodipine besylate forms are described, including amlodipine besylate hydrates and novel amlodipine besylate anhydrates. A method of making various amlodipine besylate forms from an aqueous medium as well as the use of the same as a calcium channel blocker are desc... | 12/07/2004 |
| 6818766 | Process for making bicalutamide and intermediates thereof Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent. ... | 11/16/2004 |
| 6770761 | Process for preparation of 2-amino-6 (alkyl) amino-4,5,6,7-tetrahydrobenzothiazoles A new process to obtain pramipexole and related products is described. The process involves the reaction of new compounds of formula (6), wherein R is hydrogen or acyl group, R3 and R4 are either the same and each of them represents an alkoxy g... | 08/03/2004 |
| 6717015 | Venlafaxine besylate Venlafaxine besylate compounds provide certain advantages over venlafaxine hydrochloride and are useful in forming pharmaceutical compositions and n treating venlafaxine-treatable diseases and conditions. Venlafaxine besylate can be easily formulated into an extende... | 04/06/2004 |
| 6703408 | N-formyl derivatives of paroxetine A compound or composition comprising N-formyl paroxetine of formula (1) is useful as a pharmaceutical and as a synthetic intermediate. The N-formyl paroxetine can be an impurity in paroxetine substances and methods of assaying for such an impurity are als... | 03/09/2004 |
| 6696496 | Low water-soluble venlafaxine salts Low water soluble salts of venlafaxine, especially venlafaxine maleate, are provided. Such salts can provide a variety of dosage forms including hydrogel-based extended release dosage forms.... | 02/24/2004 |
| 6686473 | Process for the production of paroxetine The synthesis of paroxetine can be made more convenient by using a solvent system comprising an aliphatic alcohol and a hydrocarbon co-solvent. The solvent system is used particularly in the hydrolysis of paroxetine phenylcarbamate and preferably uses but... | 02/03/2004 |
