Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 7399471 | Polypeptides capable of forming antigen binding structures with specificity for the Rhesus D antigens, the DNA encoding them and the process for their preparation and use Polypeptides capable of forming antigen binding structures specific for Rhesus D antigens include the sequences indicated in the FIGS. 1a to 16b. The obtained polypeptides, being Fab fragments, MAY be used directly as an active ingredient... | 07/15/2008 |
| 7288516 | Null IGF for the treatment of cancer New methods for the treatment of cancer are provided. Null IGF (IGF variants with reduced receptor binding) is administered to subjects having cancer, thereby alleviating the symptoms of the cancer. ... | 10/30/2007 |
| 7119090 | Pyrrole substituted 2-indolinone protein kinase inhibitors The present invention relates to novel pyrrole substituted 2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of prot... | 10/10/2006 |
| 7115710 | Diagnosis and treatment of PTP related disorders The present invention relates to PTP05 polypeptides and PTP10 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating ... | 10/03/2006 |
| 7112346 | Method of inducing malolactic fermentation in wine or fruit juice by direct inoculation with a non-activated started culture A selected malolactically active Ln. oenos strain which is useful for inducing malolactic fermentation in wine or fruit juice by the direct inoculation of a concentrate of a starter culture containing the strain, the strain having a survival rate of at least ... | 09/26/2006 |
| 7074589 | Nucleic acids encoding BDP-1 Nucleic acid molecules encoding full length PTP20, PCP-2, BDP1, mCLK2, mCLK3, mCLK4, and SIRP polypeptides, portions of such nucleic acid molecules, nucleic acid vectors containing such nucleic acid molecules, recombinant cells containing such nucleic acid vectors, ... | 07/11/2006 |
| 7056508 | Receptor-type phosphotyrosine phosphatase-kappa antibodies A novel receptor-type protein tyrosine phosphatase-κ (RPTPκ) protein or glycoprotein and the DNA coding therefor is expressed in a wide variety of mammalian tissues. The RPTPκ protein or glycoprotein may be produced by recombinant means. Antibodies to the protein... | 06/06/2006 |
| 7037677 | Megakaryocytic protein tyrosine kinase I The present invention relates to novel cytoplasmic tyrosine kinases isolated from megakaryoctyes (megakaryocyte kinases or MKKs) which are involved in cellular signal transduction pathways and to the use of these novel proteins in the diagnosis and treatment of dise... | 05/02/2006 |
| 7029912 | Tyrosine kinase substrate(Tks) proteins The present invention relates to novel Tks 107, Tks 113, Tks 118 and Tks 202 polypeptides, nucleotide sequences encoding the novel polypeptides, as well as various products and methods useful for the diagnosis and treatment of various related diseases and conditions... | 04/18/2006 |
| 6987113 | Tyrosine kinase inhibitors The present invention relates to novel 3-hetero-arylideneazaindolin-2-one compounds and physiologically acceptable salts and prodrugs thereof which are expected to modulate the activity of protein tyrosine kinases and therefore to be useful in the prevention and tre... | 01/17/2006 |
| 6911446 | Methods of modulating serine/threonine protein kinase function with quinazoline-based compounds The present invention is directed in part towards methods of modulating the function of serine/threonine protein kinases with quinazoline-based compounds. The methods incorporate cells that express a serine/threonine protein kinase, such as RAF. In addition, the inv... | 06/28/2005 |
| 6908984 | Megakaryocytic protein tyrosine kinase I The present invention relates to novel cytoplasmic tyrosine kinases isolated from megakaryocytes (megakaryocyte kinases or MKKs) which are involved in cellular signal transduction pathways and to the use of these novel proteins in the diagnosis and treatment of dise... | 06/21/2005 |
| 6906093 | Indolinone combinatorial libraries and related products and methods for the treatment of disease The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. ... | 06/14/2005 |
| 6897029 | MCK-10 a novel receptor tyrosine kinase The present invention relates to the novel family of receptor tyrosine kinases, herein referred to as MCK-10, to nucleotide sequences and expression vectors encoding MCK-10, and to methods of inhibiting MCK-10 activity. The invention relates to differentially splice... | 05/24/2005 |
| 6878733 | Formulations for pharmaceutical agents ionizable as free acids or free bases The present invention features formulations of indolinones which compounds are ionizable as free acids or free bases. The formulation is suitable for parenteral or oral administration, wherein the formulation comprises an ionizable substituted indolinone, and a phar... | 04/12/2005 |
| 6872699 | Truncated Flk-1 receptor protein, methods of use and a recombinant vector containing a nucleotide encoding the truncated Flk-1 protein The present invention relates to the use of ligands for the FLK-1 receptor for the modulation of angiogenesis and vasculogenesis. The invention is based, in part, on the demonstration that Flk-1 tyrosine kinase receptor expression is associated with endothelial cell... | 03/29/2005 |
| 6867033 | Treatment of papillomavirus infections This invention relates to treatment of papillomavirus infections. Primarily there is provided a method of treatment of an existing papillomavirus (PV) infection which includes the step of administration of PV VLPs selected from the group consisting of PV L1 VLPs and... | 03/15/2005 |
| 6861442 | PYK2 and inflammation The present invention relates generally to the fields of immunology and medicine, and more specifically to the field of cellular signal transduction. The present invention relates, inter alia, to methods for diagnosis, treatment, and identification of therapeutics f... | 03/01/2005 |
| 6861418 | 4-aryl substituted indolinones The present invention relates to 4-arylindolinones, as well as pharmaceutical compositions thereof, capable of modulating protein kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. The present invention also relates... | 03/01/2005 |
| 6855730 | 3-methylidenyl-2-indolinone modulators of protein kinase The present invention relates to novel 3-methylidenyl-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein k... | 02/15/2005 |
| 6849641 | Azaindole tyrosine kinase inhibitors The present invention relates to novel 3-hetero-arylideneazaindolin-2-one compounds and physiologically acceptable salts and prodrugs thereof which are expected to modulate the activity of protein tyrosine kinases and therefore to be useful in the prevention and tre... | 02/01/2005 |
| 6846839 | Methods for treating diseases and disorders related to unregulated angiogenesis and/or vasculogenesis The present invention relates to methods for treating diseases and disorders related to unregulated angiogenesis and/or vasculogenesis. More specifically, this invention relates to methods for treating diseases and disorders, such as rheumatoid arthritis, endometrio... | 01/25/2005 |
| 6844177 | Diagnosis and treatment of PTP04 related disorders The present invention relates to PTP04 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animal containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing.... | 01/18/2005 |
| 6841579 | Diagnosis and treatment of AUR1 and/or AUR2 related disorders The present invention relates to AUR1 and/or AUR2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of th... | 01/11/2005 |
| 6818440 | Diagnosis and treatment of alk-7 related disorders The present invention relates to ALK-7 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing... | 11/16/2004 |
| 6803452 | RPTP-β antibodies A new class of receptor protein tyrosine phosphatase molecule, the families of ligands that binds this new class of receptor, and uses of such receptors and ligands is described. ... | 10/12/2004 |
| 6797501 | Protein tyrosine phosphatase PTP20 and related products and methods The present invention relates to a novel polypeptide, PTP20, and to nucleic acid molecules encoding the polypeptide. The invention also relates to nucleic acid molecules encoding portions of the phosphatase, nucleic acid vectors containing PTP20 related nucleic acid... | 09/28/2004 |
| 6797513 | Nucleic acid encoding CLK2 protein kinases The present invention relates to nucleic acid molecules encoding mCLK2, mCLK3, and mCLK4 polypeptides, nucleic acid molecules-encoding portions of their amino acid sequences, nucleic acid vectors harboring such nucleic acid molecules, cells containing such nucleic a... | 09/28/2004 |
| 6797725 | Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related c... | 09/28/2004 |
| 6787156 | Controlled release composition A composition for controlled delivery of at least one active substance into an aqueous medium by erosion at a preprogrammed rate of at least one surface of the composition, comprising the active substance, the matrix being erodible in the aqueous medium in which the... | 09/07/2004 |
| 6777417 | 3-(4,5,6,7-tetrahydroindol-2-ylmethylidiene-2-indolinone derivatives as kinase inhibitors The present invention relates to certain 3-(4,5,6,7-tetrahydroindol-2-yl-methylidene)-2-indolinone derivatives that inhibit kinases, in particular Src kinase. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases ut... | 08/17/2004 |
| 6773916 | Agents and methods for treatment and diagnosis of ocular disorders A method of treating an ocular disorder is disclosed, comprising administering to a patient in need of such treatment, an effective amount of a sub-immunoglobulin antigen-binding molecule that is immuno-interactive with a target antigen associated with the disorder.... | 08/10/2004 |
| 6773891 | Hapten-carrier conjugates for treating and preventing nicotine addiction Novel hapten-carrier conjugates are capable of inducing the production of antibodies, in vivo, that specifically bind to nicotine. These conjugates comprise a nicotine hapten conjugated to an immunogenic carrier protein. The novel conjugates preserve the chirality o... | 08/10/2004 |
| 6750240 | Methods of using bis-indolylquinones The present invention relates to novel synthetic methods for the preparation of indolylquinones. The methods of the present invention are directed to synthetic reactions involving indoles and halo-quinones in solvent and in the presence of a metal carbonate. The inv... | 06/15/2004 |
| 6716575 | Diagnosis and treatment of AUR1 and/or AUR2 related disorders The present invention relates to AUR1 and/or AUR2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of th... | 04/06/2004 |
| 6716870 | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives The present invention is directed to prodrugs of certain 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to a... | 04/06/2004 |
| 6710066 | Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins Methods of detecting and treating rapidly growing exogenous cells, such as Protista, or parasites, that preferentially accumulate a photoactivatable porphyrin in which 5-aminolevulinic acid or precursor thereof is administered to the patient, or contacted to the exo... | 03/23/2004 |
| 6706709 | Indolinone derivatives as protein kinase/phosphatase inhibitors The present invention relates to certain 2-indolinone compounds which modulate the activity of protein kinases (“PKs”) and phosphatases. The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical co... | 03/16/2004 |
| 6696482 | Formulations for hydrophobic pharmaceutical agents The present invention features formulations, including liquid, semi-solid or solid pharmaceutical formulations, that improve the oral bioavailability of hydrophobic pharmaceutical agents, such as quinazoline-, nitrothiazole-, and indolinone-based compound... | 02/24/2004 |
| 6696463 | 3-heteroarylidenyl-2-azaindolinones active as protein tyrosine kinase inhibitors The invention relates to 3-heteroarylidenyl-2-azaindolinone compounds of the formula: ##STR1## wherein, A is selected from the group consisting of nitrogen, oxygen and sulfur; only one of B, D, E, F or G is nitrogen; Z is selected from the grou... | 02/24/2004 |
