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| Number | Title | Issue Date |
| 5318974 | Antiviral compounds The present invention relates to amino acid esters of pyrimidine and purine nucleosides containing an acyclic side chain, and their use in medical therapy, particularly the treatment of herpes virus infections. Also provided are pharmaceutical formulation... | 06/07/1994 |
| 5310762 | Medicaments A method for treating or preventing a Pneumocystis carinii infection in a mammal by administering a certain naphthoquinone compound or physiologically acceptable salts thereof.... | 05/10/1994 |
| 5290814 | Anti-atherosclerotic diaryl compounds The present invention is concerned with compounds of formula (I) ##STR1## wherein m is 0 or 1; W is hydrogen, a C1-16 straight, branched, or cyclic alkyl group, or a C2-16 straight, branched, or cyclic alkenyl or alkynyl group, or ... | 03/01/1994 |
| 5234913 | Antiviral nucleoside combination Synergistic combinations of nucleoside derivatives, pharmaceutical formulations containing said combinations and use of the combinations in the treatment of retroviral infections are disclosed.... | 08/10/1993 |
| 5225431 | Therapeutic substituted indole compounds and compositions thereof The present invention is concerned with compounds of formula (I) ##STR1## wherein R, R1 and R2 are independently selected from hydrogen and C1-4 alkyl; R3 and R4 are independently selected from hydrog... | 07/06/1993 |
| 5225184 | Medicaments The present invention relates to the treatment and prophylaxis of Pneumocystis carinii infections with 2-[4-(4-chlorophenyl)cyclohexyl-3-hydroxy-1,4-naphthoquinone.... | 07/06/1993 |
| 5206435 | 4-amino-2-cyclopentene-1-methanol The present invention relates to 6-substituted purine carbocyclic nucleosides and their use in medical therapy particularly in the treatment of HIV and HBV infections. The invention also relates to pharmaceutical formulations and processes for the prepara... | 04/27/1993 |
| 5206268 | Medicaments A method for treating or preventing a Pneumocystis carinii infection in a mammal by administering a certain naphthoquinone compound or physiologically acceptable salts thereof.... | 04/27/1993 |
| 5198539 | 5'-esters of 2',3'-dideoxy-3'-fluoro-5-ethynyluridine The present invention relates to a 3'-substituted pyrimidine nucleoside and its use in medical therapy, particularly in the treatment of HIV infections. Also provided are pharmaceutical formulations.... | 03/30/1993 |
| 5194450 | Anti-hypertensive sulfonanilides The present invention is concerned with compounds of formula (I) ##STR1## wherein R1 is hydrogen or C1-4 alkoxy; R2 is carbonyl, hydroxymethylene, or methylene; and R3 is hydrogen or hydroxy; and salts thereof, provi... | 03/16/1993 |
| 5185437 | Therapeutic nucleosides This invention relates to certain 6-substituted 2',3'-dideoxypurine nucleosides and pharmaceutically acceptable derivatives thereof and their use in the treatment of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections. Also provided ... | 02/09/1993 |
| 5175165 | Antiviral combinations and compounds therefor The present invention relates to novel ribonucleotide reductase inhibitors and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemotherapeutic treatment of virus ... | 12/29/1992 |
| 5175274 | Therapeutic nucleosides This invention relates to certain 2'-fluoro nucleosides and pharmaceutically acceptable derivatives thereof and their use in the treatment of HIV infections. Also provided are pharmaceutical formulations and processes for the production of the compounds a... | 12/29/1992 |
| 5175319 | Naphthoquinone derivatives Novel antiprotozoal naphthoquinones having the general formula ##STR1## (wherein either R1 is hydrogen and R2 is selected from C1-6 alkoxy, aralkoxy, C1-6 alkyl-C1-6 alkoxy, phenyl substituted by ... | 12/29/1992 |
| 5095039 | Diphenylsulfide compound and use A halogen-substituted diphenylsulfide compound is disclosed which produce a large selective inhibition of serotonin uptake in brain. This compound is useful in the treatment of depression as well as anxiety, obsessive compulsive disorders and alcoholism.... | 03/10/1992 |
| 5089500 | Therapeutic nucleosides The present invention relates to 6-substituted purine carbocyclic nucleosides and their use in medical therapy particularly in the treatment of HIV and HBV infections. Also provided are pharmceutical formulations and processes for the preparation of compo... | 02/18/1992 |
| 5087697 | Therapeutic nucleosides The present invention relates to 6-substituted purine carbocyclic nucleosides and their use in medical therapy particularly in the treatment of HIV and HBV infections. The invention also relates to pharmaceutical formulations and processes for the prepara... | 02/11/1992 |
| 5071983 | Therapeutic nucleosides This invention relates to certain derivatives of 2', 3'-dideoxycytidine and their use in medical therapy particularly in the treatment of HIV infections. Also provided are pharmaceutical formulations and processes for the manufacture of the compounds acco... | 12/10/1991 |
| 5070078 | Antiviral compounds 2',3'-Dideoxy-3'-fluoro pyrimidine nucleosides particularly 2',3'-dideoxy-3'-fluorothymidine have been found to have particularly potent activity against adenovirus infections especially those caused by adenoviruses of serotype 8. Such compounds are prefe... | 12/03/1991 |
| 5068320 | 2-amino-6-(cyclopropylamino)purine-9-ଲ-D-2',3'-dideo xyribofuranoside and its pharmaceutically acceptable salts This invention relates to certain 6-substituted 2',3'-dideoxypurine nucleosides and derivatives thereof. The compounds are useful as antivirals.... | 11/26/1991 |
| 5061708 | Therapeutic guanine esters The present invention relates to certain amino acid esters of the purine nucleoside acyclovir, pharmaceutically acceptable salts thereof and their use in the treatment and prophylaxis of herpes virus infections. The invention also includes pharmaceutical ... | 10/29/1991 |
| 5049581 | Dibenzofurans having anti-tumor activity The present invention relates to compounds of formula (I) ArCh2 R or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid additio... | 09/17/1991 |
| 5049671 | 6-substituted purine carbocyclic nucleosides The present invention relates to 6-substituted purine carbocyclic nucleosides and their use in medical therapy particularly in the treatment of HIV and HBV infections. Also provided are pharmaceutical formulations and processes for the preparation of comp... | 09/17/1991 |
| 5043339 | Antiviral compounds The present invention relates to amino acid esters of pyrimidine and purine nucleosides containing an acyclic side chain, and their use in medical therapy, particularly the treatment of herpes virus infections. Also provided are pharmaceutical formulation... | 08/27/1991 |
| 5041543 | Nucleoside and use thereof A compound 1-(3-azido-2,3-dideoxy-ଲ-D-erythro-pentofuranoxyl)-5-methyl-2(1H)-pyr imidinone and its use in a method of generating (forming, providing) 3'-azido-3'-deoxythymidine (zidovudine sometimes referred to as AZT) in the body of an animal (... | 08/20/1991 |
| 5034394 | Therapeutic nucleosides The present invention relates to 6-substituted purine carbocyclic nucleosides and their use in medical therapy particularly in the treatment of HIV and HBV infections. Also provided are pharmaceutical formulations and processes for the preparation of comp... | 07/23/1991 |
| 5021437 | 2-acetylpyridine 5-[(2-chloroanilino)thiocarbonyl]thiocarbonohydrazone compound and salts thereof The present invention relates to a novel ribonucleotide reductase inhibitor and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemotherapeutic treatment of virus... | 06/04/1991 |
| 5019577 | Novel compounds and use The present invention provides a compound selected from: N-[4-(3 -(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propylamino)-2-flurobenzoyl] -(L)-glutamic acid, N-[4-( 3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propylamino)-3-flurobenzoyl ]-(L)-glut... | 05/28/1991 |
| 4971973 | Glutamic acid derivatives The present invention provides a compound of formula (I): ##STR1## wherein Y is oxygen; R2 and R3 are the same or different and are hydrogen or C1-4 alkyl; R4 is NR11 R12 ; R11, ... | 11/20/1990 |
| 4957924 | Therapeutic valine esters of acyclovir and pharmaceutically acceptable salts thereof The present invention relates to certain amino acid exters of the purine nucleoside acyclovir, pharmaceutically acceptable salts thereof and their use in the treatment of herpes virus infections. The invention also includes pharmaceutical formulations and... | 09/18/1990 |
