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Attorney: Brown; Donald, Nielsen; Lawrence A.


Number of patents: 29
Last date: November 14, 1995

NumberTitleIssue Date
5466711Medicaments
A method for treating or preventing a Pneumocystis carinii infection in a mammal by administering a certain naphthoquinone compound or physiologically acceptable salts thereof....
11/14/1995
5453510Neuromuscular blocking agents
1R-cis,1'R-cis isomer of a 2',2'-(3,11-dioxo-4,10-dioxatridecylene)-bis(1,2,3,4-tetrahydro-6, 7-dimethoxy-2-methyl-1-veratrylisoquinolium) said, substantially free from other geometrical and optical isomers thereof. The 1R-cis,1'R-cis isomer has been...
09/26/1995
5447956Treatment of leukemia with a imidazo carbamate
Use of Methyl N-[6-(3,4,5-trimethoxybenzyloxy)imidazo [1,2-6]pyridazin-2-yl]carbamate or pharmaceutically acceptable salt to treat lymphocytic leukemia is disclosed....
09/05/1995
5432166Use of 1-(ଲ-D-arabinofuranosyl) -5-propynyluracil for lowering serum cholesterol
The use of 1-(ଲ-D-arabinofuranosyl)-5-propynyluracil or a pharmaceutically acceptable salt or physiologically labile ester thereof for lowering serum cholesterol, particularly low density lipoprotein cholesterol levels in a human subject....
07/11/1995
5427798Controlled sustained release tablets containing bupropion
A controlled sustained release tablet having at least one year shelf life and containing bupropion hydrochloride, hydroxypropyl methylcellulose and cysteine hydrochloride or glycine hydrochloride with the tablet having a surface area to volume ratio to ef...
06/27/1995
5422373Anti-atherosclerotic aryl compounds
Diaryl urea compounds having anti-atherosclerosis activity are disclosed. Preferred compounds include the compounds 1-[4-(1,2-dimethoxyethoxy)benzyl-3-(2,4-dimethoxyphenyl)-l-heptylumea and 1-heptyl-3-(2,4-dimethoxyphenyl)-l-[4-(2-methoxyethoxymethoxy)-be...
06/06/1995
5420156Pharmacologically active compound and use
1-Ethylphenoxathiin 10,10-dioxide (I) ##STR1## inhibits monoamine oxidase-A and is useful in the treatment of disorders such as depression....
05/30/1995
5395853Anti-atherosclerotic diaryl compounds
The present invention is concerned with compounds of formula (I) ##STR1## wherein m is 0 or 1; W is hydrogen, a C1-16 straight, branched, or cyclic alkyl group, or a C2-16 straight, branched, or cyclic alkenyl or alkynyl group, or Ph...
03/07/1995
5380759Methyl N-[6-(3,4,5-trimethoxybenzloxy)imidazo[1,2-b]pyridazin-2-zyl]carbamate used to treat leukemia
Methyl N-[6-(3,4,5-trimethoxybenzloxy) imidazo [1,2-6]pyridazin-2-yl]carbamate is disclosed which is used to treat leukemia....
01/10/1995
5370880Pharmaceutical formulations containing acrivastine
The invention relates to a controlled release pharmaceutical formulation for oral administration which comprises discrete units comprising acrivastine or a salt thereof coated with a mixture containing: a) a copolymer or polymer containing repeating monomer un...
12/06/1994
5371219Imidazopyridazine derivatives
Compounds of general formula (I) ##STR1## wherein R1 represents an optionally substituted carbocyclic or heterocyclic aryl group, or an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group; R2 represents an op...
12/06/1994
5241107Carbocyclic derivatives
The present invention relates to compounds of formula (I) ArCH2 R1 (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 30 carbon at...
08/31/1993
5166209Pharmacologically active compounds
This invention describes the preparation and use of anticonvulsant agents. In particular, triazolopyridine compounds are described which have utility in the treatment of epilepsy in mammals....
11/24/1992
5164395Antiviral acetyl pyridine derivative or said acetyl pyridine derivative in combination with acyclovir
The present invention relates to a novel ribonucleotide reductase inhibitor and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemotherapeutic treatment of virus...
11/17/1992
51571142',3'-dideoxy-3'-fluoro-5-ethyngluridine
The present invention relates to a 3'-substituted pyrimidine nucleoside and its use in medical therapy, particularly in the treatment of HIV infections. Also provided are pharmaceutical formulations....
10/20/1992
5153222Method of treating pulmonary hypertension with benzidine prostaglandins
The present invention is concerned with methods for the prophylaxis, treatment and diagnosis of pulmonary hypertension which comprise the administrative of an effective amount of a compound of formula (I) ##STR1## wherein a is an integer of from 1 to...
10/06/1992
5136080Nitrile compounds
A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a range of CNS disorders including cerebral ischaemic damage a...
08/04/1992
5112609Acidic formulations of t-PA
An aqueous parenteral solution of tissue-plasminogen activator, in which the pH is from 2 to 5....
05/12/1992
50950183-benzyl-1,2,4-triazolo[4,3-଱] pyrazines
3-benzyl-1,2,4-triazolo [4,3-଱] pyrazines are prepared. They are useful as anticonvulsants....
03/10/1992
5093114Treatment of human viral infections
Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the use of the 5'...
03/03/1992
5091531N-imidaxo[1,2-b]pyridazinyl carbamates
Compounds of general formula (I) ##STR1## wherein R1 represents an optinally substituted carbocyclic or heterocyclic aryl group, or an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group; R2 represents an opt...
02/25/1992
5086044Treatment of human viral infections
Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the use of the 5'...
02/04/1992
5075455Tricyclic derivatives
The present invention relates to compounds of formula (I) ArCH2 R1 (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon at...
12/24/1991
50596042-amino purine derivatives
A group of 2-aminopurine compounds, which have in the 6-position a hydrogen and in the 9-position an acyclic moiety ##STR1## wherein X is oxygen or sulphur and Y is hydrogen or CH2 OH (provided than when X is oxygen Y may not be hydrogen),...
10/22/1991
5053432Naphthoquinone derivatives
Novel antiprotozoal naphthoquinones having the general formula ##STR1## (wherein either R1 is hydrogen and R2 is selected from C1-6 alkoxy, aralkoxy, C1-6 alkyl-C1-6 alkoxy, phenyl substituted by ...
10/01/1991
50285961-(ଲ-D-arabinofuranosyl)-5-propynyluracil for treatment of VZV infections
The invention is a method for using 1-(ଲ-D-arabinofuranosyl)-5-propynyluracil or its salts as the active ingredient in pharmaceutical compositions in the treatment of varicella zoster viral infections whether expressed as chicken pox or shingles....
07/02/1991
5028628Methods of treating pulmonary hypertension
The present invention is concerned with methods for the treatment and diagnosis of pulmonary hypertension which comprise the administration of an effective amount of a compound of formula (I) ##STR1## wherein X is hydrogen or methyl; Y is --O-- or --...
07/02/1991
5017600Tricyclic derivatives
The present invention relates to compounds of formula (I) ArCH2 R1 (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon at...
05/21/1991
4874609Treatment of human viral infections
Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the use of the 5'...
10/17/1989
 
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