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| Number | Title | Issue Date |
| 8153606 | Treatment of apolipoprotein-A1 related diseases by inhibition of natural antisense transcript to apolipoprotein-A1 Oligonucleotide compounds modulate expression and/or function of an apolipoprotein (ApoA1) polynucleotides and encoded products thereof. Methods for treating diseases associated with apolipoprotein-A1 (ApoA1) comprise administering one or more Oligonucleotide compou... | 04/10/2012 |
| 7709641 | NK1 antagonists A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example variou... | 05/04/2010 |
| 7026317 | Pyrazolotriazines as CRF antagonists The present invention relates to pyrazolotriazines according to formula (I) and stereoisomers, isomers and salts thereof wherein R1-R5 are selected from certain alkyl, aryl and heteroaryl species ... | 04/11/2006 |
| 5902869 | Thermally stable ethylene/acid copolymers Ethylene/(meth)acrylic acid copolymers which have improved melt-thermal stability are described. The copolymers contain an intrachain anhydride unit derived from an additional comonomer which is an anhydride or anhydride forming comonomer, such as maleic ... | 05/11/1999 |
| 5859137 | Ionomers based on copolymers of ethylene with both mono- and dicarboxylic acids and polyamide blends containing these ionomers New ethylene/acid copolymer ionomers which contain both (meth)acrylic acid and certain dicarboxylic acid monomers are described. The polymers may be melt processed as readily as ethylene/(meth)acrylic acid dipolymer ionomers, in contrast to ethylene/acid ... | 01/12/1999 |
| 5817415 | Meltblown ionomer microfibers and non-woven webs made therefrom for gas filters Ethylene/carboxylic acid ionomers may be made, using a meltspun, and particularly meltblown process, into microfibers and thence to filter webs which are efficient gas filters for removing particles having a diameter of from 0.5 to 20 microns from a gas. ... | 10/06/1998 |
| 5789475 | Adipic acid modified-ionomers having improved properties and processability Ionomers based on ethylene/unsaturated carboxylic acid copolymers are modified with from 0.5 to 15 weight percent adipic acid. The modified-ionomers have improved melt flow and melt processing behavior over unmodified ionomers having a comparable level of... | 08/04/1998 |
| 5780153 | Meltblown ionomer microfibers and non-woven webs made therefrom for gas filters Ethylene/carboxylic acid ionomers may be made, using a meltspun, and particularly meltblown process, into microfibers and thence to filter webs which are efficient gas filters for removing particles having a diameter of from 0.5 to 20 microns from a gas. ... | 07/14/1998 |
| 5753771 | Nucleophilic amine functionalized polyolefin This invention relates to a method of producing nucleophilic amine functionalized polyolefins by reacting a polymer carrying an electrophilic functional group with a diamine having amino end-groups having different reactivities. The nucleophilic amine fun... | 05/19/1998 |
| 5744250 | Adhesion compositions for multilayer structures The present invention relates to bonding resins having excellent adhesion to polar polymers, particularly ionomers, acid copolymers and ethylene vinyl alcohol copolymer. These resins preferably contain: 1) an ethylene polymer or copolymer (ungrafted, graf... | 04/28/1998 |
| 5691351 | Bis-(Heteroarylmethoxyphenyl)cycloalkyl carboxylates as inhibitors of leukotriene biosynthesis Compounds having the structure ##STR1## where m is an integer of from one to nine; n is an integer of from one to four; W is selected from substituted or unsubstituted quinolyl, benzothiazolyl, or quinoxalyl, X is selected from C1-6 alkyle... | 11/25/1997 |
| 5668150 | Non-symmetrical bis-heteroarylmethoxyphenylalkyl carboxylates as inhibitors of leukotriene biosynthesis Compounds having the formula ##STR1## wherein W and Y are independently selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally ... | 09/16/1997 |
| 5668146 | Symmetrical bis-heteroarylmethoxyphenyliminoxyalkyl carboxylates as inhibitors of leukotriene biosynthesis Compounds having the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein W and Y at each occurrence are the same and W is selected from the group consisting of optionally substituted quinolyl, optionally substituted benzothiazolyl... | 09/16/1997 |
| 5668141 | Trans-2,6-,3,6-and 4,6-diaza-5,6,6a,7,8,12b-hexahydrobenzo[c]phenanthrene compounds as dopamine agonists A tetracyclic compound of the formula: ##STR1## wherein A and the atoms to which it is attached comprise a pyridine ring selected from: ##STR2## wherein R1, R2, and R3 are specifically defined, which compoun... | 09/16/1997 |
| 5665777 | Biphenyl hydroxamate inhibitors of matrix metalloproteinases Compounds of formula ##STR1## or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases a... | 09/09/1997 |
| 5665721 | Heterocyclic substituted cyclopentane compounds The present invention provides new heterocyclic substituted cyclopentane compounds that are useful in inhibiting adenosine kinase. The present invention also provides pharmaceutical compositions containing such compounds and methods of using such compound... | 09/09/1997 |
| 5659037 | Process for preparing chiral tetracyclic dopaminergic compounds A process for preparing a chiral tetracyclic compound of formula: ##STR1## wherein R is hydrogen or a C1 -C6 -alkyl group and Z is oxygen, sulfur or --CH.dbd.CH--, the compounds having uses as dopamine agonists. The process invo... | 08/19/1997 |
| 5629325 | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: ##STR1## or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in con... | 05/13/1997 |
| 5621133 | Dopamine agonists Novel compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters and amides thereof, wherein A is --O--, --S-- or --CR2 R8 --; R1, R2, R3, R4, R5, R | 04/15/1997 |
| 5616596 | Substituted arylalkynyl-and heteroarylalkynl-N-hydroxyurea inhibitors of leukotriene biosynthesis The invention relates to compounds having activity to inhibit lipoxygenase enzyme activity, to pharmaceutical compositions comprising these compounds, and to a medical method of treating. More particularly, this invention concerns certain substituted aryl... | 04/01/1997 |
| 5597832 | Tetracyclic compounds as dopamine agonists A tetracyclic compound of the formula: ##STR1## wherein A and the atoms to which it is attached and the optional double bond represent a mono- or di-heterocyclic ring selected from: ##STR2## wherein R1, R2, R3, R... | 01/28/1997 |
| 5399568 | Methanoanthrancenyl piperidyl antipsychotics Compounds of formula I ##STR1## wherein X and Y are H or halo; R2 is: [structures Ia, Ib or Ic;] ##STR2## R3 is selected from unsubstituted or substituted alkyl, aryl or heteroaryl groups; R4 is selected from H o... | 03/21/1995 |
