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Attorney: Brook; David E.


Number of patents: 106
Last date: January 28, 1986

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NumberTitleIssue Date
4567110High-temperature brazed ceramic joints
High-temperature joints formed from metallized ceramics are disclosed wherein the metal coatings on the ceramics are vacuum sputtered thereon....
01/28/1986
4556277Transparent heat-mirror
Transparent heat-mirrors are disclosed which are comprised of composite films. These films include a discrete and continuous layer of metallic silver sandwiched between a transparent, outer, protective, anti-reflection layer and a transparent, phase-match...
12/03/1985
4546500Fabrication of living blood vessels and glandular tissues
A method and apparatus for producing a vessel-equivalent prosthesis is described. A contractile agent such as fibroblast cells, smooth muscle cells or platelets is incorporated into a collagen lattice and contracts the lattice axially around an inner core...
10/15/1985
4539716Fabrication of living blood vessels and glandular tissues
A method and apparatus for producing a vessel-equivalent prosthesis is described. A contractile agent such as fibroblast cells, smooth muscle cells or platelets is incorporated into a collagen lattice and contracts the lattice axially around an inner core...
09/10/1985
4535058Characterization of oncogenes and assays based thereon
Experiments designed to define the differences between an oncogene isolated from human bladder cancer cells and its corresponding proto-oncogene are described herein. By a series of in vitro recombinations, the difference was initially isolated to a 350 k...
08/13/1985
4532204Mutation assays involving blood cells that metabolize toxic substances
A line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity) is disclosed. Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic sub...
07/30/1985
4522753Method for preserving porosity in porous materials
A method for preserving the porosity of porous materials is disclosed. In this method, the porous material is subjected to elevated temperature and vacuum conditions to thereby produce a dimensionally-stable, non-collapsible porous material....
06/11/1985
4518219Optical guided wave devices employing semiconductor-insulator structures
A three-dimensional optical waveguide is disclosed. This waveguide comprises a single crystal semiconductor layer grown upon an insulator which has an index of refraction lower than the semiconductor. The semiconductor layer has a thickness which provides...
05/21/1985
4514581Solar cells having ultrathin active layers
Improvements in solar cells based upon low cost semiconductors, such as amorphous silicon, are disclosed. The improved solar cells of this invention have ultrathin active semiconductor layers having a thickness between 0.1 t଱ and Lm
04/30/1985
4505266Method of using a fibrous lattice
This invention relates to the introduction of viable cells into a fibrous lattice by surgical, force-utilizing, or other manipulative techniques, all of which are referred to herein as "seeding." One embodiment comprises an autografting technique which in...
03/19/1985
4496539Method for treating cancer using galactose-specific lectins
This invention discloses a method of using galactose-binding lectins, such as Ricinus communis agglutinin I (RCAI), to kill cancer cells. RCAI has been found to severely weaken certain types of cancer cells, such as bladder carcinoma...
01/29/1985
4485096Tissue-equivalent and method for preparation thereof
A tissue-equivalent, useful in the treatment of burns or other skin wounds and in the fabrication of prostheses, is disclosed which is prepared from a hydrated collagen lattice contracted by a contractile agent, such as fibroblast cells or blood platelets...
11/27/1984
4485097Bone-equivalent and method for preparation thereof
A bone-equivalent, useful in the fabrication of prostheses, is disclosed which is prepared from a hydrated collagen lattice contracted by fibroblast cells and containing demineralized bone powder....
11/27/1984
4458678Cell-seeding procedures involving fibrous lattices
This invention relates to the introduction of viable cells into a fibrous lattice by surgical, force-utilizing, or other manipulative techniques, all of which are referred to herein as "seeding." One embodiment comprises an autografting technique which in...
07/10/1984
4456687Agents for promoting growth of epithelial cells
Certain agents are disclosed which promote growth of epithelial cells, including human epidermal cells. These agents are known to increase the level of cellular cyclic-AMP....
06/26/1984
4442203Gene amplification assay for detecting tumor promoters
A correlation between gene amplification and tumor promotion is disclosed herein. This correlation allows for a simple cellular assay that indicates whether a substance or process is a tumor promoter. This assay does not depend upon numerous biochemical p...
04/10/1984
4420873Optical guided wave devices employing semiconductor-insulator structures
A method for fabricating three-dimensional optical waveguides is disclosed. In this method, a single crystal semiconductor layer is grown upon an insulator which has an index of refraction lower than the semiconductor. The semiconductor layer is deposited...
12/20/1983
4418691Method of promoting the regeneration of tissue at a wound
This invention comprises the use of centrifugal force to introduce viable cells into a fibrous lattice, as well as fibrous lattices that are seeded with cells by the use of centrifugal force. A variety of fibrous lattices may be seeded by the methods of t...
12/06/1983
4414147Methods of decreasing the hydrophobicity of fibroblast and other interferons
A method for improving the stability and usefulness of interferon, including human fibroblast interferon, is disclosed. In this method, interferon is bonded to a non-hydrophobic substance to create a molecular complex that is less hydrophobic than untreat...
11/08/1983
4400532Cryogenically controlled direct fluorination process, apparatus and products resulting therefrom
An apparatus and process useful in direct fluorination of a variety of compositions, as well as the fluorinated compositions themselves, are disclosed. The apparatus comprises a cryogenic zone reactor, such as a packed column reactor, suitably divided int...
08/23/1983
4376228Solar cells having ultrathin active layers
Improvements in solar cells based upon low cost semiconductors, such as amorphous silicon, are disclosed. The improved solar cells of this invention have ultrathin active semiconductor layers having a thickness between 0.1 t଱ and Lm
03/08/1983
4372791Method for fabricating DH lasers
Double-heterostructure (DH) diode lasers based upon very thin epitaxial layers of Gax In1-x Asy P1-y grown on and lattice-matched to oriented InP substrates are disclosed. A preferred method for fabricating such...
02/08/1983
4357422Method of enhancing interferon production
A method for enhancing the production of interferon from normal human diploid fibroblast cells is disclosed. In this method, a distinct interferon-production phase is established in which the temperature is initially elevated for a brief period followed b...
11/02/1982
4352880Diffusion bioassay for the quantitative determination of mutagenicity
A quantitative bioassay employing the well known diffusion bioassay is described herein. The bioassay allows the calculation of the minimum concentration of a test agent which produces mutation in a tester strain of cells employed in the diffusion bioassa...
10/05/1982
4350629Procedures for preparing composite materials from collagen and glycosaminoglycan
This invention relates to crosslinked collagen and glycosaminoglycan materials, and to procedures for preparing such materials. It has been discovered that if collagen fibrils in an aqueous acidic solution are contacted with a crosslinking agent before be...
09/21/1982
4337990Transparent heat-mirror
Transparent heat-mirrors are disclosed which are comprised of composite films. These films include a discrete and continuous layer of metallic silver sandwiched between a transparent, outer, protective, anti-reflection layer and a transparent, phase-match...
07/06/1982
4334017Method for detecting cancer in mammalian tissue
An improved method for assaying for cancer by detecting ଲ-linked galactose moieties associated with cells is disclosed wherein a label specific for such moieties is added to the cells and subsequently sensed....
06/08/1982
4309225Method of crystallizing amorphous material with a moving energy beam
An improved method for crystallizing amorphous material with a moving beam of energy is disclosed. In this method, the energy beam is scanned in a manner to provide controlled, continuous motion of the crystallization front....
01/05/1982
4304866Transplantable sheets of living keratinous tissue
A method of producing transplantable sheets of living keratinous tissue by culturing keratinocytes in a culture vessel and subsequently enzymatically detaching a sheet of keratinous tissue employing an enzyme, such as Dispase, is disclosed herein....
12/08/1981
4302535Assay for mutagenesis in heterozygous diploid human lymphoblasts
An assay is disclosed for determining mutagenic damage caused by the administration of a known or suspected mutagen to diploid human lymphoblastoid cell lines. The gene locus employed for this assay is the gene for thymidine kinase, uridine kinase, or cyt...
11/24/1981
4299915Assay for mutagenesis in bacterial cells
An assay is disclosed for determining mutagenic damage caused by the administration of a known or suspected mutagen to bacterial cells such as Salmonella typhimurium. After administration of or exposure to a mutagenic agent, the bacterial cells are plated...
11/10/1981
4293654Cell culture microcarriers
Improved cell culture microcarriers, and methods for their production and use, are disclosed herein. These improved microcarriers have positive charge capacities adjusted and/or controlled within a range suitable for good cell growth. One method for produ...
10/06/1981
4287485GaInAsP/InP Double-heterostructure lasers
Double-heterostructure (DH) diode lasers based upon very thin epitaxial layers of Gax In1-x Asy P1-y grown on and lattice-matched to oriented InP substrates are disclosed. A preferred method for fabricating such...
09/01/1981
4282361Synthesis for 7-alkylamino-3-methylpyrazolo [4,3-d]pyrimidines
An improved synthesis is disclosed for 7-alkylamino-3-methylpyrazolo[4,3-d]pyrimidines, which are known to be potent cytokinin antagonists....
08/04/1981
4280954Crosslinked collagen-mucopolysaccharide composite materials
Composite materials are disclosed which are formed by contacting collagen with a mucopolysaccharide and subsequently covalently crosslinking the resultant polymer. These composite materials have a balance of mechanical, chemical and physiological properti...
07/28/1981
4281119Cryogenically controlled direct fluorination process, apparatus and products resulting therefrom
An apparatus and process useful in direct fluorination of a variety of compositions, as well as the fluorinated compositions themselves, are disclosed. The apparatus comprises a cryogenic zone reactor, such as a packed column reactor, suitably divided int...
07/28/1981
4258375Gax In1-x Asy P1-y /InP Avalanche photodiode and method for its fabrication
An improved avalanche photodiode having an active layer of Gax In1-x Asy P1-y containing a p-n junction and a window layer grown epitaxially to an n+ substrate is disclosed herein, as well as methods...
03/24/1981
4252759Cross flow filtration molding method
A cross flow filtration molding apparatus and method are disclosed which are particularly useful for forming complicated shapes from dispersions of particles in a liquid medium. Dispersion is pumped through a mold which has porous walls and a sufficient p...
02/24/1981
4248687Method of forming transparent heat mirrors on polymeric substrates
Transparent heat-mirrors are disclosed which are formed from tin-doped indium oxide films or antimony-doped tin oxide films deposited onto polymeric substrates. Low temperature deposition processes, such as ion-beam sputtering, are employed to preserve th...
02/03/1981
4248675Method of forming electrical contact and antireflection layer on solar cells
A method of applying an electrical contact and an anodic reflection coating to an n+ layer of a direct gap semiconductor device, comprising applying an anodizable metal contact to the n+ layer and thereafter anodizing the n+
02/03/1981
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