...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 6946475 | Anticancer calcium channel blockers The present invention is directed to compounds useful as cancer cell inhibitors, compositions containing such compounds and methods for inhibiting proliferation of electrically non-excitable cells. ... | 09/20/2005 |
| 6759402 | Cyclic felbamate derived compounds The present invention relates to novel felbamate derivatives and their use to treat neurological diseases such as epilepsy and to treat tissue damage resulting form ischemic events. The felbamate derivatives are modified to prevent the formation of metabolites that ... | 07/06/2004 |
| 6649746 | Biological production of stable glutamine, poly-glutamine derivatives in transgenic organisms and their use for therapeutic purposes The invention provides a bioproduction of glutamine rich peptides. These peptides are used for rehydration and nutrition therapy in patients and for enhanced nutrition in animals. The peptides may be used as individual peptides or combined with other pept... | 11/18/2003 |
| 6573060 | Methods and compositions for targeting DNA metabolic processes using aminoglycoside derivatives Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglyc... | 06/03/2003 |
| 6537791 | Mammalian DNA-dependent ATPase a polypeptides and fusions thereof Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglyc... | 03/25/2003 |
| 6531306 | Polynucleotides encoding mammalian DNA-dependent ATPase A polypeptides Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglyc... | 03/11/2003 |
| 6399302 | Signal generating oligonucleotide-based biosensor The present invention relates to oligonucleotide-based biosensors and a general method for their production and use. Specifically, the invention describes a novel signal-generating ligand complex comprising the combination of two or more aptamers linked t... | 06/04/2002 |
| 6329500 | Transforming growth factor-ଲ binding site The present invention relates to a composition and method for inhibiting TGF-ଲ activity. The composition comprises a TGF-ଲ neutralizing peptide derived from 댒 -macroglobulin that binds to TGF-ଲ and inhibits TGF-ଲ ... | 12/11/2001 |
| 6303299 | Vitro suppression as a tool for the investigation of translation initiation The invention relates to a method for studying translation initiation and for identifying potential inhibitors of translation initiation by expressing proteins in the presence of misacylated suppressor tRNAs.... | 10/16/2001 |
| 6258364 | Purified sperm surface antigen, monoclonal antibody therefor and application therefor S19 mAb, deposited under Accession Number HB-12144 at the ATCC, binds to a carbohydrate epitope of a glycoprotein found distributed over the surface of sperm. The carbohydrate nature of the epitope, its distribution over the entire sperm surface, and the ... | 07/10/2001 |