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| Number | Title | Issue Date |
| 6613162 | Multicomponent homogeneous alloys and method for making same The present application discloses a method for preparing a homogeneous ternary or quaternary alloy from a quaternary melt. The method includes providing a family of phase diagrams for the quaternary melt which shows (i) composition/temperature data, (ii) ... | 09/02/2003 |
| 6584266 | Chromophores for polymeric thin films and optical waveguides and devices comprising the same The present invention is directed to chromophores having novel electron withdrawing groups and novel bivalent cyclic bridges and to optical waveguides and optical devices having polymeric thin films which contain the novel chromophores.... | 06/24/2003 |
| 6573077 | Active site of human gamma glutamyl hydrolase Provided is the active site of human gamma glutamyl hydrolase. The active site resides in amino acid residues 110, 171, 220 and 222 of SEQ ID NO:1. Thus provided is an inactive gamma glutamyl hydrolase protein, as well as a fragment thereof. A method of i... | 06/03/2003 |
| 6562564 | Decreasing cell proliferation by decreasing levels of PP5 The invention provides a method of increasing expression of p21WAF1/Cip 1 in cells to decrease proliferation of the cells, the method comprising decreasing levels of PP5 protein in the cells. The invention further provides a method of treating ... | 05/13/2003 |
| 6548590 | Polymer and inorganic-organic hybrid composites and methods for making and using same Composites which include a polymer matrix having natural free volume therein and an inorganic or organic material disposed in the natural free volume of the polymer matrix are disclosed. In addition, methods for making a composite are described. A polymer... | 04/15/2003 |
| 6494503 | Pipe joint assembly and method for using same The present invention relates to a method for sealing an end of a pipe, to an external sealing surface. The method includes providing a pipe assembly which includes a pipe and a flange. The pipe includes a proximal pipe end and a flared end region. The fl... | 12/17/2002 |
| 6486597 | Electrically tunable low secondary electron emission diamond-like coatings and process for depositing coatings A diamond-like carbon-containing material useful as a coating for electronic devices including field emission devices and color television tubes, the coatings having both low secondary electron emission coefficients of less than unity and electrical resis... | 11/26/2002 |
| 6468642 | Fluorine-doped diamond-like coatings The invention relates to fluorine-doped coatings which include a diamond-like composition containing carbon, silicon, oxygen, hydrogen, and fluorine on various substrates. Preferred substrates include flexible substrates, precision-edged substrates, and e... | 10/22/2002 |
| 6451360 | Method for treating a subject afflicted with intestinal malabsorption A composition for human or animal consumption for supplying folate which includes a natural isomer of reduced folate, such as (6S)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic... | 09/17/2002 |
| 6410746 | Metal cataltsts and methods for making and using same Compounds having the formula: ##STR1## are disclosed. M1 and M2 are the same or different and are transition metal atoms or ions; Z2 and Z3, independently, are the atoms necessary to complete a 3-12 membered het... | 06/25/2002 |
| 6406630 | Curtain assembly for waste treatment A waste treatment apparatus (10) including one or more vertically oriented curtains (11) each formed of mesh material having a minimal aperture size of 0.001 mm, means for applying liquid waste to said curtain(s) located above said curtain (17, 15) and co... | 06/18/2002 |
| 6405069 | Time-resolved optoacoustic method and system for noninvasive monitoring of glucose The present invention is directed to a method/system of monitoring in real time changes in concentration of glucose in tissues. Laser-induced profiles of absorbed optical energy distribution in tissues are determined via measurements of spatial (in-depth)... | 06/11/2002 |
| 6355823 | Inhibitors of intestinal apical membrane na/phoshate co-transportation The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent ... | 03/12/2002 |
| 6312570 | Materials for use in electrochemical smelting of metals from ore This invention relates to a new family of materials that exhibits improved stability to the chemical environment used in metal ore reduction, and thus provides an opportunity for improving the energy use and efficiency of such processes by their use. More... | 11/06/2001 |
| 6306387 | Antigen delivery system Provided is a method of stimulating a class I-restricted immune response to a protein of interest or antigenic portion thereof in a host, as well as a protein delivery vehicle for use in the method. A nucleic acid molecule encoding the protein of interest... | 10/23/2001 |
| 6268215 | Recombinant keratinocytes The invention provides a recombinant keratinocyte having nucleic acid encoding a human 댣 integrin subunit introduced therein. This recombinant keratinocyte is able to adhere to fibrin/fibrinogen, and therefore when used in a graft procedure the rec... | 07/31/2001 |
| 6254904 | Food and vitamin preparation containing the natural isomer of reduced folates A composition for human or animal consumption for supplying folate which includes a natural isomer of reduced folate, such as (6S)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic... | 07/03/2001 |
| 6254581 | Pleural cavity drainage device A device useful for draining fluid from the pleural cavity of a patient includes two enclosed chambers. The first chamber has at its upper end a one-way directional valve. The valve, which is provided with a connector for connection with a catheter draini... | 07/03/2001 |
| 6235891 | Glucocorticoid receptor agonist and decreased PP5 A composition comprises a glucocorticoid receptor agonist and a compound which decreases levels of active human serine/threonine protein phosphatase 5 protein in cells. The glucocorticoid receptor agonist is dexamethasone and the compound is an antisense ... | 05/22/2001 |
| 6232386 | Polymer composites having an oxyhalo surface and methods for making same Oxyhalopolymer composites which include an oxyhalopolymer having free volume therein and an inorganic or organic material disposed in the free volume of the oxyhalopolymer are disclosed. Also disclosed is a surface-oxyhalogenated non-halopolymer composite... | 05/15/2001 |
| 6218515 | Cyclin E variants and use thereof The present invention is directed to nucleic acid molecules encoding a truncated human cyclin E protein, the truncated human cyclin E protein being a constitutively active form of human cyclin E protein. These truncated forms can be encoded by the nucleot... | 04/17/2001 |
| 6194378 | Fibronectin peptides-based extracellular matrix for wound healing The invention provides an extracellular matrix for wound healing comprising peptides from two or more fibronectin domains in a backbone matrix. In one embodiment, the subject invention provides a hyaluronic acid backbone derivatized with the minimal FN se... | 02/27/2001 |
| 6165440 | Radiation and nanoparticles for enhancement of drug delivery in solid tumors The present invention discloses a method/system utilizing interaction of electromagnetic pulses or ultrasonic radiation with nano- and microparticles for enhancement of drug delivery in solid tumors. The particles can be attached to antibodies directed ag... | 12/26/2000 |
| 6130207 | Cell-specific molecule and method for importing DNA into a nucleus The invention provides a cell-specific nuclear targeting molecule having a nucleic acid sequence which includes a binding site for a nuclear DNA binding protein expressed only in a specific cell type. The invention further provides a plasmid for targeting... | 10/10/2000 |
| 6071412 | Extracorporeal device containing immobilized chelator on silica substrate and use thereof In an improved process for immobilizing a chelator moiety on a silica substrate, the substrate is reacted in a liquid reaction medium with an alkyltrialkoxysilane compound having a functional group that provides an attachment site for covalently binding t... | 06/06/2000 |
| 6060279 | Interferon--induced protein The present invention is directed to an isolated nucleic acid molecule encoding an interferon--induced protein, particularly the protein designated p36. Expression vectors and host cells comprising the nucleic acid molecule are also provided, as we... | 05/09/2000 |
| 6033858 | Detection of transmissible spongiform encephalopathies Provided is a method of detecting transmissible spongiform encephalopathies. The method comprises: selecting a sample from a subject to determine whether the subject has a transmissible spongiform encephalopathy; and detecting spiroplasma-specific 16S rDN... | 03/07/2000 |
| 6020120 | Use of N-acetylcysteine to store red blood cells and a method of aging red cells with nitrogen The invention provides a method of preserving red blood cells. The method comprises treating the red blood cells with about 2 mM to about 35 mM of N-acetylcysteine. The invention further provides a method of aging red blood cells. This method comprises is... | 02/01/2000 |
| 6016689 | Aerosol-generated sol-gel derived thin films and applications thereof A sensor having a substrate overlayed with a sol-gel layer, a chemical sensing species deposited upon the sol-gel layer, and a thin film of a second sol-gel layer overlaying and entrapping the species. The effect of this sensor is that the species exhibit... | 01/25/2000 |
| 5997915 | Compositions for human and animal consumption containing reduced folates and methods for making and using same A composition for human or animal consumption for supplying folate which includes a natural isomer of reduced folate, such as (6S)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic... | 12/07/1999 |
| 5985658 | Calmodulin-based cell separation technique The invention provides a method for separating target cells from a plurality of cells which is based on a reversible high affinity interaction between two molecules. The method comprises: forming a target cell/cell binding reagent/first molecule/second mo... | 11/16/1999 |
| 5975800 | Method for directing groundwater flow and treating groundwater in situ The present invention relates to a method for treating groundwater in situ in rock or soil. An elongate permeable upgradient zone and an elongate permeable downgradient zone, each in hydraulic communication with a permeable subsurface treatment zone and h... | 11/02/1999 |
| 5977241 | Polymer and inorganic-organic hybrid composites and methods for making same Composites which include a polymer matrix having natural free volume therein and an inorganic or organic material disposed in the natural free volume of the polymer matrix are disclosed. In addition, methods for making a composite are described. A polymer... | 11/02/1999 |
| 5962235 | Human and rat gamma glutamyl hydrolase antibodies The present invention is directed to isolated nucleic acid molecules encoding gamma glutamyl hydrolase (GH). Expression vectors and host cells comprising the nucleic acid molecules are also provided, as well as methods for increasing or decreasing the exp... | 10/05/1999 |
| 5958874 | Recombinant fibronectin-based extracellular matrix for wound healing The invention provides an extracellular matrix for enhancing wound healing. The extracellular matrix comprises a recombinant fibronectin protein and a backbone matrix, wherein the recombinant fibronectin protein comprises peptides from two or more fibrone... | 09/28/1999 |
| 5958964 | Use of melatonin to prevent cytotoxic effects of amyloid beta protein The present invention is directed to a method of preventing cytotoxic effects of amyloid beta protein on cells. The method comprises exposing the cells to an effective amount of melatonin. The invention further provides a method of treating Alzheimer's di... | 09/28/1999 |
| 5948902 | Antisense oligonucleotides to human serine/threonine protein phosphatase genes Oligonucleotides are provided which are targeted to nucleic acids encoding human serine/threonine protein phosphatases and which are capable of inhibiting protein phosphatase expression. Methods of inhibiting the expression of human protein serine/threoni... | 09/07/1999 |
| 5935850 | Model for cell migration and use thereof The invention provides the development of models for cell migration, including an in vitro model and an in vivo model. The in vitro model for cell migration comprises a first extracellular matrix containing a cell (the cell which will migrate) and a secon... | 08/10/1999 |
| 5877155 | Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet glycoprotein Ib/IX complex. This peptide is called a mimot... | 03/02/1999 |
