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| Number | Title | Issue Date |
| 6248566 | Glucan having cyclic structure and method for producing the same Glucan with a degree of polymerization of 50 or more includes an inner branched cyclic structure portion and an outer branched structure portion, and methods for producing the same.... | 06/19/2001 |
| 6103525 | Hybridoma cell lines producing monoclonal antibodies that bind to human plasma hyaluronidase The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods. The method of immunoaffinity purification of the invent... | 08/15/2000 |
| 6096324 | Methods of delivering materials into the skin, and compositions used therein The invention relates to a system for delivering materials into the skin of a subject, comprising applying to the skin a composition comprising such materials in combination with an effective amount of a carrier and/or micro-carrier. The invention further... | 08/01/2000 |
| 5942512 | Method and composition for treating erectile dysfunction Lipophilic active substance composition and its use in a new method of treating erectile dysfunction by administration thereof, optionally together with a hydrophilic vehicle and optionally an antibacterial agent into the urethra.... | 08/24/1999 |
| 5925629 | Transurethral administration of androgenic agents for the treatment of erectile dysfunction A method is provided for treating erectile dysfunction in an individual. The method involves the administration of an androgenic steroid within the context of an effective dosing regimen. The preferred mode of administration is transurethral; however, the... | 07/20/1999 |
| 5908969 | Method of detecting prions in a sample and transgenic animal used for same The invention includes an artificial PrP gene, a transgenic animal containing a PrP gene of another animal or the artificial PrP gene, a hybrid non-human mammal with an ablated endogenous prion protein gene and exogenous prion protein gene, assay methodol... | 06/01/1999 |
| 5902603 | Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use High capacity drug reservoirs are provided for incorporation into transdermal drug delivery systems. The drug reservoirs are hydrogels formulated from polyurethanes crosslinked with diisocyanate crosslinking agents or cured with radiation in the presence ... | 05/11/1999 |
| 5900215 | Fiber optic sensor A method is provided for manufacturing a fiber optic sensor for detecting or measuring a parameter of interest in a sample fluid, including pH, concentration of dissolved gases such as O2 or CO2, and the like. The sensing chemistry i... | 05/04/1999 |
| 5891641 | Assay for disease related conformation of a protein An assay method is disclosed which makes it possible to determine the presence of a diseased related conformation of a protein (e.g., PrPSc) in a sample. A sample is divided into two portions and the first portion is cross-linked to a first sol... | 04/06/1999 |
| 5891461 | Transdermal administration of olanzapine Transdermal administration of olanzapine and pharmaceutically acceptable acid addition salts thereof is described. The method involves treating an individual suffering from or susceptible to psychosis, acute mania or mild anxiety states, particularly thos... | 04/06/1999 |
| 5892079 | Metallocene catalysts and associated methods of preparation and use Novel metallocene compounds are provided which are useful as polymerization catalysts, particularly in the polymerization of addition polymerizable monomers such as olefinic or vinyl monomers. Preferred polymer compositions prepared using the novel cataly... | 04/06/1999 |
| 5891668 | Mammalian tumor susceptibility genes and their uses TSG101 is a tumor susceptibility gene whose homozygous functional knock out in fibroblasts leads to transformation and the ability of these cells to form metastatic tumors in nude mice. The cellular transformation that results from inactivation of TSG101 ... | 04/06/1999 |
| 5892014 | DNA encoding a protease-activated receptor 3 Disclosed are cDNAs and genomic DNAs encoding protease-activated receptor 3 (PAR3) from mouse and human, and the recombinant polypeptides expressed from such cDNAs. The recombinant receptor polypeptides, receptor fragments and analogs expressed on the sur... | 04/06/1999 |
| 5887627 | Method for reconstructing corroded pipes A method for reconstructing corroded pipes is disclosed in which a long, new pipe can be inserted smoothly and without excessive force, into an older pipe. The method involves the insertion of a new pipe into an old pipe using a dolly to transfer the reac... | 03/30/1999 |
| 5889161 | N,N'-azobis-nitroazoles and analogs thereof as igniter compounds for use in energetic compositions Novel energetic compounds are provided comprising N,N'-azobis-nitroazoles or analogs thereof. The compounds are useful as igniter materials in a variety of energetic compositions, particularly gas-generating compositions for inflating automobile or aircra... | 03/30/1999 |
| 5888477 | Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient's lungs and the rate at which the insulin is absorbed into the blood is increased by the use of... | 03/30/1999 |
| 5884620 | Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the pat... | 03/23/1999 |
| 5885971 | Gene therapy by secretory gland expression Secretory gland cells, particularly pancreatic and salivary gland cells, are genetically altered to operatively incorporate a gene which expresses a protein which has a desired therapeutic effect on a mammalian subject. The expressed protein is secreted d... | 03/23/1999 |
| 5885540 | Reactive tricalcium phosphate compositions Methods for producing a room temperature stable, phase pure -C3 P product, and compositions derived therefrom, are provided. In the subject method, a tricalcium phosphate source is heated to a temperature sufficient to convert substantia... | 03/23/1999 |
| 5885338 | Water-based, water-fast ink compositions containing two-component binder matrix from nitrogen polymer Water-based, water-fast ink compositions are provided. The compositions contain an aqueous liquid vehicle, a colorant, e.g., a pigment, dye or stain, and a binder material capable of ionically or physically entrapping the selected colorant. The binder mat... | 03/23/1999 |
| 5886039 | Method and composition for treating erectile dysfunction Lipophilic active substance composition and its use in a new method of treating erectile dysfunction by administration thereof, optionally together with a hydrophilic vehicle and optionally an antibacterial agent into the urethra.... | 03/23/1999 |
| 5883088 | Solid dosage forms for the oral administration of gallium Disclosed are pharmaceutical compositions that comprise gallium complexes of 3-hydroxy-4-pyrones. These compositions provide enhanced gallium bioavailability particularly when orally administered as compared to the gallium bioavailability achieved by use ... | 03/16/1999 |
| 5876936 | Nucleic acid sequencing with solid phase capturable terminators Methods of enzymatic nucleic acid sequencing are provided in which solid-phase capturable chain terminators are employed. In the subject methods, sequencing fragments are generated, where the fragments comprise capturable chain terminators. The fragments ... | 03/02/1999 |
| 5877216 | Treatment of female sexual dysfunction Methods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasodilating agent is administered to the vagina or vulvar area of the individual undergoing treatment. Suita... | 03/02/1999 |
| 5877166 | Enantiomerically pure 2-aminopurine phosphonate nucleotide analogs as antiviral agents Cyclic and acyclic 2-aminopurine phosphonate nucleotide analogs useful to treat herpes viral infections are provided in enantiomerically pure form. Pharmaceutical compositions and methods for treating herpes viral infections are provided as well, as is a ... | 03/02/1999 |
| 5873358 | Method of maintaining a diabetic patient's blood glucose level in a desired range The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient's lungs and the rate at which the insulin is absorbed into the blood is increased by the use of... | 02/23/1999 |
| 5866563 | Vanadium compositions There are provided vanadium compositions for use in the treatment of hypertension, obesity and diabetes, in particular improved oral compositions comprising oxovanadium (IV) chelates of monoprotic, bidentate oxygen, oxygen and oxygen, nitrogen coordinatin... | 02/02/1999 |
| 5863716 | Treatment of plasmodium Plasmodium is shown to have an inhibition sensitive sphingomyelin synthase activity necessary for ring and early trophozoite maturation. Inhibitors can therefore be used to treat malarial infection which can differentiate between inhibition sensitive Plas... | 01/26/1999 |
| 5861388 | Steroid inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use Novel compounds useful as inhibitors of estrone sulfatase are provided. The compounds have the structural formula (I) ##STR1## wherein X and Y, or Y and Z, form an oxathiazine dioxide ring or a dihydro-oxathiazine dioxide ring, and the other various ... | 01/19/1999 |
| 5861048 | Phosphorylated saccharide and method for producing the same Phosphorylated saccharide of the present invention includes at least one phosphate group in its molecule, selected from the group consisting of glucan, mannan, dextran, agar, cyclodextrin, fucoidan, gellan gum, Locust bean gum, guar gum, tamarind gum, and... | 01/19/1999 |
| 5861240 | Isolated human herpesvirus type 8 sequences and uses thereof Isolated human herpesvirus type 8 nucleic acid sequences expressed in latently infected human cells including primary Kaposi's sarcoma cells, primary pulmonary tumor cells, and a body cavity based lymphoma cell line are disclosed. Methods of detecting HHV... | 01/19/1999 |
| 5858685 | Prostate specific antigen from benign prostatic hyperplasia and its use in diagnosis Benign prostatic hyperplasia-prostate specific antigen (BPH-PSA) and methods for its preparation are provided. Also provided are antibodies specific for BPH-PSA, and methods of their use in immunoassays for detecting the presence of BPH-PSA in a sample. T... | 01/12/1999 |
| 5855564 | Aerosol extrusion mechanism Devices for the generation of inhalable aerosols by extrusion through a porous membrane by a motor-driven cam assembly are disclosed. The device holds a drug formulation container in a drug release position. The package is comprised of a collapsible wall ... | 01/05/1999 |
| 5855678 | Fluidized bed reactor to deposit a material on a surface by chemical vapor deposition, and methods of forming a coated substrate therewith A fluidized-bed reactor for the chemical vapor deposition of a coating on a substrate surface is described. The reactor enables high rates of deposition and a highly homogeneous coating by modifying the boundary layer formed between the gasified reactive ... | 01/05/1999 |
| 5855548 | Venous flow control element for maintaining penile erection A venous flow control device is provided for assisting in the maintenance of a penile erection or in preventing urinary incontinence. The device is a tubular structure adapted to be secured in a loop configuration about the penis to provide an adjustable ... | 01/05/1999 |
| 5854230 | Antiandrogenic agents and related pharmaceutical compositions and methods of use Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R1 through R10, a and b are as defined herein. Pharmaceutical compositions and methods for using the compo... | 12/29/1998 |
| 5849803 | Method of treating erectile dysfunction with nitroglycerine Lipophilic active substance composition and its use in a new method of treating erectile dysfunction by administration of nitroglycerine together with a hydrophilic vehicle and optionally an antibacterial agent into the urethra.... | 12/15/1998 |
| 5846312 | Storage stable calcium phosphate cements Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralize... | 12/08/1998 |
| 5843961 | Method and composition for treating erectile dysfunction Lipophilic active substance composition and its use in a new method of treating erectile dysfunction by administration thereof, optionally together with a hydrophilic vehicle and optionally an antibacterial agent into the urethra.... | 12/01/1998 |
| 5840484 | Comparative gene transcript analysis A method and system for quantifying the relative abundance of gene transcripts in a biological sample. One embodiment of the method generates high-throughput sequence-specific analysis of multiple RNAs or their corresponding cDNAs (gene transcript imaging... | 11/24/1998 |
