Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 8183282 | Therapeutic uses of urolithins The subject invention is drawn to ellagitannin metabolites (e.g., urolithin) that find use in treating or preventing a neoplastic disease in a subject. ... | 05/22/2012 |
| 8183010 | Cell-free synthesis of membrane bound polypeptides Methods are provided for the utilization of bacterial cell-free extracts in the synthesis of high yields of membrane-associated polypeptides. ... | 05/22/2012 |
| 8182671 | Small volume in vitro analyte sensor and methods of making A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffus... | 05/22/2012 |
| 8182670 | Small volume in vitro analyte sensor and methods of making A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffus... | 05/22/2012 |
| 8178655 | Method and composition for crystallizing G protein-coupled receptors Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a st... | 05/15/2012 |
| 8177826 | Methods and devices for extracting thermal energy from the body core of a mammal Methods and devices for extracting thermal energy from the core body of a mammal are provided. In practicing the subject methods, a portion of the mammal, e.g. a limb or portion thereof, is placed in a sealed enclosure to produce an enclosed portion of the mammal. A... | 05/15/2012 |
| 8173849 | Therapeutic compounds A (−)-stereoisomer of formula (I): (formula I), wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, is useful as an anesthetic. ... | 05/08/2012 |
| 8173425 | Fusion partner cells Fusion partner cells that enable production of heterohybridomas even from cells of species other than mouse were produced by fusing myeloma cells derived from a first animal species with leukemia cells derived from a second animal species, which have an extra S phas... | 05/08/2012 |
| 8172762 | Simultaneous blood flow and hematocrit sensor Embodiments of the present invention provide blood flow sensors that can be used for measurement of various physiological parameters under a wide array of conditions. In some embodiments, the blood flow sensor can be implanted into a blood vessel and left in place i... | 05/08/2012 |
| 8168756 | Levetiracetam immunoassays Methods, compositions and kits are disclosed directed at levetiracetam derivatives, immunogens, signal generating moieties, antibodies that bind levetiracetam and immunoassays for detection of levetiracetam. ... | 05/01/2012 |
| 8168408 | Cytolethal distending toxins and detection of bacteria using the same as a target The present inventors succeeded in cloning the CDT genes of C. coli and C. fetus, which were previously unknown, and in determining their sequences. In addition, the inventors also developed specific primers and primers common to the two species by com... | 05/01/2012 |
| 8168074 | Modification of polymer surface with shielded plasma Methods and systems for modifying a surface of a polymer with a shielded plasma are provided. The surface may be modified to create a surface with increased crosslinking and/or a particular mechanical property, such as a coefficient of friction. A shielding arrangem... | 05/01/2012 |
| 8168052 | Transition metal complexes with bidentate ligand having an imidazole ring Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons fro... | 05/01/2012 |
| 8167889 | Use of vibration with orthopedic cements Methods of employing bone defect filling, e.g., orthopedic cements, such as calcium phosphate cements and the like, are provided. A feature of the subject methods is that vibration is employed in conjunction with the use of the cement, e.g., in preparation of the ce... | 05/01/2012 |
| 8167040 | In situ combustion in gas over bitumen formations The invention provides methods for natural gas and oil recovery, which include the use of air injection and in situ combustion in natural gas reservoirs to facilitate production of natural gas and heavy oil in gas over bitumen formations. ... | 05/01/2012 |
| 8166383 | System and method for sharing content based on positional tagging Systems and methods for sharing digital content based on positional tagging on a digital platform. For example, in one embodiment, the systems and methods generally include: (a) providing a first user with an interface to tag content on a first digital platform; (b)... | 04/24/2012 |
| 8165651 | Analyte sensor, and associated system and method employing a catalytic agent An analyte sensor for use in connection with a biofluid is described. The analyte sensor may comprise any suitable interface between the biofluid and a derivative of the biofluid and any suitable transducer of information concerning an analyte. At least one catalyti... | 04/24/2012 |
| 8163780 | Nicotine receptor agonists in stem cell and progenitor cell recruitment The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for ... | 04/24/2012 |
| 8163701 | Prodrugs of active agents Disclosed herein are prodrugs of active agents which contain at least one amine, phenol, carboxylic acid, or thiol functionality. Also disclosed herein are methods of making prodrugs of active agents, pharmaceutical compositions of prodrugs of active agents and meth... | 04/24/2012 |
| 8163305 | Targeted cross-linked nanoparticles and their use in vivo gene delivery The in vivo delivery of nucleic acids is targeted by delivery of the nucleic acid in a complex with cross-linked nanoparticles; where the nanoparticles comprise cross-linked neutral amphipathic molecules, cationic amphipathic molecules and targeting amphipathic mole... | 04/24/2012 |
| 8163164 | Small volume in vitro analyte sensor and methods of making A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffus... | 04/24/2012 |
| 8163160 | Biosensor having improved hematocrit and oxygen biases The present invention provides reagent compositions, and analyte measuring devices and methods that utilize the reagent compositions. ... | 04/24/2012 |
| 8163146 | Mediator stabilized reagent compositions for use in biosensor electrodes The claimed subject matter relates to the stabilization of 1,2-quinone mediators, especially those containing 1,10-phenanthroline quinone (PQ) and more especially transition metal complexes of PQ, in the presence of enzymes when contained in dry reagent layers for b... | 04/24/2012 |
| 8162918 | Gels with predetermined conductivity used in electroporation of tissue Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermoth... | 04/24/2012 |
| 8160670 | Analyte monitoring: stabilizer for subcutaneous glucose sensor with incorporated antiglycolytic agent An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical ... | 04/17/2012 |
| 8159670 | Method and apparatus for rapidly counting and identifying biological particles in a flow stream A method for increasing the throughput, or the precision, or both the precision and the throughput, of a flow cytometer, or of a hematology analyzer employing a flow cytometer, and for further reducing the complexity of such a cytometer or analyzer, by utilizing the... | 04/17/2012 |
| 8158081 | Analyte monitoring devices Covers for covering an opening in an analyte meter, and meters that include the same are provided. ... | 04/17/2012 |
| 8155722 | Reference electrodes having an extended lifetime for use in long term amperometric sensors The present application provides Ag/AgCl based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stabilit... | 04/10/2012 |
| 8153593 | Transglutaminase inhibitors and methods of use thereof Transglutaminase inhibitors and methods of use thereof are provided. ... | 04/10/2012 |
| 8153388 | Methods for phenotyping of leukemias Isolated populations of leukemic stem cells are provided. The cells are useful for experimental evaluation, and as a source of lineage and cell specific products, and as targets for the discovery of factors or molecules that can affect them. Detection of leukemic st... | 04/10/2012 |
| 8153376 | Means and methods for diagnosing and/or treating a subject at risk of developing heart failure The present invention relates to a method for identifying a subject at risk of developing heart failure, comprising: (a) determining the level of one or more biological markers in a biological sample of said subject; (b) comparing the level of said biological marker... | 04/10/2012 |
| 8153063 | Small volume in vitro analyte sensor and methods of making A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffus... | 04/10/2012 |
| 8148335 | De-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy The present invention generally provides compositions methods and composition relating to the diagnosis and/or treatment of cancers having a cell surface de-N-acetylated sialic acid antigen, e.g., an at least partially de-N-acetylated ganglioside and/or a de-N-acety... | 04/03/2012 |
| 8148330 | Modulation of synaptic maintenance C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical... | 04/03/2012 |
| 8148105 | Scaleable manufacturing process for cysteine endoprotease B, isoform 2 Methods are provided for the production of gram to kilogram quantities of pro-EP-B2 (proenzyme form of EP-B2) in a lyophilized form. The methods include scalable fermentation, refolding and purification processes, which processes may be combined with lyophilization ... | 04/03/2012 |
| 8148101 | Method for classifying and counting bacteria in body fluids A method for distinguishing erythroblasts from bacteria by automated hematology analyzers, such as, for example, the CELL-DYN® 4000 automated hematology analyzer and the CELL-DYN® Sapphire™ automated hematology analyzer. Bacterial cells scatter light and fluores... | 04/03/2012 |
| 8148094 | Methods and compositions for detecting the activation state of multiple proteins in single cells The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of co... | 04/03/2012 |
| 8147666 | Biosensor membranes composed of polymers containing heterocyclic nitrogens Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of an... | 04/03/2012 |
| 8143295 | Compounds having activity in correcting mutant-CFTR processing and uses thereof The invention provides compositions, pharmaceutical preparations and methods for correcting cellular processing (e.g., folding, trafficking, or post-translational modification) of a mutant-cystic fibrosis transmembrane conductance regulator protein (e.g., ΔF508 CFT... | 03/27/2012 |
| 8143241 | DNA damage repair inhibitors for treatment of cancer The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR d... | 03/27/2012 |
