Bottino; Anthony P. - US Patent Attorneys and Agents

Attorney: Bottino; Anthony P.

Number of patents: 157
Last date: May 15, 2012

Browse patents
Browse applications

Number	Title	Issue Date
8178568	Sulfone compounds which modulate the CB2 receptor Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain. ...	05/15/2012
8173638	Compounds which modulate the CB2 receptor Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treat...	05/08/2012
8163918	Azaindazole compounds as CCR1 receptor antagonists Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis.	04/24/2012
8138373	Process for the manufacture of dihydropteridinones Disclosed are processes for preparing dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and in the specification. ...	03/20/2012
8138341	Intermediate compounds useful for the manufacture of dihydropteridinones Disclosed are processes and intermediate compounds for preparing dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and in the specification...	03/20/2012
RE43115	Process for the manufacture of fused piperazin-2-one derivatives Disclosed are processes for the preparation of fused piperazin-2-one derivatives of general formula (I) wherein the groups R1 to R5, A1 and A2 have the meanings given in the claim...	01/17/2012
8067593	Process for preparing aminocrotonylamino-substituted quinazoline derivatives The invention relates to an improved process for preparing aminocrotonylamino-substituted quinazoline derivatives of general formula (I) wherein the groups Ra, Rb, Rc and Rd have ...	11/29/2011
8063065	Azaindazole compounds as CCR1 receptor antagonists Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis.	11/22/2011
8058270	Dihydropteridinones for the treatment of cancer diseases Disclosed is the use of a compound of general Formula (1), optionally in form of its tautomers, racemates, enantiomers, diastereomers and the mixtures thereof and optionally in form of the pharmacologically acceptable acid ...	11/15/2011
8048899	Compounds which selectively modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally usefu...	11/01/2011
8008327	Indazole compounds as CCR1 receptor antagonists Disclosed indazoles compounds that are useful as antagonists of CCR1 activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis...	08/30/2011
8003786	Dihydropteridinone compounds Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for...	08/23/2011
7994335	Electronically tuned ligands for asymmetric hydrogenation Disclosed is a new class of chiral bidentate ligands capable of performing asymmetric hydrogenation. Also disclosed are processes of performing asymmetric hydrogenation the chiral bidentate ligands. ...	08/09/2011
7960546	Process for preparing aminocrotonylamino-substituted quinazoline derivatives The invention relates to an improved process for preparing aminocrotonylamino-substituted quinazoline derivatives of general formula (I) wherein the groups Ra, Rb, Rc and Rd have the meanings given in the claims, as well a...	06/14/2011
7935715	Compounds which modulate the CB2 receptor Compound of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are ...	05/03/2011
7928123	Compounds which modulate the CB2 receptor Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are...	04/19/2011
7928103	Compounds which modulate the CB2 receptor Compounds of formula (I) are disclosed. Compounds according to the invention are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.	04/19/2011
7914770	Formulation for a metered dose inhaler using hydro-fluoro-alkanes as propellants An improved suspension formulation for use in a metered-dose inhaler having a hydro-fluoro-alkane propellant is described, the improvement being the controlled addition of a small quantity of water. ...	03/29/2011
7846936	Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis The present invention relates to a pharmaceutical combination for the treatment of diseases which involves cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. The invention also relates to a method for the treatment of said diseases, compri...	12/07/2010
7879873	Azaindazole compounds as CCR1 receptor antagonists Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis.	02/01/2011
7858804	Process for making cytokine inhibiting compounds containing 4- and 5-imidazolyl rings and the intermediates thereof Disclosed are processes for making compounds containing 4- and 5-imidazolyl rings, also disclosed are the intermediates useful in the processes disclosed herein. ...	12/28/2010
7816530	Piperazinyl compounds Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for...	10/19/2010
7807864	Transgenic animal as a model for fibrotic diseases Disclosed is a transgenic non-human animal with broad or cell type-specific ectopic expression of fra-2 that manifests itself in a fibrotic disease, methods for obtaining such animal and their use. Fra-2 transgenic animals, in particular mice, are useful as model sy...	10/05/2010
7807831	Dihydropteridione derivatives, process for their manufacture and their use as medicament Disclosed are new dihydropteridinones of the formula (I) wherein the groups L, R1, R2, R3, R4 and R5 have the meanings provided herein, the isomers thereof, processes f...	10/05/2010
7786299	Methods for treating diseases or conditions using dihydropteridinone compounds Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for...	08/31/2010
7759485	Process for the manufacture of dihydropteridinones Disclosed are processes for preparing dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and in the specification. ...	07/20/2010
7759347	2-benzylaminodihydropteridinones, process for their manufacture and use thereof as medicaments The present invention relates to new 2-benzylaminodihydropteridinones of general formula (I) wherein the groups R1 to R7, R10 and R11 have the meanings given in the claims and spe...	07/20/2010
7750152	Intermediate compounds for making dihydropteridinones useful as pharmaceutical compositions and processes of making the same Disclosed are dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the pharmaceutical compositions, isomers, intermediates ...	07/06/2010
7728134	Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament Disclosed are hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]Amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide: processes for preparing them and their use as pha...	06/01/2010
7727962	Powder comprising new compositions of oligosaccharides and methods for their preparation The present invention concerns powders containing a pharmaceutical active substance and a combination of excipients comprising at least one 1,4 O-linked saccharose derivative selected from the compounds: 1,4 O-linked D-Gal-saccharose (lactosucrose), 1,4 O-linked D-G...	06/01/2010
7723517	Dihydropteridione derivatives, process for their manufacture and their use as medicament Disclosed are new dihydropteridinones of the formula (I) wherein the groups L, R1, R2, R3, R4 and R5 have the meanings provided herein, the isomers thereof, processes f...	05/25/2010
7723306	Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation The present invention relates to a spray-dried powder and method for its manufacture. A spray dried powder containing a pharmaceutical active substance and one or more 1,4 O-linked saccharose derivatives chosen from the compounds: 1,4 O-linked D-gal-saccharose (lact...	05/25/2010
7714127	Process for making heteroaryl amine intermediate compounds Disclosed are processes to produce a compound of the formula (I): ...	05/11/2010
7700769	Dihydropteridione derivatives, process for their manufacture and their use as medicament Disclosed are new dihydropteridinones of the formula (I) wherein the groups L, R1, R2, R3, R4 and R5 have the meanings provided herein, the isomers thereof, processes f...	04/20/2010
7691868	Thiazolyl-dihydro-quinazoline Disclosed are thiazolyl-dihydro-quinazolines of general formula (I) wherein the groups R1 to R4 have the meanings given in the claims and specification, the isomers thereof, and processes for preparing...	04/06/2010
7651848	Method for refolding a protein A method for refolding a protein by mixing a protein solution with a refolding buffer at mixing conditions that approximate ideal mixing. The method can be carried out batch wise, in a fed-batch mode or continuously with on-line solubilization of inclusion bodies.	01/26/2010
7629460	Dihydropteridione derivatives, process for their manufacture and their use as medicament Disclosed are new dihydropteridinones of the formula (I) wherein the groups L, R1, R2, R3, R4 and R5 have the meanings provided herein, the isomers thereof, processes f...	12/08/2009
7626019	Intermediate compounds for the manufacture of fused piperazin-2-one derivatives Disclosed are processes for the preparation of fused piperazin-2-one derivatives of general formula (I) wherein the groups R1 to R5, A1 and A2 have the meanings given in the claim...	12/01/2009
7625899	Pyridodihydropyraziones, process for their manufacture and use thereof as medicaments Disclosed are pyridodihydropyrazinone compounds, processes for preparing them and their use as pharmaceutical compositions. The compounds according to the invention correspond to general formula (I), while the groups L, R	12/01/2009
7611709	1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives Disclosed are applications of oligosaccharides/oligosaccharide mixtures for the production and stabilization of pharmaceutical compositions, chiefly powders, that contain antibodies or antibody derivatives as pharmaceutical active substance. The production of powder...	11/03/2009

«First «Previous1 2 3 4 Next»Last»

PatentStorm

Quotables

PatentStorm News

Attorney: Bottino; Anthony P.