Bork; Richard W. - US Patent Attorneys and Agents

Attorney: Bork; Richard W.

Number of patents: 43
Last date: March 06, 2012

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Number	Title	Issue Date
8129343	Acylated GLP-1 compounds Protracted GLP-1 compounds and therapeutic uses thereof. ...	03/06/2012
8097698	Derivatives of GLP-1 analogs The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant. ...	01/17/2012
8030273	Protracted exendin-4 compounds Novel protracted exendin-4 compounds and therapeutic uses thereof. ...	10/04/2011
7897560	Plasma protein affinity tags Method for increasing half-life of therapeutic agents in plasma and novel polypeptide derivatives. ...	03/01/2011
7893017	Protracted GLP-1 compounds Novel protracted GLP-1 compounds and therapeutic uses thereof. ...	02/22/2011
7749955	Separation of polypeptides comprising a racemized amino acid Method for purifying a racemized polypeptide by ion-exchange chromatography. ...	07/06/2010
7576059	Peptide derivatives A pharmacologically active peptide hormone derivative in which the parent peptide hormone has been modified by introducing either a lipophilic substituent, W, in the N-terminal amino acid or a lipophilic substituent, Z, in the C-terminal amino acid of the parent pep...	08/18/2009
7456276	Peptide purification by means of metal ion affinity chromatography A polymer substrate functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group, the cyclic ligand group comprising at least 3 metal ion coordinating donor atoms independently selected from the group consisting of N, O and...	11/25/2008
7446091	Methods and preparations for curing clinically ill patients This invention relates to a life saving medicament for critically ill patients and a method of treatment. The composition is a pharmaceutically effective amount of a blood glucose regulator which is used to control the blood glucose level. ...	11/04/2008
7387996	Formulations of insulin Stable insulin formulations can be prepared by mixing a monomeric insulin and a soluble acylated insulin analog. ...	06/17/2008
7276590	Ion exchange chromatography of proteins and peptides The present invention relates to an ion exchange chromatography process for purifying a peptide from a mixture containing the peptide and related impurities, and to an industrial method including such ion exchange chromatography process. ...	10/02/2007
7273921	Method for producing acylated peptides The present invention provides a method for acylating one or more amino groups of a peptide where the acylation reaction is to be performed in an aqueous mixture containing less than 10% w/w aprotic polar solvent. ...	09/25/2007
7235627	Derivatives of GLP-1 analogs The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant. ...	06/26/2007
7235538	Heterocyclic compounds, which are inhibitors of the enzyme DPP-IV The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV, which are of formula I wherein each n is one or two independently and R1, R2, R3	06/26/2007
7229964	Insulin derivatives The present invention relates to insulin derivatives in which a lipophilic group having from 12 to 40 carbon atoms is attached to the α-amino group of the N-terminal amino acid in the B-chain or to the carboxy group of the C-terminal amino acid in the B-chain have ...	06/12/2007
7229554	Purification process comprising microfiltration at elevated temperatures Process for microfiltration at elevated temperature. ...	06/12/2007
7226990	Extendin derivatives The present invention relates to novel derivatives of exendin-4 or exendin-4 fragments, wherein the derivatives have a lipophilic substituent attached, optionally via a spacer, to an amino acid residue, which is not the N-terminal or C-terminal amino acid residue of...	06/05/2007
7220877	Compounds, their preparation and use A novel class of dicarboxylic acid derivatives, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful i...	05/22/2007
7208497	Substituted piperazines and diazepanes A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of dis...	04/24/2007
7192952	Heterocyclic compounds that are inhibitors of the enzyme DPP-IV The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV of formula I, pharmaceutical compositions comprising the compounds and the use of such compounds for and the manufacture of medicaments for treating diseases that a...	03/20/2007
7192768	Synchronization of the cytoplasmatic and the nuclear maturation of oocytes The present invention relates to a method for in vitro maturation of oocytes comprising the steps of: (a) culturing one or more GV oocytes in a culture medium, the culture medium comprising a nuclear maturation inhibiting substance and comprising one or...	03/20/2007
7175055	Frontloaded injection device A frontloaded injection device that includes a cartridge holder into which a replaceable cartridge containing a fluid is inserted. The cartridge holder includes a closing element such as a pair of claws which are displaceable in a radial direction. The closing eleme...	02/13/2007
7134550	Needle magazine A needle magazine for storing a plurality of needle assemblies and for selectively dispensing said needle assemblies there from. The needle magazine comprises a cylinder-shaped base member with an upper surface and a bottom surface. These two surfaces are parallel t...	11/14/2006
7133329	Device with time indicating means The invention relates to a timer device capable of performing one or more control actions in response to the time lapsed since a user initiated action took place. The timer device comprises contact means operatable between two conditions, timer means, and means for ...	11/07/2006
7129268	Peroxisome proliferator activated receptor-active arylene acetic acid derivatives Novel compounds of the general formula (I), wherein Ar, R1, R2, X1, X2, Y1, Y, and Z are as defined in the specification, the use of these compounds as pharm...	10/31/2006
7115624	Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 The present invention provides a method of inhibiting a member of a family of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPα, PTPε, PTPμ, PTPδ, PTPσ, PTPζ, PTPβ, PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR, and HePTP ...	10/03/2006
7101898	Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes Novel amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositio...	09/05/2006
7091245	Compounds, their preparation and use Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in th...	08/15/2006
7087408	Method for making insulin precursors and insulin precursor analogs Novel insulin precursors and insulin precursor analogs having a mini C-peptide comprising at least one aromatic amino acid residue have an increased folding stability. The novel insulin precursors and insulin precursor analogs can be expressed in yeast in high yield...	08/08/2006
7078479	Pharmaceutical composition comprising factor VII polypeptides and alpha2-antiplasmin polypeptides The present invention relates to a composition comprising factor VII or a factor VII-related polypeptide and alpha2-antiplasmin or an alpha2-antiplasmin-related polypeptide, and the use thereof for treating bleeding episodes. ...	07/18/2006
7067530	Compounds, their preparation and use Novel compounds of general formula (I), the use of these compounds as medicaments, pharmaceuticaly compositions comprising the compounds and methods of treatment employing these compounds and compostiones. The present compounds may be useful in the treatment and/or ...	06/27/2006
7067517	Use of compounds for decreasing activity of hormone-sensitive lipase Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may...	06/27/2006
7064145	Inhibition of beta cell degeneration Methods for preventing beta cell degeneration, such as necrosis or apoptosis of beta cells in a subject, comprising administering a DPP-IV inhibitor to a subject in need thereof. The invention furthermore relates to a method for increasing the number and/or the size...	06/20/2006
7064135	Substituted piperidines A novel class of substituted piperidines, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and disor...	06/20/2006
7037905	Pharmaceutical use of boronic acids and esters thereof Use of compounds to inhibit hormone-sensitive lipase, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, method of treatment employing these compounds and compositions, and novel compounds. The present co...	05/02/2006
6951878	Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl modulators of protein tyrosine phosphatases (PTPases) The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PT...	10/04/2005
6939880	Compounds with growth hormone releasing properties Compounds of peptide mimetic nature having the general formula I wherein a and b are independently 1 or 2, R1 and R2 are independently H or C1-6alkyl, G and J are independently, inter a...	09/06/2005
6919315	Compounds with growth hormone releasing properties Disclosed are compounds of formula I formula I wherein R1, R2, R5, R6, R7, R8, G, J, L, M, a, b, c, d, e, and f are as defined in the specification, and...	07/19/2005
6908926	Substituted imidazoles, their preparation and use Disclosed is a novel class of substituted imidazole compounds, pharmaceutical compositions containing them and uses of these compounds in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, these compoun...	06/21/2005
6906060	Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines Novel substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employin...	06/14/2005

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Attorney: Bork; Richard W.