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| Number | Title | Issue Date |
| 8178496 | Photoreactive regulator of glutamate receptor function and methods of use thereof The present invention provides a synthetic regulator of glutamate receptor function, which regulator is a light-sensitive (photoreactive) regulator. The present invention further provides a light-regulated glutamate receptor that includes a subject synthetic regulat... | 05/15/2012 |
| 8178338 | Inducible expression vectors and methods of use thereof The present invention provides nucleic acids that include a promoter that is inducible by a transcriptional activator protein; and a nucleotide sequence that encodes the transcriptional activator protein. The present invention provides expression vectors that provid... | 05/15/2012 |
| 8178299 | Method to determine the risk for side effects of an SSRI treatment in a person A new method is found to determine an increased risk for side effects of an SSRI treatment in a person by genotyping the person for the presence of the 102 C/C DNA sequence in the 5-HT2A receptor gene. This provides for a method to improve the treatment o... | 05/15/2012 |
| 8163980 | Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof The present invention provides isolated nucleic acids comprising nucleotide sequences encoding isoprenoid modifying enzymes, as well as recombinant vectors comprising the nucleic acids. The present invention further provides genetically modified host cells comprisin... | 04/24/2012 |
| 8163893 | Pseudotyped retroviral vectors and methods of use thereof The present invention provides nucleic acids encoding recombinant envelope proteins; and packaging cells comprising the nucleic acids, which packaging cells provide for encapsidation of recombinant retroviral vectors. The present invention provides producer cells th... | 04/24/2012 |
| 8163780 | Nicotine receptor agonists in stem cell and progenitor cell recruitment The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for ... | 04/24/2012 |
| 8163548 | Recombinant bicistronic flaviviruses and methods of use thereof The present invention provides recombinant bicistronic flaviviruses, particularly live attenuated recombinant bicistronic flavivirus, which comprise, in order from 5′ to 3′, a viral 5′UTR, an ORF encoding all viral proteins, an internal ribosome entry site, an... | 04/24/2012 |
| 8158582 | Methods for treatment of insulin-like growth factor-1 deficiency The present invention provides methods and compositions for increasing the growth rates, alleviating the symptoms, or improving the metabolism of human patients having an endocrine disorder characterized by partial endogenous growth hormone activity or signaling. Th... | 04/17/2012 |
| 8158383 | Methods of generating protein variants The present invention provides methods of designing and generating polypeptide variants that have altered properties compared to a parent polypeptide. The present invention further provides a computer program product for carrying out the design of a variant polypept... | 04/17/2012 |
| 8153380 | Gene expression markers for colorectal cancer prognosis A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the su... | 04/10/2012 |
| 8153379 | Gene expression markers for colorectal cancer prognosis A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the su... | 04/10/2012 |
| 8153378 | Gene expression markers for colorectal cancer prognosis A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the su... | 04/10/2012 |
| 8148076 | Gene expression profiling of EGFR positive cancer The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing ... | 04/03/2012 |
| 8143372 | Synthetic regulators of ferritin protein nanocage pores and methods of use thereof The present invention provides synthetic regulators of ferritin pores, and compositions comprising the regulators. The regulators function to reduce ferritin demineralization rates. The regulators are useful for treating inflammatory conditions. The present inventio... | 03/27/2012 |
| 8133862 | Methods for treatment of insulin-like growth factor-1 (IGF-1) deficiency The present invention provides methods and compositions for increasing the growth rates, alleviating the symptoms, or improving the metabolism of human patients having insulin-like growth factor-1 deficiency (IGFD). The invention relates to methods comprising admini... | 03/13/2012 |
| 8133666 | Method for identifying agents capable of inhibiting APOBEC3C activity in HIV-infected cells The present invention provides methods of identifying agents that reduce a level of active APOBEC3C in a cell. The present invention provides agents that reduce a level of active APOBEC3C in a cell; and compositions comprising the agents. The present invention furth... | 03/13/2012 |
| 8124389 | Crystal structure of aldehyde dehydrogenase and methods of use thereof The present disclosure provides a crystal structure of aldehyde dehydrogenase (ALDH) with a modulator of ALDH bound thereto. The present disclosure provides a computer readable medium comprising atomic coordinates for an ALDH polypeptide and a modulator bound to a s... | 02/28/2012 |
| 8114853 | Methods of treating smooth muscle cell disorders The present invention provides methods of detecting cells showing smooth muscle differentiation. The present invention further provides methods of detecting tumor cells. The present invention further provides compositions and methods for treating smooth muscle cell ... | 02/14/2012 |
| 8114843 | Photoreactive regulator of protein function and methods of use thereof The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and me... | 02/14/2012 |
| 8114645 | Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels The present invention provides methods of increasing production of an isoprenoid or an isoprenoid precursor in a host cell, the methods generally involving modulating the level of activity of a fatty acid biosynthetic pathway enzyme in the host cell and/or culturing... | 02/14/2012 |
| 8106152 | Antimicrobial composition The present invention relates to novel antimicrobial composition comprising a peptide which can be obtained from the milk protein casein or chemically synthesised or produced by recombinant DNA technology and a divalent cation. ... | 01/31/2012 |
| 8101399 | Artemisinic epoxide and methods for producing same The present invention provides artemisinic epoxide, and methods of synthesizing artemisinic epoxide in a genetically modified host cell. The present invention further provides methods for producing artemisinin. The present invention further provides variant enzymes ... | 01/24/2012 |
| 8097438 | Nucleic acids encoding modified cytochrome P450 enzymes and methods of use thereof The present invention provides nucleic acids comprising nucleotide sequences encoding modified cytochrome P450 enzymes; as well as recombinant vectors and host cells comprising the nucleic acids. The present invention further provides methods of producing a function... | 01/17/2012 |
| 8093353 | Agents for treatment of HCV and methods of use An amphipathic helix at the approximate N-terminus of Hepatitis C virus (HCV) nonstructural proteins mediates the association of these proteins with cytoplasmic membranes in infected cells. This association is essential for replication. Thus, assessing the ability o... | 01/10/2012 |
| 8076496 | Chemoselective ligation The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between... | 12/13/2011 |
| 8071074 | Preventing airway mucus production by administration of EGF-R antagonists Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks th... | 12/06/2011 |
| 8048844 | Preventing airway mucus production by administration of EGF-R antagonists Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks th... | 11/01/2011 |
| 8034565 | Gene expression markers for breast cancer prognosis The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer. ... | 10/11/2011 |
| 8034350 | Methylated tat polypeptides and methods of use thereof The present invention provides isolated methylated Tat peptides; and compositions comprising the peptides. The present invention further provides isolated antibodies specific for a Lys-51-methylated Tat polypeptide. Also provided are methods of identifying agents th... | 10/11/2011 |
| 8029995 | Gene expression markers for colorectal cancer prognosis A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the su... | 10/04/2011 |
| 8026060 | Gene expression markers for colorectal cancer prognosis A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the su... | 09/27/2011 |
| 8008003 | Gene expression profiling of EGFR positive cancer The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing ... | 08/30/2011 |
| 7964598 | ApoE4 domain interaction inhibitors and methods of use thereof The present invention provides compounds that inhibit apoE4 domain interaction; and compositions, including pharmaceutical compositions, comprising the compounds. The present invention provides methods of treating apoE4-related disorders. The methods generally invol... | 06/21/2011 |
| 7951538 | Method to determine the risk for side effects of an SSRI treatment in a person A new method is found to determine an increased risk for side effects of an SSRI treatment in a person by genotyping the person for the presence of the 102 C/C DNA sequence in the 5-HT2A receptor gene. This provides for a method to improve the treatment o... | 05/31/2011 |
| 7951367 | Methods and compositions for reducing amyloid beta levels The present invention provides a method of increasing cathepsin B-induced cleavage of amyloid-β (Aβ) peptide in a cell or tissue, the method generally involving contacting the cell or tissue with an agent that increases the level of cathepsin B in the cell or tiss... | 05/31/2011 |
| 7939626 | Chemoselective ligation The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between... | 05/10/2011 |
| 7939261 | Expression profile algorithm and test for cancer prognosis The present invention provides a noninvasive, quantitative test for prognosis determination in cancer patients. The test relies on measurements of the tumor levels of certain messenger RNAs (mRNAs). These mRNA levels are inserted into a polynomial formula (algorithm... | 05/10/2011 |
| 7930104 | Predicting response to chemotherapy using gene expression markers The present invention provides gene expression information useful for predicting whether a cancer patient is likely to have a beneficial response to treatment with chemotherapy, comprising measuring, in a biological sample comprising a breast tumor sample obtained f... | 04/19/2011 |
| 7927794 | Methods for identifying a biosynthetic pathway gene product The present invention provides isolated, genetically modified host cells, where a host cell is genetically modified with a nucleic acid that includes a nucleotide sequence encoding a biosynthetic pathway enzyme. Synthesis of the enzyme in the host cell results in co... | 04/19/2011 |
| 7923582 | Chemoselective ligation The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between... | 04/12/2011 |
