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| Number | Title | Issue Date |
| 4069322 | Pro-drugs for the improved delivery of certain selected anti-inflammatory steroids Transient, pro-drug forms of conventional anti-inflammatory steroids are disclosed.... | 01/17/1978 |
| 4065566 | N-Nicotinoyl-3,4-dinicotinoyloxy-L-phenylalanine and derivatives pharmaceutical compositions and methods containing same There is provided, novel, transient pro-drug forms of L-DOPA (3,4-dihydroxy-L-phenylalanine), having the formula: ##STR1## wherein R represents a hydrogen atom, an acyl group, a ##STR2## group, a --CO-pyridyl group, and a --CO--R3 gro... | 12/27/1977 |
| 4061753 | Treating psoriasis with transient pro-drug forms of xanthine derivatives Compounds of the formula: ##STR1## wherein R, which may be the same or different, represents a member selected from the group consisting of --CH3, --C2 H5, --C3 H7, iso--C3 H7 | 12/06/1977 |
| 4061722 | Selected quaternary ammonium salts of pilocarpine useful in reducing intraocular pressure in warm-blooded animals Compounds of the formula: ##STR1## wherein R represents a member selected from the group consisting of a hydrogen atom, a C1 -C20 open chain or cyclo alkyl group, a C1 -C20 alkoxyalkyl group, a C1 | 12/06/1977 |
| 4049818 | 3-Chloro-1,3-oxazines or oxazolidines as antibacterial agents There is provided, novel 3-chloro-tetrahydro-1,3-oxazine or oxazolidine compounds, exhibiting antibacterial activity and being of low chlorine potential of the formula: ##STR1## wherein each of R1 and R2, which may be the same o... | 09/20/1977 |
| 4046899 | Labile quaternary ammonium salts useful in binding bile acids in warm-blooded animals Free and conjugated bile acids are effectively bound in warm-blooded animals by administering thereto, a therapeutically effective bile acid binding amount of a quaternary ammonium compound having the formula: ##STR1## wherein N represents a tertiar... | 09/06/1977 |
| 4045578 | N-chloro-amino acid derivatives exhibiting antibacterial activity There is provided, a novel class of compounds exhibiting antibacterial activity, said compounds having the formula: ##STR1## wherein X and Y each represent a member which may be the same or different selected from the group consisting of H and Cl wit... | 08/30/1977 |
| 4036843 | Certain chloroamino esters of pyridine carboxylates and derivatives thereof There is provided, a novel class of compounds exhibiting antibacterial activity and having the formula: ##STR1## wherein X and Y each represent a member which may be the same or different selected from the group consisting of H and Cl with the provis... | 07/19/1977 |
| 4036845 | Novel transient acyl derivatives of phenylbutazone There is provided, novel, transient, pro-drug forms of phenylbutazone and oxyphenbutazone having the following formulas wherein the terms R, R2, R4, R5, X and Y are defined infra: ##STR1## The above-identified compoun... | 07/19/1977 |
| 4035405 | Novel synthesis for preparing the hydrochloride salt of selected catecholamine derivatives Compounds of the formula: ##STR1## wherein R represents a straight or branched C1 -C5 alkyl group; and R1 in each occurrence represents an acyl member which is alkanoyl having 1-22 carbon atoms, alkenoyl having one or... | 07/12/1977 |
| 4035507 | Novel, transient pro-drug forms of L-DOPA to treat Parkinson's disease There is provided, novel, transient pro-drug forms of L-DOPA (3,4-dihydroxy-L-phenylalanine), having the formula: ##STR1## wherein R represents a hydrogen atom, an acyl group, ##STR2## group, a -CO-pyridyl group, and a -CO-R3 group, w... | 07/12/1977 |
| 4028368 | Novel intermediates useful in the synthesis of optically active m-acyloxy--[(methylamino)methyl]benzyl alcohols Optically and therapeutically active compounds of the formula: ##STR1## wherein R represents a member selected from the group consisting of a straight or branched alkyl group of from one to twenty carbon atoms (C1 -C5 being pref... | 06/07/1977 |
| 4021546 | Pro-drug forms of digoxin and method of preparing and using same There is provided, a novel pro-drug form of digoxin having the following formula: ##STR1## wherein R represents a member selected from the group consisting of a hydrogen atom, a residue of any naturally occurring amino acid, and a ##STR2## ... | 05/03/1977 |
| 4018925 | Method of arresting bacterial growth with certain selected dichloro-2,2,5,5-tetrasubstituted-3-6-piperazinediones There is provided, novel N-chloramine compounds of the 1,4-dichloro-2,2,5,5-tetrasubstituted-3,6-piperazinedione type, having the formula: ##STR1## WHERE R1, R2, R3, R4, which may be the same or differ... | 04/19/1977 |
| 4009178 | Brominating and oxidizing agent and method of using same There is provided a brominating and oxidizing agent of the formula: ##STR1## wherein R1, R2, R3 and R4 which may be the same or different, represents a member selected from the group consisting of a hydroge... | 02/22/1977 |
| 4000293 | Method of inhibiting bacterial growth with certain selected 3-chloro-2-oxazolidinones Antibacterially effective 3-chloro-2-oxazolidinones are prepared by chlorination of an appropriate 2-oxazolidinone either with elemental chlorine in an aqueous medium or with a mono-, di- or trichloroisocyanuric acid (cyanuric chloride) in an inert organi... | 12/28/1976 |
| 3998799 | Novel, transient pro-drug forms of L-DOPA There is provided, novel, transient pro-drug forms of L-DOPA (3,4-dihydroxy-L-phenylalanine), having the formula: ##STR1## wherein n represents an integer of from 2 to 50 with respect to formula (V-A), and wherein n represents an integer of from 1 to... | 12/21/1976 |
| 3998815 | 1-Hydrocarbonoyloxymethyl-3-carbamoyl or 3-carboethoxy-pyridinium salts Labile quaternary ammonium salts of the following formula (I) and (II) are provided: ##STR1## wherein N represents a tertiary aliphatic amine; wherein N represents an aromatic amine; wherein R represents a member selected from the group consis... | 12/21/1976 |
| 3989711 | Soft quaternary surface active agents exhibiting antibacterial activity Soft quaternary surface active agents having the formula: ##EQU1## wherein ##EQU2## represents a tertiary open chain or cyclic aliphatic amine; wherein ##EQU3## represents an aromatic amine; wherein R represents a member selected from ... | 11/02/1976 |
| 3966749 | Novel synthesis of optically active m-acyloxy--[(methylamino)methyl]benzyl alcohols, the pharmaceutically acceptable acid addition salts thereof and intermediate useful in the preparation thereof Optically and therapeutically active compounds of the formula: ##SPC1## Wherein R represents a member selected from the group consisting of a straight or branched alkyl group of from one to twenty carbon atoms (C1 -C5 being preferred... | 06/29/1976 |
| 3966796 | N-chloro-amino acid derivatives activity There is provided, a novel class of compounds exhibiting antibacterial activity, said compounds having the formula: ##EQU1## wherein X and Y each represent a member which may be the same or different selected from the group consisting of H and Cl wit... | 06/29/1976 |
| 3962447 | Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and method of using same There is provided, novel pro-drug forms of pyridinium aldoxime type cholinesterase reactivators, namely, dihydropyridinium aldoximes, having the formula: ##SPC1## Wherein R represents a member selected from the group consisting of an alkyl (C1 | 06/08/1976 |
| 3961041 | Effervescent enteric coated L-dopa formulation and method of using the same Therapeutic levels of L-DOPA are achieved by orally administering a pharmaceutical effervescent-enteric coated tablet comprising: A. a member selected from the group consisting of L-DOPA or a derivative thereof capable of enzymatically cleaving and reverting t... | 06/01/1976 |
| 3959485 | Method of reducing intraocular pressure in warm-blooded animals The intraocular pressure of a warm-blooded animal is substantially reduced by administering topically to the eye thereof, a therapeutically effective amount of a compound of the formula: ##SPC1## Or a pharmaceutically acceptable acid addition salt thereof... | 05/25/1976 |
| 3957803 | Certain transient pro-drug forms of phenylbutazone Transient, pro-drug forms of phenylbutazone and oxyphenbutazone, which are 1,2-diphenyl-4-butyl-5-oxy-4-pyrazolin-3-one derivatives, are disclosed. These compounds exhibit anti-inflammatory activity in warm-blooded animals. Upon administration to warm-blooded ... | 05/18/1976 |
| 3956490 | Administration of alkaline earth metal salts of salicylamide Alkaline earth metal salts of salicylamide are administered in solid oral dosage forms with substantially improved analgesic, anti-inflammatory, antipyretic and sedative results as compared with salicylamide. Highest blood levels are obtained by administe... | 05/11/1976 |
| 3954985 | Method for inhibiting bacterial growth with certain selected 3-chloro-tetrahydro-1,3-oxazines or oxazolidines There is provided, novel 3-chloro-tetrahydro-1,3-oxazine or oxazolidine compounds, exhibiting antibacterial activity and being of low chlorine potential of the formula: ##SPC1## Wherein each of R1 and R2, which may be the same or dif... | 05/04/1976 |
| 3950521 | Administration of alkali metal salicylamide salts Alkali and alkaline earth metal salts of salicylamide are administered in solid oral dosage forms with substantially improved analgesic, anti-inflammatory, antipyretic and sedative results as compared with salicylamide. Highest blood levels are obtained b... | 04/13/1976 |
| 3939253 | Novel, transient pro-drug forms of l-dopa useful in the treatment of parkinson's disease There is provided, novel, transient pro-drug forms of L-DOPA (3,4-dihydroxy-L-phenylalanine), having the formula: ##SPC1## Wherein R represents a member selected from the group consisting of a hydrogen atom, a --COCH3 group, a --COC2... | 02/17/1976 |
| 3936466 | 3-Chloro-tetrahydro-1,3-oxazines or oxazolidines spiro substituted There is provided, novel 3-chloro-tetrahydro 1,3-oxazine or oxazolidine compounds, exhibiting antibacterial activity and being of low chlorine potential of the formula: ##EQU1## WHEREIN EACH OF R1 and R2, which may be the same o... | 02/03/1976 |
| 3931213 | 3-Chloro-2-oxazolidinones Antibacterially effective 3-chloro-2-oxazolidinones are prepared by chlorination of an appropriate 2-oxazolidinone either with elemental chlorine in an aqueous medium or with a mono-, di- or trichloroisocyanuric acid (cyanuric chloride) in an inert organi... | 01/06/1976 |
