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| Number | Title | Issue Date |
| 8183271 | Tetrazole derivatives and their use for the treatment of cardiovascular diseases The present application relates to novel tetrazole derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the ... | 05/22/2012 |
| 8168758 | Anti-MN antibodies and methods of using same The invention provides antibodies having an antigenic binding site specifically directed against an MN protein, and methods for using such antibodies in treating and diagnosing an MN-related disorder. ... | 05/01/2012 |
| 8101615 | 1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors The invention relates to novel heterocyclic derivatives of the general formula (I), processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infar... | 01/24/2012 |
| 8097629 | Dihydropyridinone derivatives The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failur... | 01/17/2012 |
| 8063234 | Substituted 7-sulfanylmethyl-, 7-sulfinylmethyl- and 7-sulfonylmethylindoles and the use thereof The present application relates to novel 7-sulfanylmethyl-, 7-sulfinylmethyl- and 7-sulfonylmethylindole derivatives, processes for the preparation thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases, and the use thereof... | 11/22/2011 |
| 7960387 | 2-(3-phenyl-2-piperazinyl-3,4-dihydroquinazolin-4-yl)acetic acids as antiviral agents, especially against cytomegaloviruses The invention relates to dihydroquinazolines and methods for the production thereof, the use thereof in the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments in the treatment and/or prophylaxis of diseases, esp... | 06/14/2011 |
| 7893210 | Process for renaturation of recombinant, disulfide containing proteins at high protein concentrations in the presence of amines A method for renaturation of proteins comprising adding to a solution of denatured, chemically modified or reduced proteins a refolding buffer containing a primary, secondary or tertiary amine. Said method has been applied, for example, to interleukin-4 and bovine p... | 02/22/2011 |
| 7855219 | Substituted 2-oxy-3,5-dicyano-4aryl-6-aminopyridines and use thereof This invention relates to compounds of formula (I) in which the variable groups are as defined in the text and claims. A pharmaceutical composition and methods of using these materials in treatment of various conditions are... | 12/21/2010 |
| 7781470 | Aminodicarboxylic acid derivatives having pharmaceutical properties The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, wherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for u... | 08/24/2010 |
| 7776922 | Substituted [(phenylethanoyl)amino]benzamides The invention relates to substituted [(phenylethanoyl)amino]benzamides and methods for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of inflammatory disorders such as, for example,... | 08/17/2010 |
| 7723347 | Substituted phenylamino-pyrimidines The invention relates to substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders. ... | 05/25/2010 |
| 7511067 | 3-hydroxymethyl-4-hydroxy-phenyl-derivatives for the treatment of respiratory diseases The present invention relates to the use of the compounds of general formula 1 wherein the groups R1, X and Y may have the meanings given in the claims and in the specification, for preparing a pharmaceutical com... | 03/31/2009 |
| 7371743 | Carboxylic acid amides, the preparation thereof and their use as medicaments The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers,... | 05/13/2008 |
| 7335473 | Causative agent of the Mystery Swine Disease, vaccine compositions and diagnostic kits Composition of matter comprising the causative agent of Mystery Swine Disease, Lelystad Agent, in a live, attenuated, dead, or recombinant form, or a part or component of it. Vaccine compositions and diagnostic kits based thereon. Recombinant nucleic acid comprising... | 02/26/2008 |
| 7321041 | 1,6 Naphthyridines useful as inhibitors of SYK kinase Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating disease... | 01/22/2008 |
| 7314187 | Atomizer for applying liquids onto eyes Atomizers for administering liquids to the cornea or conjunctiva of the eye, special eye adapters for atomizers and the use of atomizers for ophthalmological administration. The atomizers are free from propellant gas and have an energy reservoir for supplying the en... | 01/01/2008 |
| 7270838 | Composition for treating chronic venous insufficiencies using an extract of red vine leaves The invention relates to a dietary supplement consisting of an aqueous extract of red vine leaves and an acceptable carrier which prevents and reduces the discomfort relating to mild-to-moderate chronic venous insufficiency of the legs. ... | 09/18/2007 |
| 7256314 | Method for generating secondary phosphines This invention provides a method for generating secondary phosphines from secondary phosphine oxides in the presence of a reducing agent, such as diisobutylaluminum hydride (DIBAL-H), triisobutyldialuminoxane, triisobutylaluminum, tetraisobutyldialuminoxane, or anot... | 08/14/2007 |
| 7217711 | Piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutical compositions The present invention relates to substituted imidazo[4,5-d]pyridazin-4-ones of general formula wherein R1 to R3 and n are defined as in claims 1 to 8, the tautomers, enantiomer... | 05/15/2007 |
| 7122347 | Chimeric Arterivirus-like particles The invention relates to the field for Arteriviruses and vaccines directed against infections caused by these viruses. The invention provides an Arteriviruses-like particle comprising at least a first structural protein derived from a first Arterivirus and a second ... | 10/17/2006 |
| 7109192 | Substituted imidazo-pyridinones and imidazo-pyridazinones, the preparation thereof and their use as pharmaceutical compositions The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula wherein R1 to R4 are defined as in claim 1, the tautomers, the stereoisom... | 09/19/2006 |
| 7090093 | Pressure compensation device for a two-part container For medical fluids, two-part containers are used which consist of an inner container and an outer container which is impenetrable to diffusion. The inner container collapses when the fluid is removed. For the purposes of pressure compensation between the gaseous spa... | 08/15/2006 |
| 7084140 | Arylglycinamide derivatives, method of producing said derivatives and pharmaceutical compositions containing these compounds The invention relates to new arylglycinamide derivatives of general formula I and the pharmaceutically acceptable salts thereof, wherein R1 and R2 together with the N to which they are bound... | 08/01/2006 |
| 7043966 | Quality control systems for detecting leaks of gaseous or liquid materials from closed containers A system for testing systems which are in turn used to test the leaktightness of a hollow body is suggested. Instead of the hollow body, a test body (2) is placed in the system which generates a defined pressure increase in a measuring chamber (4 | 05/16/2006 |
| 7017391 | Method for measuring the leaktightness of sealed containers The present invention relates to a method for reliably and rapidly checking the leaktightness of sealed containers or their leakage rate by the action of a gas thereon. The method according to the invention is particularly suitable for checking the leaktightness of ... | 03/28/2006 |
| 7019021 | Compounds and methods for treating urinary incontinence Compounds of the formula (II) wherein R1, R2, R3, R4, and R5 are as set forth herein, pharmaceutical compositions containing them, and their use in treating urinary... | 03/28/2006 |
| 6998406 | Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments Fluorenecarboxylic acid esters of general formula 1 wherein X− and the groups A, R, R1, R2, R3, R3′, R4, and R4′ have the meanings given... | 02/14/2006 |
| 6991816 | Composition for treating chronic venous insufficiencies using an extract of red vine leaves The invention relates to a dietary supplement consisting of an aqueous extract of red vine leaves and an acceptable carrier which prevents and reduces the discomfort relating to mild-to-moderate chronic venous insufficiency of the legs. ... | 01/31/2006 |
| 6986346 | Closure-cap and container as a two-chamber cartridge for nebulisers for producing aerosols and active substance formulations, suitable for storage The invention relates to an apparatus comprising a closure-cap and a container in the form of a two-chamber cartridge in which an active ingredient and a solvent can be stored separately until the apparatus is used in a nebuliser, as well as an active substance conc... | 01/17/2006 |
| 6960581 | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof A compound of Formula (I) wherein R1, R2, R3, R4, R5, and R6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof, pharmaceutical com... | 11/01/2005 |
| 6945472 | Locking-stressing mechanism for a miniaturised high pressuriser A locking tensioning mechanism for a miniaturised high pressure generator is disclosed, which mechanism will allow delivery of a set volume of a liquid, and the volume to be delivered by a high pressure generator can be altered subsequently by adjusting one of the s... | 09/20/2005 |
