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...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Number | Title | Issue Date |
| 4870170 | Process for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics Process and intermediates for the conversion of 3R,4R-4-acetoxy-3-[1R-1-(silyloxy)ethyl]-2-acetidinones to antibacterial 5R,6S-6-(1R-1-hydroxyethyl)-2-(1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids, and the pharmaceutically-acceptable salts and pivalo... | 09/26/1989 |
| 4868296 | 6-(1-carbamoyl-1-hydroxymethyl) penicillanic acid derivatives 6-(1-Carbamoyl-1-hydroxymethyl)penicillanic acid derivatives are useful as antibacterials and/or beta-lactamase inhibitors.... | 09/19/1989 |
| 4868297 | Process for preparing sultamicillin and analogs 6-Halo- and 6,6-dihalo-1,1-dioxopenicillanoyloxymethyl 6-[D-2-(2-alkoxycarbonyl-1-methylvinylamino- and 1-methyl-3-oxo-1-butenylamino)-2-phenylacetamido]penicillanates and analogs; process for their conversion to sultamicillin and analogs; and proces... | 09/19/1989 |
| 4864046 | Process for optically active 3-thiolanyl sulfonate esters Intermediates and a stepwise process for the conversion of ethyl 4-chloro-3R-hydroxybutyrate to optically active compounds of the formula ##STR1## wherein R is (C1 -C3)alkyl, phenyl or tolyl. The later compounds are in turn usef... | 09/05/1989 |
| 4861880 | 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents Certain substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones are highly potent gabaergic agents, valuable in the treatment of individuals suffering from schizophrenia or reversing the side effects of a previously or concurrently administered neurol... | 08/29/1989 |
| 4859679 | Antiulcer (alkyldithio) quinoline derivatives Quaternary 8-(alkyldithio)-1-(2-pyrimidyl)-quinolinium salts, inhibitors of the H30 /K+ ATPase enzyme, are useful in the treatment of ulcers.... | 08/22/1989 |
| 4857641 | C.12 modified erythromycin A derivatives Antibacterial 12,12'-anhydro-9R-hydroxy-9-deoxoerythromycin A derivatives, intermediate therefor and process of 12,12'-dehydration.... | 08/15/1989 |
| 4853410 | Hydroxyacetic acid derivatives for the treatment of diabetic complications Racemic and chiral (2R,4R)-4-c-hydroxy-2-4-(substituted)chroman(and thiochroman)-4-acetic acids and their pharmaceutically acceptable salts, their use in the treatment of diabetic complications and intermediates therefor.... | 08/01/1989 |
| 4849518 | Quinazolin-4(3H)-one derivatives as anticoccidial agents Variously substituted trans-3-[3-(3-hydroxypiperid-2-yl)-2-oxopropyl]quinazoline-4(3H)-ones, a method of controlling or preventing coccidiosis in poultry therewith, intermediates therefor, and a process for the preparation of certain intermediates th... | 07/18/1989 |
| 4847245 | N-demethylefrotomycin N-Demethylefrotomycin, a valuable new antibiotic substance, is produced by the microbial conversion of mocimycin using a novel, efrotomycin-producing, microbial species ATCC 53758.... | 07/11/1989 |
| 4812455 | Antiinflammatory compositions and methods An improved antiinflammatory composition and method of treating inflammation which employs a combination of antiinflammatory piroxicam, or a pharmaceutically acceptable salt thereof, with analgesic acetaminophen, antidepressant doxepin, bronchodilator pir... | 03/14/1989 |
| 4812471 | Hypoglycemic 5-(isoxazolyl or isothiazolyl)-oxazolidine-2,4-diones Hypoglycemic 5-chromanyl, 2,3-dihydro-5-benzo[b]-furanyl, 5-pyridyl, 5-quinolyl, 5-pyrrolyl, 5-indolyl, 5-thiazolyl, 5-oxazolyl, 5-isothiazolyl and 5-isoxazolyl oxazolidine-2.4-diones and the pharmacetically-acceptable salts thereof; certain 3-acylated de... | 03/14/1989 |
| 4803076 | Controlled release device for an active substance A device for the controlled release of a substance having useful activity into a fluid medium at a substantially constant rate, said substance contained in a shape which is substantially that of a truncated cone by means of an impermeable wall or coating ... | 02/07/1989 |
| 4797486 | Heterocyclic ring fused pyrimidine-4(3H)-ones as anticoccidial agents Certain trans-3-[3-(3-hydroxy-2-piperidyl)-2-oxopropyl]thieno[3,2-d]pyrimidin-4(3H )-one and furo[3,2-d]pyrimidin-4(3H)-one derivatives, a method of using same as anticoccidial agents, intermediates therefor, and a process for certain intermediates th... | 01/10/1989 |
| 4797394 | 6-(1-carbamoyl-1-hydroxymethyl)penicillanic acid derivatives 6-(1-Carbamoyl-1-hydroxymethyl)penicillanic acid derivatives are useful as antibacterials and/or beta-lactamase inhibitors.... | 01/10/1989 |
| 4794179 | 2-(1-oxo-3-thiolanyl)-2-penem antibiotics Process and intermediates for the conversion of 3R,4R-4-acetoxy-3-[1R-1-(silyloxy)ethyl]-2-azetidinones to antibacterial 5R,6S-6-(1R-1-hydroxyethyl)-2-(1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids, and the pharmaceutically-acceptable salts and pivalo... | 12/27/1988 |
| 4782165 | Process for biotin intermediates In the synthesis of biotin and decarboxybiotin, a more direct method for the conversion of 1,3-diacyl-4-(bromomethyl)-5-[(5-alkoxycarbonylpentanoyl) or hexanoyl]-4-imidazolin-2-ones to 1,3-diacyl-4-[(4-alkoxybutanoyl) or pentanoyl]-1H,3H-thieno (3,4-... | 11/01/1988 |
| 4782146 | Process for the synthesis of penems A process for the synthesis of penems from azetidinones via 1-aza-4,5-dithiabicyclo[4.2.0]oct-2-en-8-one-2-carboxylate esters.... | 11/01/1988 |
| 4782145 | Process for penem derivatives An efficient process for converting readily available 4-acetoxy-2-azetidinones to allyl 2-thioxopenam-3-carboxylates, intermediates useful for the synthesis of penem antibiotics.... | 11/01/1988 |
| 4769232 | Parenteral formulations of indolmycin Solutions of indolmycin in a pharmaceutically-acceptable solvent are of special value in the treatment of susceptible bacterial infections in mammals, particularly swine.... | 09/06/1988 |
| 4766117 | Antiinflammatory compositions and methods An improved antiinflammatory composition and method of treating inflammation which employs a combination of antiinflammatory piroxicam, or a pharmaceutically acceptable salt thereof, with analgesic acetaminophen, antidepressant doxepin, bronchodilator pir... | 08/23/1988 |
| 4762838 | Quinazolin-4(3H)-one derivatives as anticoccidial agents Variously substituted trans-3-[3-(3-hydroxypiperid-2-yl)-2-oxopropyl]quinazolin-4-(3H)-ones, a method of controlling or preventing coccidiosis in poultry therewith, intermediates therefor, and a process for the preparation of certain intermediates th... | 08/09/1988 |
| 4762921 | 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives 6-(1-Acyl-1-hydroxymethyl)penicillanic acid derivatives are useful as antibacterials and/or beta-lactamase inhibitors.... | 08/09/1988 |
| 4761485 | Synthetic method for indol-2(3H)-ones A two-step process for the synthesis of certain indol-2(3H)-ones from indoles, and the 3,3-dibromoindol-2(3H)-ones which are intermediates in that process.... | 08/02/1988 |
| 4753956 | Hypoglycemic 5-substituted oxazolidine-2,4-diones Hypoglycemic 5-chromanyl, 2,3-dihydro-5-benzo[b]-furanyl, 5-pyridyl, 5-quinolyl, 5-pyrrolyl, 5-indolyl, 5-thiazolyl, 5-oxazolyl, 5-isothiazolyl and 5-isoxazolyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated d... | 06/28/1988 |
| 4751297 | Method for preparation of azetidinone-1-oxoacetate by oxidation of the corresponding 2-hydroxyacetate A process for production of a 2-azetidinone-1-oxoacetate of the formula ##STR1## useful as an intermediate for preparation of 2-SR2 -substituted-2-penem-3-carboxylate andtibacterial agents; R is a conventional hydroxy protecting group, R1 | 06/14/1988 |
| 4743632 | Polyetherurethane urea polymers as space filling tissue adhesives Purified diisocyanate polyetherurethane prepolymers and process therefor. Polyetherurethane urea polymers prepared by mixing said prepolymers with an aqueous solution of an amino, ureido or hydroxy substituted amine or a like-substituted alpha-amino acid,... | 05/10/1988 |
| 4738972 | Hypoglycemic thiazolidinediones Hypoglycemic 5-[1-(5,6,7,8-tetrahydro-2-napthyl-; 1,2,3,4-tetrahydro-6-quinolyl-; 2-indanyl-; and 2-indolyl)alkyl]thiazolidine-2,4-dione derivatives, pharmaceutically acceptable salts thereof, and a method for their use in the treatment of hyperglyce... | 04/19/1988 |
| 4739047 | Intermediates for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics Process and intermediates for the conversion of 3R,4R-4-acetoxy-3-[1R-1-(silyloxy)ethyl]-2-azetidinones to antibacterial 5R,6S-6-(1R-1-hydroxyethyl)-2-(1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids, and the pharmaceutically-acceptable salts and pivalo... | 04/19/1988 |
| 4732907 | Antiprotozoal diamidines and bis-imidazoline Diamidines of the formula ##STR1## wherein X is a propylene, isobutylene, guanidine, pyrrole, tetrazole, imidazole or substituted imidazole group; and 2-[4-(2-imidazolinyl)phenyl]-6-(2-imidazolinyl)indole, are useful in the treatment of certain ... | 03/22/1988 |
| 4729985 | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues A series of novel polypeptide derivatives, containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues, which are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Particularly valuable precursors for many of these c... | 03/08/1988 |
| 4727159 | Triazoles Antifungal 1-[3-(substituted)-2-hydroxy-2-(perfluoroalkyl)-propyl]triazole derivatives wherein the 3-propyl substituent represents optionally substituted phenoxy, heteroaryloxy, alkylthio, alkylsulfinyl, alkylsulfonyl or optionally substituted carbamoyl.... | 02/23/1988 |
| 4725599 | Heterocyclic ring fused pyrimidine-4 (3H)-ones as anticoccidial agents Certain trans-3-[3-(3-hydroxy-2-piperidyl)-2-oxopropyl]thieno[3,2-d]pyrimidin-4(3H )-one and furo[3,2-d]pyrimidin-4(3H)-one derivatives, a method of using same as anticoccidial agents, intermediates therefor, and a process for certain intermediates th... | 02/16/1988 |
| 4709044 | Biotin intermediates In the synthesis of biotin and decarboxybiotin, a more direct method for the conversion of 1,3-diacyl-4-(bromomethyl)-5-[(5-alkoxycarbonylpentanoyl) or hexanoyl]-4-imidazolin-2-ones to 1,3-diacyl-4-[(4-alkoxybutanoyl) or pentanoyl]-1H,3H-thieno(3,4-b... | 11/24/1987 |
| 4704456 | Process for sultamicillin intermediate An improved process for the preparation of the chloromethyl ester of sulbactam (chloromethyl penicillanate 1,1-dioxide), an intermediate in the synthesis of sultamicillin (the mixed methanediol ester of sulbactam and ampicillin).... | 11/03/1987 |
| 4704461 | Processes and intermediates for sorbinil Chiral sorbinil intermediates of the formula ##STR1## wherein R is hydrogen or benzyloxycarbonyl and Y is hydroxy or amino, processes therefor, and processes for the conversion thereof to sorbinil.... | 11/03/1987 |
| 4703052 | Hypoglycemic thiazolidinediones Hypoglycemic 2,3-dihydro-5-benzo[b]furanyl-2,3-dihydro-5-benzo[b]thienyl-, 3,4-dihydro(2H)-6-benzopyranyl- and 6-thiochromanyl-thiazolidine-2,4-diones and pharmaceutically acceptable salts thereof, method for their use in treatment of hyperglycemic animal... | 10/27/1987 |
| 4698444 | 1,1-bis(p-fluorophenyl)urea 1,1-Di(p-fluorophenyl)urea, 2-carbobenzoxy-8-fluoro-5-(p-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4, 3-b]indole, an efficient process for converting the former to the latter, further comprising conversion of the latter to 8-fluoro-5-(p-fluorophenyl)... | 10/06/1987 |
| 4695626 | 1-aza-4,5-dithiabicyclo [4.2.0] oct-2-en-8-one-2 carboxylate esters 1-aza-4,5-dithiabicyclo [4.2.0] oct-2-en-8-one-2 carboxylate ester intermediates useful for the synthesis of penems.... | 09/22/1987 |
| 4695634 | Hypoglycemic 5-substituted oxazolidine-2,4-diones Hypoglycemic 5-furyl and 5-thienyl derivatives of oxazolidine-2,4-dione and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; and intermediates useful in the preparation of said compounds.... | 09/22/1987 |
