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| Number | Title | Issue Date |
| 6942965 | Hepatitis A virus nucleotide sequences, recombinant proteins and uses thereof Hepatitis A virus primers and probes derived from the capsid proteins and junction between the capsid precursor P1 and 2A of the HAV genome are disclosed. Also disclosed are nucleic acid-based assays using the primers and probes, antigen detection of HAV, and immuno... | 09/13/2005 |
| 6939849 | Recombinant PDGF A-chain homodimers and methods of use DNA encoding two forms of PDGF A-chain polypeptide, the construction of expression vectors for expressing such DNA in yeast and mammalian cells, and the expression of such DNA in yeast and mammalian cells to produce active PDGF A-chain homodimer and active PDGF A-ch... | 09/06/2005 |
| 6914131 | Neisserial antigens The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens ... | 07/05/2005 |
| 6884435 | Microparticles with adsorbent surfaces, methods of making same, and uses thereof The present invention is directed to microparticles, to microparticle compositions containing the same, to methods of forming the same, and to uses for the same, including use for a vaccine, for raising an immune response, for treatment of a disease and for diagnosi... | 04/26/2005 |
| 6863896 | Plant lectins as mucosal adjuvants The invention provides a method of increasing an immune response in a mammal. The method involves administering to the mammal an admixture comprising an immunogen and a plant lectin. The plant lectin acts as an adjuvant to increase an immune response against the imm... | 03/08/2005 |
| 6861410 | Immunological adjuvant compositions The present invention is directed to novel adjuvant compositions, which target the cellular and/or humoral arms of immunity. According to an embodiment of the invention, an oil-in-water adjuvant composition is provided that comprises: (a) water; (b) a metabolizable ... | 03/01/2005 |
| 6861212 | NANBV diagnostics and vaccines A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBH), but which are absent from individuals infected with h... | 03/01/2005 |
| 6855321 | Polyepitope carrier protein The invention relates to polyepitope carrier proteins that comprise at least five CD4+ T cell epitopes, for conjugation to capsular polysaccharides. The carrier proteins are use useful as components of vaccines that can elicit a T-cell dependent immune response. The... | 02/15/2005 |
| 6855492 | Use of microparticles combined with submicron oil-in-water emulsions Compositions are provided which include biodegradable microparticles with entrapped or adsorbed antigens, in combination with submicron oil-in-water emulsions. Also provided are methods of immunization which comprise administering to a vertebrate subject (a) a submi... | 02/15/2005 |
| 6846921 | Chimeric antisense oligonucleotides and cell transfecting formulations thereof Chimeric oligonucleotide of the formula 5′-W—X1—Y—X2—Z-3′, where W represents a 5′-O-alkyl nucleotide, each of X1 and X2 represents a block of seven to twelve phosphodiester-linked 2′-O-alkyl ribonucleotide... | 01/25/2005 |
| 6844168 | Compositions comprising polynucleotides encoding human fibroblast growth factor receptor and uses thereof A new receptor for fibroblast growth factor has been cloned and expressed. The recombinant receptor is useful for inhibiting FGF activity, and for screening compounds for binding activity similar to that of FGF. A soluble, truncated recombinant receptor is also prep... | 01/18/2005 |
| 6841155 | Immunization against and treatment for infection by H. pylori Methods for treating and/or protecting H. pylori infection are described. The methods utilize non-mucosal administration of an effective amount of one or more H. pylori antigens. ... | 01/11/2005 |
| 6830906 | Manganese superoxide dismutase cloning and expression in microoganisms Methods and compositions are provided for the production of human manganese superoxide dismutase and a protocol for enhancing efficiency of expression. The gene encoding for human manganese superoxide dismutase was isolated and inserted into a vector in conjunction ... | 12/14/2004 |
| 6825333 | EGFH2 genes and gene products This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins. ... | 11/30/2004 |
| 6824793 | Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants Compositions are provided which include hyaluronic acid derivatives in combination with vaccine antigens, and optionally adjuvants, for mucosal delivery. Also provided are methods of making the compositions, as well as methods of immunization using the same. ... | 11/30/2004 |
| 6818439 | Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders Methods are provided for obtaining measurable levels of a protein, nucleic acid molecule, or enzymatic product in a bodily fluid or cells of a human, comprising the step of administering to a human a recombinant retroviral preparation having a titer on HT1080 cells ... | 11/16/2004 |
| 6818222 | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E. coli (LT). ... | 11/16/2004 |
| 6815160 | Hepatitis C viral antigen immunoassay detection systems Imnunoassays for detecting hepatitis C virus protein and immune complexes between hepatitis C virus protein and antibodies in biological samples, methods of screening blood products for hepatitis C virus, and kits employed therefor are provided. ... | 11/09/2004 |
| 6809194 | Akt3 inhibitors Inhibitors of human Akt3, including antisense oligonucleotides, methods, and compositions specific for human Akt3, are provided. Methods of using the compositions for modulating Akt3 expression and for regulating cell growth, particularly tumor cell growth, are also... | 10/26/2004 |
| 6806360 | Nucleic acids encoding human tissue factor inhibitor A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined. ... | 10/19/2004 |
| 6800760 | Quinolinone derivatives Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and... | 10/05/2004 |
| 6800632 | Bicyclic inhibitors of glycogen synthase kinase 3 New bicyclic based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed a... | 10/05/2004 |
| 6797809 | Multiple fusion antigens for use in immunoassays for anti-HCV antibodies HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays. ... | 09/28/2004 |
| 6797695 | Human FGF-20 gene and gene expression products This invention relates to human fibroblast growth factor (hFGF-20), and to variants thereof and to polynucleotides encoding FGF-20. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and anti... | 09/28/2004 |
| 6783960 | Chimeric proteins Chimeric proteins possessing Kunitz-type domain 1 of TFPI-2 and Kunitz-type domain 2 of TFPI are disclosed, as are muteins of TFPI and TFPI-2. Nucleic acid sequences, expression vectors and transformed host cells encoding and capable of producing the disclosed chime... | 08/31/2004 |
| 6783929 | Biological sample component purification and differential display Provided are affinity support materials having intermediate binding affinity for biological samples. Among the materials provided by the present invention are hydrophilic solid supports composed of hydrophilic ligands coupled to hydrophilic matrixes which are compat... | 08/31/2004 |
| 6777538 | Binding protein A 24 kd protein capable of binding the E2 envelope protein of hepatitis C virus (HCV), and functionally equivalent variants or fragments of the 24 kd protein, are disclosed. Processes for production and purification of the 24 kd protein, and functionally equivalent ... | 08/17/2004 |
| 6774237 | Quinolinone derivatives Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and... | 08/10/2004 |
| 6767699 | Method for the quantitation of alphavirus replicon particles Methods of production and purification for viruses and virus-derived vectors, including those related to alphaviruses, are disclosed. In one aspect, methods of purification that subject alphavirus replicon particle preparations to one or more steps of chromatographi... | 07/27/2004 |
| 6762194 | Quinolinone derivatives Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and... | 07/13/2004 |
| 6759417 | Heterocyclic compounds Organic compounds having the structural formulas I, II, and III are provided where the variables have the values described herein and R1 and R2 in structure I join together to form a 5 to 7 membered substituted or unsubstituted ring including a... | 07/06/2004 |
| 6756359 | C12 modified erythromycin macrolides and ketolides having antibacterial activity Antimicrobial macrolide compounds are provided having formulas II: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bact... | 06/29/2004 |
| 6756383 | Heterocyclic derivatives of quinolinone benimidazoles Organi c compounds having the structural formulas I, II, and III are provided where the variables have the values described herein and R1 and R2 in structure I join together to form a 5 to 7 membered substituted or unsubstituted ring including ... | 06/29/2004 |
| 6753015 | Microparticle compositions and methods for the manufacture thereof Microparticles with adsorbed complexes of macromolecule and detergent, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a p... | 06/22/2004 |
| 6743602 | Polynucleotides differentially expressed in adenocarcinomas, polypeptides encoded thereby, and methods of use thereof The present invention features human HX2004-6 polypeptide and nucleotide sequences encoding HX2004-6 polypeptides. In a particular aspect, the polynucleotide is the nucleotide sequence of SEQ ID NO:1. In related aspects the invention features expression vectors and ... | 06/01/2004 |
| 6740323 | HBV/HCV virus-like particle Chimeric antigens derived from hepatitis B virus (HBV) and hepatitis C virus (HCV) are described which form virus-like particles when co-expressed with an excess of hepatitis B virus surface antigen (HBsAg). The chimeric antigens are fusion proteins containing an im... | 05/25/2004 |
| 6737233 | Method for preparing HCV E2 binding protein A 24 kd percent capable of binding the E2 envelope protein of hepatitis C virus (HCV), and functionally equivalent variants or fragments of the 24 kd protein, are disclosed. Processes for production and purication of the 24 kd protein, and functionally equivalent va... | 05/18/2004 |
| 6730297 | Use of recombinant gene delivery vectors for treating or preventing lysosomal storage disorders Gene delivery vectors, for example, recombinant FIV vectors, and methods of using such vectors are provided for use in treating or preventing retinal diseases of the eye and diseases of the brain associated with lysosomal storage disorders. ... | 05/04/2004 |
| 6727273 | Estrogen receptor modulators Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating es... | 04/27/2004 |
| 6716624 | GSK3 polypeptides The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino... | 04/06/2004 |
