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| Number | Title | Issue Date |
| 7255877 | Fenofibrate microparticles Fenofibrate microparticles are prepared using a combination of surface modifiers with a phospholipid. Particle size growth and stability are controlled while significantly smaller sized fenofibrate particles are produced. ... | 08/14/2007 |
| 7220402 | Alpha-fetoprotein peptides and uses for imaging The invention provides diagnostic procedures wherein the presence or absence of a cell-proliferating disorder, e.g., a breast cancer, may be determined. The imaging agents of the invention include alpha-fetoprotein hydrophilic analogs which have been determined to t... | 05/22/2007 |
| 7186401 | Dry powder for inhalation The aim of the invention is to improve the moisture resistance of dry powder formulations for inhalation which contain a pharmaceutically ineffective carrier of not-inhalable particle size and a finely divided pharmaceutically active compound of inhalable particle s... | 03/06/2007 |
| 7183064 | Method for identifying pre-neoplastic and/or neoplastic states in mammals The present invention relates to methods of identifying pre-neoplastic and/or neoplastic states in mammals and in particular to a method for identifying pre-neoplastic and neoplastic cells in tissues and body fluids, based on differential expression of purinergic re... | 02/27/2007 |
| 7132400 | Alpha-fetoprotein peptides and uses thereof The subject invention addresses the need for methods of treatment and prevention of breast cancer, and other cancers, by providing a peptide of eight to twenty amino acids in length which comprises a hydrophilic analog of an alpha-fetoprotein peptide having SEQ ID N... | 11/07/2006 |
| 7122522 | Alpha-fetoprotein peptides and uses thereof Therapeutic compounds which are cell proliferation modulators, preferably inhibitors. These modulators contain amino acid structures that are arranged as a hydrophilic analog of an alpha-fetoprotein. The modulator may be a peptide itself, e.g., an octapeptide like t... | 10/17/2006 |
| 7119195 | Pharmaceutically acceptable starch Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, dissolving the starch in aqueous medium, molecular weight reduction by shearing, an... | 10/10/2006 |
| 7091240 | Tubulin binding ligands and corresponding prodrug constructs A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin... | 08/15/2006 |
| 7070944 | System for screening fatty acid transport inhibitors, methods of use and modulators identified thereby Methods for identifying modulators of fatty acid transport and/or uptake, comprising contacting, under conditions favorable for fatty acid uptake, a putative modulator, e.g., an inhibitor with a system comprising genetic material encoding a fatty acid transport medi... | 07/04/2006 |
| 7056885 | Fibroblast growth factor and nucleic acids encoding same The present invention provides FGF-CX polypeptides and polynucleotides, and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides m... | 06/06/2006 |
| 7037906 | Methods for modulating tumor growth and metastasis Methods and pharmaceutical compositions for modulating tumor growth or metastasis are provided. ... | 05/02/2006 |
| 7034132 | Therapeutic polypeptides, nucleic acids encoding same, and methods of use Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives... | 04/25/2006 |
| 6919324 | Functionalized stilbene derivatives as improved vascular targeting agents Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubul... | 07/19/2005 |
| 6916907 | Nucleic acids encoding osteoprotegern-like proteins and methods of using same Disclosed are osteoprotegerin-like polypeptides, nucleic acids encoding osteoprotegerin-like polypeptides, and methods of using these molecules. The osteoprotegerin-like polypeptides sequence homology to osteoprotegerin and tumor necrosis factor receptor molecules. | 07/12/2005 |
| 6911308 | Methods for detecting, grading or monitoring an H. pylori infection The present invention provides methods for determining the status of an H. pylori infection by detecting a high-integrity H. pylori nucleic acid in a patient sample. ... | 06/28/2005 |
| 6863889 | Polynucleotides and proteins encoded thereby The present invention provides novel isolated SECX polynucleotides and the membrane-associated or selected polypeptides encoded by the SECX polynucleotides. Also provided are the antibodies that immunospecifically bind to a SECX polypeptide or any derivative, varian... | 03/08/2005 |
| 6855702 | Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a r... | 02/15/2005 |
| 6855806 | Thymosin beta 10-like proteins and nucleic acids encoding same Disclosed herein are novel human nucleic acid sequences. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforemen... | 02/15/2005 |
| 6852845 | Method of identifying toxic agents using NSAID-induced differential gene expression in liver The invention provides methods of identifying toxic agents, e.g., hepatotoxic agents, using differential gene expression. Also provided are methods of predicting the risk level and or injury type of NSAIDs. Also disclosed are novel nucleic acid sequences whose expre... | 02/08/2005 |
| 6844155 | Methods for detecting contamination in molecular diagnostics using PCR The invention provides methods for detecting contamination in a PCR reaction. Methods of the invention are especially useful for detection of contamination in heterogeneous samples containing a rare nucleic acid to be detected. ... | 01/18/2005 |
| 6818404 | Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples The invention provides amplification-based methods for detecting hypermethylated nucleic acid in heterogeneous biological samples, e.g., stool. A screening procedure based on the detection of hypermethylation, preferably at multiple genes, provides a means for detec... | 11/16/2004 |
| 6818741 | Alpha-fetoprotein peptides and uses therof The subject invention addresses the need for methods of treatment and prevention of breast cancer, and other cancers, by providing a peptide of eight to twenty amino acids in length which comprises a hydrophilic analog of an alpha-fetoprotein peptide having SEQ ID N... | 11/16/2004 |
| 6777388 | Leptin-related peptides The present invention relates to methods and compositions containing novel leptin peptides, preferably for the modulation of body mass (i.e., weight), more specifically for novel diagnostic and therapeutic applications in homeostasis of body weight and adipose tissu... | 08/17/2004 |
| 6773702 | Use of combretastatin A4 and its prodrugs as an immune enhancing therapy A method of treating immune suppression in a warm-blooded animal bearing a tumor, by administering to the animal an amount of combretastatin A4 and/or a prodrug thereof effective to enhance immune responsiveness without causing vascular destruction. Immunotherapy tr... | 08/10/2004 |
| 6670344 | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable prod... | 12/30/2003 |
