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Attorney: Bigley; Francis P., Daniel; Mark R., DiPrima; Joseph F.


Number of patents: 12
Last date: November 14, 1995

NumberTitleIssue Date
5466811Dioxolenylmethyl carbamates pro moieties for amine drugs
This invention relates to a the use of new oxodioxolenylmethyl carbamates to produce bioreversible neutral prodrugs from primary and secondary amines....
11/14/1995
5464762Asymmetric bioreduction of 6-bromo-2-tetralone to (s)-6-bromo-2 tetraol by trichosporon capitatum
Stereospecific (S)-6-bromo-2-tetraol is a key intermediate in the chemical synthesis of the chiral drug candidate, MK499, a ventricular arrythmias suppressant. The yeast strain Trichosporon capitatum (MY 1890) was employed for the bioconversion of 6-bromo...
11/07/1995
5439914Spirocycles
Compounds of the general structural formula: ##STR1## or a pharmaceutically acceptable salt, hydrate or crystal form thereof, wherein; X is O or CH2 R1 is H if R2 is not H or if R2 is H then R1 is ...
08/08/1995
5428031Methods of treating cardiac arrhythmia
Benzodiazepine analogs have been found to be useful in treating cardiac abnormalities....
06/27/1995
5426185Antiarrhythmic benzodiazepines
Benzo-(1,5)-diazepine derivatives with an amide or urea function in the 3-position are useful in the treatment of arrhythmia. The compounds have structural formulae: ##STR1##...
06/20/1995
5403846Spirocycles
Compounds of the general formula: ##STR1## or a pharmaceutically acceptable salt, hydrate or crystal form enantiomer, diastereomer or mixtures thereof are Class III antiarrhythmic agents....
04/04/1995
5399587Biologically active compounds
The present invention relates to novel potassium channel agonists which are useful in activating the calcium activated Maxi-K potassium channel in mammalian neuronal and smooth muscle tissue. The claimed compounds are of the general formula: ##STR1##...
03/21/1995
5382587Spirocycles
Spirocycles of the general structural formulae: ##STR1## wherein: X is O, CH2 or SOm ; R1 is AlkylSO2 NH--, AlkylO--, AlkylSO2 --, AlkylCONH--, or NO2 --; R2 is --H, --OAlkyl, or...
01/17/1995
5378838Benzodiazepine cholecystokinin antagonists
Benzodiazepine analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK)....
01/03/1995
5366738Controlled release drug dispersion delivery device
A device for the controlled delivery of a beneficial agent as a gelatinous dispersion consisting of (i) a core which contains a beneficial agent, a polymer which forms gelatinous microscopic particles upon hydration and if desired an agent to modulate the...
11/22/1994
5350584Spheronization process using charged resins
The invention comprises a novel process for the spheronization of charged resins. Spherical multiparticlates are produced which range in size from 0.3 mm to 3 mm in diameter. The spherical particle product is microcrystalline-free. The process consists of...
09/27/1994
5254345Poly(orthocarbonate acetal) bioerodible polymers
Polymers obtained by condensing polyols with divinyl orthocarbonates are useful for making bioerodible polymers for sustained release of beneficial agents....
10/19/1993
 
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