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| Number | Title | Issue Date |
| 8178620 | Surface modifying macromolecules with high degradation temperatures and uses thereof The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polyme... | 05/15/2012 |
| 8163696 | Treatment of inflammatory bowel disease using glucagon-like-peptide-2 (GLP-2) analogues GLP-2 analogues are disclosed which comprise one of more substitutions as compared to [hGly2]GLP-2 and which improved biological activity in vivo and/or improved chemical stability, e.g., as assessed in in vitro stability assays. More particularly, preferred GLP-2 a... | 04/24/2012 |
| 8163511 | Methods for the identification of LRRK2 interacting molecules The invention features methods for the identification of leucine-rich kinase 2 (LRRK2) inhibitors using indol ligand 91. Generally, these methods include identifying compounds that compete with indol ligand 91 for binding to LRRK2. ... | 04/24/2012 |
| 8158357 | Compositions and method for storage of nucleic acid from bodily fluids An aqueous composition comprising a denaturing agent, a chelator, a buffering agent and a protease for the extraction of nucleic acid from a sample of bodily fluid, such as saliva, such that the extracted nucleic acid is stable for at least fourteen days at room tem... | 04/17/2012 |
| 8153389 | Methods for the identification of PI3K interacting molecules and for the purification of PI3K The present invention relates to methods for the identification of a PI3K interacting compound using phenylthiazole ligand 1. ... | 04/10/2012 |
| 8143300 | Inhibitors of cellular necrosis The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly u... | 03/27/2012 |
| 8138314 | Compositions and methods of monoclonal and polyclonal antibodies specific for T cell subpopulations The invention provides compounds and methods for the ex vivo or in vivo expansion of NK T cells, CD1d-reactive T cells, and JαQ+ T cells, and the modulation of their activities. These compounds and methods have diagnostic and therapeutic applications. | 03/20/2012 |
| 8133490 | Method and system to remove cytokine inhibitors in patients A method to treat cancer uses ultrapheresis, refined to remove compounds of less than 120,000 daltons molecular weight, followed by administration of replacement fluid, to stimulate the patient's immune system to attack solid tumors. In the preferred embodiment, the... | 03/13/2012 |
| 8129131 | Pin1 as a marker for abnormal cell growth Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In one embodiment, the method includes detecting a level of Pin1 to stage an abnormal cell growth, such as breast or prostate cancer. In another embodiment, the method includes evaluating... | 03/06/2012 |
| 8123948 | Biomimetic water membrane comprising aquaporins used in the production of salinity power The present invention provides methods for producing salinity power using pressure retarded osmosis and a biometric membrane (e.g., a liquid bilayer membrane or a lipid membrane containing multiple bilayers of fused deposited lipid vesicles) containing aquaporin wat... | 02/28/2012 |
| 8110213 | Method of forming a tissue structure by introducing cells into an implanted matrix Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the ma... | 02/07/2012 |
| 8088567 | Human immortalised neural precursor cell line The present invention relates to an immortalized human neural precursor cell line, NGC-407. The cell line has been established from human foetal tissue. The cell line has been immortalized using a retroviral vector containing the v-myc oncogene. The cell line is a n... | 01/03/2012 |
| 8084020 | Use of anti-CD1 antibodies for the modulation of immune responses The invention provides methods for the administration of an anti-CD 1 antibody for the treatment or prevention of a variety of disorders, such as autoimmune disease, viral infection, bacterial infection, parasitic infection, infection by a eukaryotic pathogen, aller... | 12/27/2011 |
| 8078279 | Intravascular medical device An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secure... | 12/13/2011 |
| 8071683 | Surface modifying macromolecules with high degradation temperatures and uses thereof The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polyme... | 12/06/2011 |
| 8067236 | Optimized human T1R3 nucleic acid molecule The present invention relates to a screening system for modulators of GPCRs. Further it relates to recombinant vector systems for the heterologous expression of heterodimeric g-protein coupled receptors (GPCRs) in eukaryotic host cells. Preferably the functional exp... | 11/29/2011 |
| 8067235 | Optimized human T1R2 nucleic acid molecule The present invention relates to a screening system for modulators of GPCRs. Further it relates to recombinant vector systems for the heterologous expression of heterodimeric g-protein coupled receptors (GPCRs) in eukaryotic host cells. Preferably the functional exp... | 11/29/2011 |
| 8048998 | Mediated cellular delivery of LNA oligonucleotides The present invention relates to novel modified oligomeric compounds and to methods of making and using such compounds. The invention further relates to methods of enhancing the cellular uptake of oligomeric compounds comprising conjugating a metal chelator to those... | 11/01/2011 |
| 8026272 | Modified lysine-mimetic compounds Lysine mimetic compounds having useful pharmacological activity such as antiarrhythmic activity and desirable bioavailability properties are disclosed. ... | 09/27/2011 |
| 7994122 | Glucagon analogues The invention provides materials and methods for promoting weight loss or preventing weight gain in a subject. In particular, the invention provides novel glucagon analogue peptides effective in such methods and in the treatment of obesity, eating disorders, metabol... | 08/09/2011 |
| 7981915 | Methods for modulating PPAR biological activity for the treatment of diseases caused by mutations in the CFTR gene This invention features methods for treating diseases associated with mutations in the CFTR gene by administering PPAR agonists, specifically PPARγ, PPARα, and PPARδ agonists, PPAR inducers, and/or antioxidants. Also disclosed are screening methods for identifyin... | 07/19/2011 |
| 7977279 | Differential phage capture proteomics Disclosed herein are methods for identifying, isolating and comparing proteins and other biomolecules differing between two complex biological samples using affinity chromatography and phage display techniques. ... | 07/12/2011 |
| 7960529 | Bone delivery conjugates and method of using same to target proteins to bone A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid seque... | 06/14/2011 |
| 7955805 | Nucleic acids and polypeptides useful for diagnosing complications of pregnancy Disclosed herein are methods for diagnosing or treating pregnancy related hypertensive disorders that include the use of a polypeptide or a nucleic acid encoding a polypeptide selected from the following: follistatin related protein, interleukin 8, inhibin A, VEGF-C... | 06/07/2011 |
| 7947454 | Methods and apparatus for characterizing polynucleotides Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure having a nanopore aperture and a molecular motor, e.g., a polymerase,... | 05/24/2011 |
| 7947449 | Methods of diagnosing pre-eclampsia or eclampsia Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the... | 05/24/2011 |
| 7935786 | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis The invention is directed to a pharmacologically active peptide conjugate having a reduced tendency towards enzymatic cleavage comprising a pharmacologically active peptide sequence (X) and a stabilising peptide sequence (Z) of 4-20 amino acid residues covalently bo... | 05/03/2011 |
| 7914579 | Tissue engineered tendons and ligaments Connective tissue, including neo-tendons and ligaments, has been constructed using biodegradable synthetic scaffolds seeded with tenocytes. The scaffolds are preferably formed from biodegradable fibers formed of a polymer such as polyglycolic acid-polylactic acid co... | 03/29/2011 |
| 7906483 | Method for treating transplant rejection Compositions and methods for treating transplant rejection in a mammalian transplant recipient are provided. The method involves administering a therapeutically effective amount of Serp-1, its analogs, and biologically active fragments thereof in combination with an... | 03/15/2011 |
| 7902156 | Aprotinin polypeptides for transporting a compound across the blood-brain barrier The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides derived from aprotinin and from aprotinin analogs as well as conjugates and pharmaceutical compositions comprising these polypeptides or con... | 03/08/2011 |
| 7901358 | High frequency array ultrasound system A system for acquiring an ultrasound signal comprises a signal processing unit adapted for acquiring a received ultrasound signal from an ultrasound transducer having a plurality of elements. The system is adapted to receive ultrasound signals having a frequency of ... | 03/08/2011 |
| 7884078 | CPG15 compounds as insulin receptor and insulin-like growth factor receptor agonists Disclosed herein are CPG15 and CPG15-2 compounds and inhibitors that act as agonists and antagonists of the insulin receptor and insulin-like growth factor receptors, and the use of such compositions for the treatment of insulin and insulin-like growth factor-relate... | 02/08/2011 |
| 7846738 | Study of polymer molecules and conformations with a nanopore The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., ... | 12/07/2010 |
| 7846433 | Methods of treating pre-eclampsia and eclampsia Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the... | 12/07/2010 |
| 7857978 | Membrane for filtering of water Disclosed are novel water membranes comprising lipid bilayers incorporating functional aqua-porins. The lipid bilayers are arranged in sandwich structures including hydrophilic or hydro-phobic support materials. Also disclosed are water purification devices/systems,... | 12/28/2010 |
| 7850959 | Methods and compositions for treating conditions involving abnormal angiogenesis The present invention features methods and compositions for preventing, reducing, or treating hypoxia and pathological disorders involving abnormal angiogenesis (e.g., conditions involving decreases or increases in blood flow, respectively). Where an increase in ang... | 12/14/2010 |
| 7830069 | Arrayed ultrasonic transducer An ultrasonic transducer comprises a stack having a first face, an opposed second face and a longitudinal axis extending therebetween. The stack comprises a plurality of layers, each layer having a top surface and an opposed bottom surface, wherein the plurality of ... | 11/09/2010 |
| 7808156 | Ultrasonic matching layer and transducer In one aspect, matching layers for an ultrasonic transducer stack having a matching layer comprising a matrix material loaded with a plurality of micron-sized and nano-sized particles. In another aspect, the matrix material is loaded with a plurality of heavy and li... | 10/05/2010 |
| 7798963 | Method for synchronization of breathing signal with the capture of ultrasound data A method for producing an ultrasound image comprises monitoring the subject's respiration cycle or waveform, acquiring ultrasound data from the subject, producing an ultrasound image from the received ultrasound data received during the time when the subject's motio... | 09/21/2010 |
| 7767787 | Substance for obtaining highly effective tumor medications as well as a process The invention relates to a substance and a process for obtaining anti-tumor agents. ... | 08/03/2010 |
