Berstein; David L. - US Patent Attorneys and Agents

Attorney: Berstein; David L.

Number of patents: 28
Last date: February 14, 2012

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Number	Title	Issue Date
8114874	Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use. In particular, the compounds include embodiments in ...	02/14/2012
8106191	Synthetic multimerizing agents New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains. The compounds are of the formula M-L-Q where M is a synthetic ligand for an FKBP protein. ...	01/31/2012
8058426	Phosphorus-containing compounds and uses thereof This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, �...	11/15/2011
7709020	Implantable device comprising phosphorus-containing macrolides This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, �...	05/04/2010
7432277	Phosphorus-containing macrocycles This invention concerns a new family of phosphorus-containing macrocycles containing various phosphonate- and phosphonate-containing moieties. ...	10/07/2008
7238679	Heterocycles and uses thereof Compounds of the following formula are disclosed: wherein RB is a substituted or unsubstituted aryl or heteroaryl moiety; at least one of RU and RL is a phosphorus-containing moie...	07/03/2007
7186826	Phosphorus-containing compounds and uses thereof This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA— in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may...	03/06/2007
7115589	Purine derivatives This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use. In these compounds, R	10/03/2006
7091213	Phosphorus-containing compounds and uses thereof This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may b...	08/15/2006
7019139	Quinolinones and uses thereof The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): in which RA, RB, RC, RD, R5, R7, R9...	03/28/2006
7009054	Quinolines and uses thereof This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use. ...	03/07/2006
6693189	Materials and method for treating or preventing pathogenic fungal infection This invention concerns derivatives of rapamycin and their antifungal uses. Also disclosed are materials and methods relevant to the identification of non-immunosuppressive anti-fungal rapamycin derivatives. Use of compounds, among others, of the formula ...	02/17/2004
6649595	Regulation of biological events using novel compounds Materials and methods are disclosed for regulation of biological events such as target gene transcription and growth, proliferation or differentiation of engineered cells....	11/18/2003
6576766	Signal transduction inhibitors, compositions containing them This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediate by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to p...	06/10/2003
6573295	Bicyclic signal transduction inhibitors, compositions containing them & uses thereof This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to ...	06/03/2003
6566073	Materials and methods involving conditional retention domains Materials and methods involving conditional retention domains (CRDs) are disclosed. Also disclosed are fusion proteins containing CRDs and cells expressing such fusion proteins. In addition, the invention provides novel methods for producing target protei...	05/20/2003
6506379	Intramuscular delivery of recombinant AAV This invention concerns new configurations for biological switches and provides new methods and materials useful for regulating biological events in animal cells. The invention involves recombinant DNA constructs comprising DNA sequences derived from sequ...	01/14/2003
6482852	Bicyclic signal transduction inhibitors, compositions containing them & uses thereof This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to ...	11/19/2002
6479653	Compositions and method for regulation of transcription The present invention relates to novel fusion proteins which activate transcription, to nucleic acid constructs encoding the proteins and their use in the genetic engineering of cells....	11/12/2002
6306649	Heterologous transcription factors This invention provides novel materials and methods involving the heterologous expression of transcription factors which are useful for effecting transcription of target genes in genetically engineered cells or organisms containing them. Target gene const...	10/23/2001
6303319	Cell based assay for identifying sh2-domain-specific signal transducer antagonist The present invention provides methods and compositions for identifying inhibitors of the interaction between phosphopeptide binding pairs, i.e., a protein domain having at least one phosphopeptide binding domain and the phosphorylated ligands that bind t...	10/16/2001
6258823	Materials and method for treating or preventing pathogenic fungal infection This invention concerns derivatives of rapamycin and their antifungal uses. Also disclosed are materials and methods relevant to the identification of non-immunosuppressive antifungal rapamycin derivatives....	07/10/2001
6207397	In vitro fluorescence polarization assay An in vitro assay method permits the identification of a test substance which inhibits the mutual association of two molecules. The method includes the steps of providing two components capable of mutual association, one of said components bearing a coval...	03/27/2001
6187757	Regulation of biological events using novel compounds Materials and methods are disclosed for regulation of biological events such as target gene transcription and growth, proliferation or differentiation of engineered cells....	02/13/2001
5939528	Crystalline FRAP complex The invention relates to the human protein FRAP, and in particular to the FKBP12-rapamycin binding domain thereof and to the ternary complex formed by the FRB domain, rapamycin and FKBP12. A new crystalline composition comprising the ternary complex, coor...	08/17/1999
5710129	Inhibitors of SH2-mediated processes This invention relates to compounds of formula: ##STR1## and pharmaceutically acceptable salts thereof, where A is H, R1, --CO--R1 or --CO--OR1 where R1 is a substituted or unsubstituted alkyl, heteroalkyl,...	01/20/1998
4835260	Erythropoietin composition A new improved glycoprotein having erythropoietin-type activity is disclosed. The substrate is characterized by amino acid sequence substantially identical to the amino acid sequence of native human erythropoietin wherein the methionine-54 is replaced wit...	05/30/1989
4677195	Method for the purification of erythropoietin and erythropoietin compositions A method for purifying erythropoietin is described. The method comprises treating partially purifying erythropoietin by reverse phase high performance liquid chromatography to obtain homogeneous erythropoietin having a molecular weight of about 34,000 dal...	06/30/1987

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Attorney: Berstein; David L.