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| Number | Title | Issue Date |
| 8178574 | Tosylate salt of trans-N-isobutyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-yl-methyl)-phenyl] cyclobut anecarboxamide The present invention is directed to the tosylate salt of trans-N-isobutyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)-phenyl]-cyclobutanecarboxamide Formula (I): to solvates (e.g., hydrates) thereof, to polymorphs there... | 05/15/2012 |
| 8158673 | Histamine-3 receptor antagonists This invention is directed to a compound of formula I, as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a process of preparation of a compoun... | 04/17/2012 |
| 8158592 | Immunostimulatory nucleic acid molecules Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atop... | 04/17/2012 |
| 8158156 | Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal ... | 04/17/2012 |
| 8153814 | Sulfonamide derivatives The present invention relates to compounds of the formula and pharmaceutically acceptable salts, solvates or tautomers thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions... | 04/10/2012 |
| 8153141 | Immunostimulatory G, U-containing oligoribonucleotides Compositions and methods relating to immunostimulatory RNA oligomers are provided. The immunostimulatory RNA molecules are believed to represent natural ligands of one or more Toll-like receptors, including Toll-like receptor 7 (TLR7) and Toll-like rec... | 04/10/2012 |
| 8148340 | Immunomodulatory oligonucleotides Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are... | 04/03/2012 |
| 8138188 | Melanocortin type 4 receptor agonist piperidinoylpyrrolidines The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) wherein the variables and substituents are as defined herein and especially to selective MCR4 agonist compounds, to their use in ... | 03/20/2012 |
| 8134023 | Preparation of pregabalin and related compounds Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed. ... | 03/13/2012 |
| 8134007 | Pyridine derivatives The present invention relates to compounds of the formula (I): and pharmaceutically acceptable salts thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such c... | 03/13/2012 |
| 8129351 | Immunostimulatory nucleic acid molecules Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atop... | 03/06/2012 |
| 8124639 | Bicyclic [3.1.0] heteroaryl amides as type 1 glycine transport inhibitors The present invention relates to a series of substituted bicyclic[3.1.0]heteroaryl amides of the Formula I, wherein A, Q, X, Y, Z and R1-R5 groups are defined as in the specification, that exhibit activity as glycine transport inhibitors, their... | 02/28/2012 |
| 8124610 | Sodium channel inhibitors Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted sulfonamides, compositions comprisin... | 02/28/2012 |
| 8114848 | Immunomodulatory oligonucleotides Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are... | 02/14/2012 |
| 8114419 | Nucleic acid compositions for stimulating immune responses The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity. ... | 02/14/2012 |
| 8097733 | Pyrazole derivatives as 5-LO-inhibitors The invention relates to compounds of formula (I) processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same. ... | 01/17/2012 |
| 8093400 | Compounds useful in therapy The present invention provides compounds of formula (I), or pharmaceutically acceptable derivatives thereof wherein the variables Z, Q, Ring A, V, X, Y and Y′ are as defined herein, and pharmaceutical compositions compris... | 01/10/2012 |
| 8088804 | N-hydroxyamide derivatives possessing antibacterial activity Described herein are N-hydroxyamide antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions compound of Formu... | 01/03/2012 |
| 8084488 | Forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid magnesium Novel forms of atorvastatin magnesium salt designated Form A, Form B, Form C, Form D, Form E, and Form F, pharmaceutical compositions containing such compounds, methods for their preparation and methods utilizing the compounds for treatment of hyperlipidemia, hyperc... | 12/27/2011 |
| 8058249 | Immunostimulatory nucleic acid molecules Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atop... | 11/15/2011 |
| 8008266 | Methods of treating cancer using immunostimulatory oligonucleotides Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful ... | 08/30/2011 |
| 7998492 | Methods and products related to treatment and prevention of hepatitis C virus infection The invention provides methods for identifying and treating subjects having hepatitis C infections. In some instances, the subjects are those that are non-responsive to non-CpG therapy. Preferably, the subjects are treated with C class CpG immunostimulatory nucleic ... | 08/16/2011 |
| 7956043 | 5′ CpG nucleic acids and methods of use The invention relates to a class of CpG immunostimulatory oligonucleotides containing a 5′TCG motif or a CG at or near the 5′ end that are useful for stimulating an immune response. ... | 06/07/2011 |
| 7935675 | Immunostimulatory nucleic acid molecules Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful ... | 05/03/2011 |
| 7888327 | Methods of using immunostimulatory nucleic acid molecules to treat allergic conditions Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atop... | 02/15/2011 |
| 7879810 | Immunostimulatory nucleic acid molecules Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atop... | 02/01/2011 |
| 7825097 | Nucleotide vector vaccine for immunization against hepatitis Nucleotide vector comprising at least one gene or one complementary DNA coding for at least a portion of a virus, and a promoter providing for the expression of such gene in muscle cells. The gene may be the S gene of the hepatitis B virus. A vaccine preparat... | 11/02/2010 |
| 7820825 | N-substituted-azacyclylamines as histamine-3 antagonists The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor. ... | 10/26/2010 |
| 7820379 | Process for high throughput screening of CpG-based immuno-agonist/antagonist The invention pertains to murine TLR9 and related TLR9s which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR9. The in... | 10/26/2010 |
| 7807803 | Nucleic acid compositions for stimulating immune responses The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity. ... | 10/05/2010 |
| 7807165 | Antibodies directed against amyloid-beta peptide and methods using same Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described. Methods of using antibodies directed agains... | 10/05/2010 |
| 7803825 | Aminoalkylazole derivatives as histamine-3 antagonists The present invention provides a compound of formula Ia: and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor. ... | 09/28/2010 |
| 7795235 | Semi-soft c-class immunostimulatory oligonucleotides The invention relates to specific C-Class semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. In particular the oligonucleotides are useful for treating allergy, such as allergic rhinitis and asthma, cancer and infect... | 09/14/2010 |
| 7776344 | Methods related to immunostimulatory nucleic acid-induced interferon Methods and compositions are provided for extending the clinical utility of IFN-α in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-α treatment and reduce IFN-... | 08/17/2010 |
| 7772269 | Pyrazole analogs The invention relates to the compounds of formula (I): or a pharmaceutically acceptable salt and solvate thereof, wherein R1 is F or H and to processes for the preparation of, intermediates used in the preparatio... | 08/10/2010 |
| 7772223 | Carboxamide derivatives as muscarinic receptor antagonists The invention relates to compounds of formula processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them. ... | 08/10/2010 |
| 7771748 | Pharmaceutical compositions of 5,7,14-triazatetracyclo[10.3.1.0.0]-hexadeca-2(11),3,5,7,9-pentaene The present invention is directed to controlled-release (CR) oral pharmaceutical dosage forms of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene, 1, and pharmaceutically acceptable salts thereof, and methods of using ... | 08/10/2010 |
| 7767715 | Sulfonamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 08/03/2010 |
| 7754892 | Processes for the preparation of N-(2-acetyl-4,6-dimethylphenyl)-3-{[(3,4 dimethyl-5-isoxazolyl)amino]sulfonyl}-2-thiophenecarboxamide Provided are processes for the preparation of N-(2-acetyl-4,6-dimethylphenyl)-3-{[(3,4 dimethyl-5-isoxazolyl)amino]sulfonyl}-2-thiophenecarboxamide, a compound useful for the treatment of endothelin-mediated disorders. ... | 07/13/2010 |
| 7745630 | Triazolyl piperidine arginine vasopressin receptor modulators Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: Z, O, A, V, Y and Y′ are as defined herein; are useful for treating dysmenorreah. ... | 06/29/2010 |
