Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Number | Title | Issue Date |
| 8163979 | Antifungal plant proteins and methods of their use DNA constructions that provide for production of potent antifungal proteins in transgenic plants and transformed yeast cells are described. Methods of using the DNA constructs to produce transgenic plants that inhibit growth of plant pathogenic fungi are also disclo... | 04/24/2012 |
| 8153760 | Rhinovirus vaccines The present invention relates generally to peptide vaccines. More specifically, the present invention relates to vaccines against rhinoviruses and other related and non-related pathogenic animal viruses. In addition, the present invention relates generally to method... | 04/10/2012 |
| 8138226 | Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety diso... | 03/20/2012 |
| 8138205 | Heteroarylalkoxy-substituted quinolone inhibitors of PDE4 The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators. | 03/20/2012 |
| 8124092 | Antibodies against H5N1 strains of influenza A virus Provided are human antibodies that can neutralize a H5N1 strain of influenza A virus. Also provided are antibodies that can neutralize a strain of influenza A virus in clade 2 of the H5 subtype, that can neutralize a H5N1 strain of influenza A virus and have a lambd... | 02/28/2012 |
| 8101633 | Preparation and utility of substituted imidazopyridine compounds with hypnotic effects The present disclosure is directed to modulators of GABAA receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of sleep disorders an... | 01/24/2012 |
| 8080566 | Carbazole inhibitors of histamine receptors for the treatment of disease The present invention relates to carbazole compounds, pharmaceutical compositions comprising them, and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular... | 12/20/2011 |
| 8080563 | Bicyclic heteroaryl inhibitors of PDE4 The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PD E4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators. | 12/20/2011 |
| 8071371 | Monoclonal antibody production by EBV transformation of B cells A method for producing a clone of an immortalized human B memory lymphocyte, comprising the step of transforming human B memory lymphocytes using Epstein Barr Virus (EBV) in the presence of a polyclonal B cell activator. The method is particularly useful in a method... | 12/06/2011 |
| 8071324 | Methods for diagnosing and treating kidney cancer Methods, reagents and kits for diagnosing and treating kidney cancer are disclosed. An immunoassay for detecting kidney cancer is based on the relative change of the CELSR1 protein in urine or blood compared with normal tissue. An immunohistochemical assay for detec... | 12/06/2011 |
| 8063227 | Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron a... | 11/22/2011 |
| 8010717 | Method and system for communication and collaboration between a patient and healthcare professional Methods and platforms for enhancing collaboration and communication between a patient and his healthcare team are described. A personal health record is created for a patient and maintained by a service provider. The health record is updated with self-monitored or r... | 08/30/2011 |
| 8003407 | Lateral flow system and assay The present invention relates to a lateral flow assay and system, including a test strip, for detection and quantification of analytes in samples, such as samples containing cells and fluid. In general, according to the present invention, a test strip for a lateral ... | 08/23/2011 |
| 7964558 | Therapeutic applications for C-peptide The present invention relates to administration of C-peptide in a once daily dose for use in the treatment of diabetes and diabetic complications. ... | 06/21/2011 |
| 7960570 | Small molecule inhibitors of rotamase enzyme activity This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamas... | 06/14/2011 |
| 7955791 | Prewetting lateral flow test strip A test strip and method for detecting an analyte present in a sample. The test strip comprising: a buffer addition zone to which a buffer may be added; an absorbent zone proximal to the buffer addition zone; one or more test zones distal to the buffer addition zone,... | 06/07/2011 |
| 7915253 | Sulfonyl-substituted bicyclic compounds as modulators of PPAR Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed. ... | 03/29/2011 |
| 7879914 | Methods for treating viral infections using polyamine analogs Methods for treating viral infections using polyamine analogs, including mitoguazone (MGBG), are provided. In these methods, polyamine analogs destroy macrophages that act as viral reservoirs, facilitating the destruction of the viruses that dwell within the macroph... | 02/01/2011 |
| 7872013 | Preparation and utility of opioid analgesics The present disclosure is directed to modulators of opiate- and/or NMDA receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the use of such compounds for the treatment and/or management of pain, anxiety, neurodeg... | 01/18/2011 |
| 7863308 | Substituted thiophenes Disclosed herein are substituted pyrimidine-based endothelin modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. ... | 01/04/2011 |
| 7863276 | Salts of modulators of PPAR and methods of treating metabolic disorders Salt forms of potent modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed. ... | 01/04/2011 |
| 7855177 | Methods and kits for preventing hypoglycemia Improved methods and kits for treating the long-term complication of diabetes that reduce the risk of the patient developing hypoglycemia during C-peptide therapy. The use of such methods and kits, can also maintain good glycemic control, and avoid excessive weight ... | 12/21/2010 |
| 7834004 | Sulfonyl-substituted bicyclic compounds as modulators of PPAR Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed. ... | 11/16/2010 |
| 7825256 | Inducible nitric oxide synthase dimerization inhibitors The present invention relates to compounds and methods useful as inhibitors of nitric oxide synthase. Certain compounds of the subject invention have the following structural formula: wherein T, X, and Y are independently s... | 11/02/2010 |
| 7795216 | Methods for promoting composite tissue regeneration and uses thereof The present invention provides a use and method for GM284 to promote the regeneration of a bodily structure comprised of a composite tissue in a subject. Additionally, the present invention provides a use and method for GM284 to promote composite tissue regeneration... | 09/14/2010 |
| 7772248 | Preparation and utility of substituted imidazopyridine compounds with hypnotic effects The present disclosure is directed to modulators of GABAA receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of sleep disorders an... | 08/10/2010 |
| 7767860 | Substituted amino alcohols Disclosed herein are substituted amino alcohol anti-mycobacterial agents and/or chelation therapy agents of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. ... | 08/03/2010 |
| 7745665 | Substituted phenethylamines Disclosed herein are substituted phenethylamine alpha adrenergic receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. ... | 06/29/2010 |
| 7691904 | pH sensitive prodrugs of 2,6-diisopropylphenol The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-insoluble 2,6-diisopropylpheno... | 04/06/2010 |
| 7652060 | Small molecule rotamase enzyme inhibitors This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamas... | 01/26/2010 |
| 7638651 | Substituted cyclohexanones Disclosed herein are substituted cyclohexanone-based NMDA receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. ... | 12/29/2009 |
| 7605004 | Test strip for a lateral flow assay for a sample containing whole cells A test strip for conducting a lateral flow assay for detection of an analyte in a sample that contains cells and fluid is provided, as well as methods for making and using the test strip. This test strip is commercially usable, for example, in a diagnostic device at... | 10/20/2009 |
| 7598273 | Inhibitors of the gastric H, K-ATPase with enhanced therapeutic properties Chemical syntheses and medical uses of novel inhibitors of the gastric H+, K+-ATPase for the treatment and/or management of duodenal ulcers, heartburn, acid reflux, other conditions mediated by gastric acid secretion and/or psoriasis are descri... | 10/06/2009 |
| 7589239 | Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders The present invention is directed to novel compounds according to formula (I) wherein R1, R2, and X are as defined herein. The invention also discloses methods of preparation, pharmaceutical compositions, and methods of disease treatment utiliz... | 09/15/2009 |
| 7572816 | Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders The present invention is directed to compounds having the structure wherein R1, R2, R3, R4, R5 and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cance... | 08/11/2009 |
| 7550607 | Method of preparation of heterocyclic molecules with pharmaceutical, pharmaceutical excipient, cosmeceutical, agrochemical and industrial uses Processes for preparing racemic and optically pure 3,6-dihydro-2H-pyrans of formulae H, I, N and O are described. These compounds may be further transformed into compounds of formulae J, K, L, M, P, Q, S, T, U, V, Y and Z with potential pharmaceutical, pharmaceutica... | 06/23/2009 |
| 7531695 | Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders The present invention is directed to compounds having the structure (I) wherein R1, R2, R3, R4, R5 and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of c... | 05/12/2009 |
| 7494999 | Sulfonyl-substituted bicyclic compounds as modulators of PPAR Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed. ... | 02/24/2009 |
| 7470722 | Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease Disclosed herein are carbonyl compounds of Formula I as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central n... | 12/30/2008 |
| 7468462 | Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders The present invention is directed to novel compounds according to formulae wherein R1, R2, R3 and R4 are as defined herein. The invention also discloses methods of preparation, ph... | 12/23/2008 |
