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| Number | Title | Issue Date |
| 8153583 | Toll like receptor 3 antagonists, methods and uses Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists, and methods of making and using the foregoing are disclosed. ... | 04/10/2012 |
| 8093068 | Methods for use in human-adapting monoclonal antibodies Methods useful for human adapting non-human monoclonal antibodies are disclosed. The methods select candidate human antibody framework sequences from a human germline framework database. ... | 01/10/2012 |
| 8084232 | Polynucleotides encoding toll-like receptor 3 Isolated polynucleotides encoding Papio cynocephalus Toll-Like Receptor 3 (Baboon TLR3), polypeptides obtainable from expression of these polynucleotides, recombinant cells, and methods of use are disclosed. ... | 12/27/2011 |
| 8071103 | Pharmaceutical composition comprising a human GLP-1 mimetibody The present invention relates to at least one improved human GLP-1 mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 mimetibody or specified portion or variant, GLP-1 mimetibody or specified portion or varian... | 12/06/2011 |
| 8043616 | sRAGE mimetibody, compositions, methods and uses Mammalian sRAGE mimetibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to reduce or inhibit the binding of RAGE and its ligands and to treat RAGE-related diseases are also disclosed. ... | 10/25/2011 |
| 8017325 | Selection of high-producing cell lines The invention describes a method for screening antibody producing cell lines for selection of high expressing clones. ... | 09/13/2011 |
| 7982007 | Cynomolgus toll-like receptor 3 Isolated polynucleotides encoding Cynomolgus monkey Toll-Like Receptor 3 (cynoTLR3), polypeptides obtainable from expression of these polynucleotides, recombinant cells, methods and uses of these are disclosed. ... | 07/19/2011 |
| 7966338 | Computer-directed assembly of a polynucleotide encoding a target polypeptide The present invention outlines a novel approach to utilizing the results of genomic sequence information by computer-directed polynucleotide assembly based upon information available in databases such as the human genome database. Specifically, the present invention... | 06/21/2011 |
| 7910101 | Melanocortin receptor binding mimetibodies, compositions, methods and uses Melanocortin receptor binding mimetibody polypeptides are disclosed. Polynucleotides encoding these polypeptides, cells comprising these polynucleotides or expressing the mimetibodies, and methods of making and using the forgoing are also disclosed. ... | 03/22/2011 |
| 7888117 | Human OCT-2 variant peptide chains, nucleic acids, and methods Homo sapiens OCT-2 variant peptide chains are disclosed. Polynucleotides encoding these peptide chains, cells comprising these polynucleotides, and methods of using the forgoing are also disclosed. ... | 02/15/2011 |
| 7879978 | ST2L Isolated polynucleotides encoding Macaca fascicularis ST2L (Cyno ST2L), polypeptides obtainable from expression of these polynucleotides, recombinant cells, and methods of use are disclosed. ... | 02/01/2011 |
| 7872120 | Methods for synthesizing a collection of partially identical polynucleotides Methods for synthesizing a collection of partially identical polynucleotides are disclosed. ... | 01/18/2011 |
| 7833531 | Method for treating insulin sensitivity by long-acting GLP-1 receptor mimetibody agonists The present invention provides to at least one novel human GLP-1 receptor agonist, or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 receptor agonist, or specified portion or variant, GLP-1 receptor agonist, or specifie... | 11/16/2010 |
| 7812121 | GLP-2 mimetibodies, polypeptides, compositions, methods and uses Mammalian GLP-2 mimetibodies, polypeptides and nucleic acids are disclosed. Methods of utilizing the mimetibodies and polypeptides to treat GLP-2 related diseases are also disclosed. ... | 10/12/2010 |
| 7790871 | Anti-TNFα antibodies and methods of use Novel TNFα antibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to treat TNFα-related diseases are also disclosed. ... | 09/07/2010 |
| 7744897 | Human immunodeficiency virus gp41 mimetibody polypeptides HIV gp41 mimetibody polypeptides and encoding polynucleotides are disclosed. Methods of utilizing the polypeptides to reduce or inhibit HIV fusion with a cell membrane and entry into target cells are also disclosed. ... | 06/29/2010 |
| 7718778 | Antibody reactive with human toll like receptor 3 Toll Like Receptor 3 (TLR3) modulators, such as antibodies, polynucleotides encoding TLR3 antibodies or fragments thereof, and methods of making and using the foregoing are disclosed. ... | 05/18/2010 |
| 7666993 | Cynomolgus prostate specific antigen Isolated polynucleotides encoding Cynomolgus monkey prostate specific antigen and polypeptides obtainable from the polynucleotides and uses are disclosed. ... | 02/23/2010 |
| 7659250 | BMP-7 variant compositions, methods and uses Human Bone Morphogenic Protein 7 (hBMP-7) variant peptide chains, nucleic acids encoding these peptide chains, and methods of making and using the foregoing are disclosed. ... | 02/09/2010 |
| 7598083 | Chemically defined media compositions Chemically defined media compositions for the culture of eukaryotic cells are disclosed. The compositions are useful for eukaryotic cell culture in perfusion bioreactors and other vessels. ... | 10/06/2009 |
| 7560108 | Anti-TNFα antibodies Novel TNFα antibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to treat TNFα-related diseases are also disclosed. ... | 07/14/2009 |
| 7498150 | Materials and methods to increase peptide chain expression DNA sequences that increase peptide chain expression when operably linked to a gene encoding the peptide chain and methods of generating a peptide chain expression host cell using the foregoing are disclosed. Peptide chain expression host cells are also disclosed. | 03/03/2009 |
| 7479379 | Methods for altering protein production rates Methods for altering the cellular secretion rate of a protein, such as an antibody and the altered cells produced by the method are disclosed. The methods and altered cells are useful for producing high levels of proteins for therapeutic, diagnostic or research purp... | 01/20/2009 |
| 7342107 | Cynomolgus prostate specific antigen Isolated polynucleotides encoding Cynomolgus monkey prostate specific antigen and polypeptides obtainable from the polynucleotides and uses are disclosed. ... | 03/11/2008 |
