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| Number | Title | Issue Date |
| 8119611 | Treatment of neurodegenerative disease through intracranial delivery of SIRNA The present invention provides devices, small interfering RNA, and methods for treating a neurodegenerative disorder comprising the steps of surgically implanting a catheter so that a discharge portion of the catheter lies adjacent to a predetermined infusion site i... | 02/21/2012 |
| 8058251 | Devices, systems and methods for improving memory and/or cognitive function through brain delivery of siRNA The present invention relates to devices, systems, and methods for improving memory and/or cognitive function by brain delivery of compositions of small interfering RNA or vectors containing the DNA encoding for small interfering RNA. Such compositions can be admini... | 11/15/2011 |
| 7994149 | Method for treatment of Huntington's disease through intracranial delivery of sirna The present invention provides devices, small interfering RNAs, and methods for treating a neurodegenerative disorder comprising the steps of surgically implanting a catheter so that a discharge portion of the catheter lies adjacent to a predetermined infusion site ... | 08/09/2011 |
| 7988668 | Microsyringe for pre-packaged delivery of pharmaceuticals A microsyringe includes a body, a barrier movable within the body, and a flow regulator. The body includes a pressurizable chamber, an inlet fluidly connected to the pressurizable chamber, an outlet fluidly connected to the pressurizable chamber, and a cannula fluid... | 08/02/2011 |
| 7418292 | Device and method for attenuating an immune response Stimulation of one or more neurons of the sympathetic nervous system, including the splenic nerve, to attenuate an immune response, including an inflammatory immune response, is discussed. Devices and systems to stimulate the sympathetic nervous system to attenuate ... | 08/26/2008 |
| 7416542 | Open circuit gravity-assisted uroflowmeter An open circuit gravity-assisted uroflowmeter has a urine collector having a generally open inlet in fluid communication with a sensing passage located at a lower elevation than the inlet, the sensing passage intersecting a magnetic field and having electrodes for d... | 08/26/2008 |
| 7381180 | Implantable devices and methods for treating fecal incontinence In general, the invention is directed to treatment of fecal incontinence by the implantation of one or more bulking prostheses proximate to an anal sphincter. These bulking prostheses, which may include biocompatible hydrogel, are inserted into the tissue near the a... | 06/03/2008 |
| 7324949 | Implantable medical device management system A suite of applications is provided for the administration of implantable medical devices, particularly implantable therapeutic substance infusion devices. The applications may be accessed over a public network, such as the Internet, and may be run using middleware.... | 01/29/2008 |
| 7282050 | Ablation of exterior of stomach to treat obesity The invention provides methods and devices to treat obesity by ablating tissue from an exterior surface of a stomach of a patient. For example, the invention may involve ablation of exterior stomach tissue to alter gastric myoelectric activity or muscle function fro... | 10/16/2007 |
| 7270650 | Catheter anchor system and method A catheter system and method for intracranial infusion of therapeutic substances to a patient. An anchor formed of generally flexible, elastomeric material is used to mount the catheter to the outer surface of the skull of the patient. The anchor has a through hole ... | 09/18/2007 |
| 7252665 | Ablation of stomach lining to reduce stomach acid secretion The invention provides methods and devices to reduce stomach acid secretion in a patient with a hyper acid condition. For example, the invention may involve ablation of the stomach lining to destroy acid-producing cells. Destroying acid-producing cells may reduce th... | 08/07/2007 |
| 7238182 | Device and method for transurethral prostate treatment The invention provides a transurethral ablation device comprising a catheter sized for insertion into a urethra of a male patient. A distal end of the catheter defines a lateral cavity. A vacuum line applies vacuum pressure to the cavity to capture a portion of the ... | 07/03/2007 |
| 7214198 | Catheter system having disposable balloon A catheter system is disclosed including an elongated catheter, an elongated balloon carrier and a disposable balloon formed from an expandable and resilent biocompatible material. The balloon has a lumen disposed between a proximal end and a distal end thereof. The... | 05/08/2007 |
| 7177693 | Gastric stimulation for altered perception to treat obesity In general, an implantable medical device is disclosed for generating and applying an electric stimulation signal to a portion of a patient's gastrointestinal tract to induce symptoms of gastroparesis in the patient without substantially reducing normal stomach moti... | 02/13/2007 |
| 7153292 | Catheter for target specific drug delivery A medical catheter comprising a proximal end having an opening for fluid containing a therapeutic drug, a distal end, the distal end defining at least one opening, and a porous portion covering the opening defined by the distal end. In one embodiment, the medical ca... | 12/26/2006 |
| 7147647 | Sintered titanium tube for the management of spinal cord injury A device and method for the treatment of damaged nerves and, more particularly, a tubular membrane having a microtextured surface for the treatment of central or peripheral nerve injuries. The microtextured surface of the tubular membrane inhibits the growth of fibr... | 12/12/2006 |
| 7141016 | Systems and methods for monitoring gastrointestinal system In general, the invention is directed to systems and methods for monitoring the gastrointestinal system of a patient. In one embodiment, the invention includes techniques for monitoring the emptying of the patient's stomach. The techniques may employ glucose monitor... | 11/28/2006 |
| 7043295 | Methods and apparatus for delivering a drug influencing appetite for treatment of eating disorders Methods and systems for treating patients suffering from eating disorders, e.g. obesity, through the dispensation of a drug by an implantable infusion pump (IIP) delivering drug into the cerebral spinal fluid (CSF) at a site of the intrathecal space in amounts and a... | 05/09/2006 |
| 4866894 | Stairway construction device A bracket for use in constructing a stairway of the type having stringers and a plurality of treads and risers. The bracket includes adjacent horizontal and vertical portions attachable to tread and riser members respectively, and an upwardly angled porti... | 09/19/1989 |
| 4850738 | Roadway mat and methods for its construction A water-draining stable mat is described, made up of tires of portions of tires. The roadway mat has several layers that are borne upon and conform to a substrate of peat, dirt, sand, clay or other soil material. One layer of a roadway mat of the inventio... | 07/25/1989 |
| 4851008 | Bone implant prosthesis with substantially stress-free outer surface A bone implant prosthesis having an outer stress-free surface and a subsurface carried generally beneath and parallel to the outer surface for bearing tensile stresses. The prosthesis of the invention includes a plurality of slots undercutting the outer s... | 07/25/1989 |
| 4821866 | Conveyor for a clean room A conveyor for transporting articles to or from a clean room or from one place to another within a clean room. The conveyor has housings extending along either side of the path of conveyor travel. Extending between the housings are conveying members, usua... | 04/18/1989 |
| 4772283 | Corneal implant An implant prosthesis for replacing a full or partial thickness of a cornea. Prosthesis includes a transparent lens portion, and a carrier of preserved, denatured tissue. The lens is attached to the carrier which in turn is adapted for attachment to the e... | 09/20/1988 |
| 4729761 | Tissue-implantable, fluid-dissipating device A tissue-implantable fluid-dissipating device enabling fluid from a source to be delivered to and absorbed by tissue of the eye. In one embodiment the device includes a base plate having a radius of curvature approximately equal to that of the human eye a... | 03/08/1988 |
| 4722906 | Binding reagents and methods A method for selectively covalently linking a target moiety to a chemical moiety or carrier comprising attaching to the chemical moiety or carrier a reagent having a selector group capable of forming a specific bond with a receptor carried on the target m... | 02/02/1988 |
| 4718413 | Bone cutting guide and methods for using same Cutting guide for a bone saw used to assure accurate bone cuts in implantation of prostheses and osteotomies. A cutting guide has a main body having guide elements that include a pair of guide surfaces that engage opposite sides of a saw blade. The guide ... | 01/12/1988 |
| 4697002 | Calcitonin gene related peptide analogs with amino acid subdstituents at the penultimate position 36 New calcitonin gene related peptide analogs (CGRP) are disclosed which have biological activity of the same type as known calcitonin gene related peptides and which have an amino acid substituent at position 36 or the penultimate position instead of the n... | 09/29/1987 |
| 4687839 | Calcitonin gene related peptide analogs with C-terminal D-amino acid substituents New calcitonin gene related peptide analogs (CGRP) are disclosed which have biological activity of the same type as known calcitonin gene related peptides and which have a D-amino acid substituent in at least one of the positions 36 and 37 instead of the ... | 08/18/1987 |
| 4652627 | Calcitonin analogs with C-terminal D-amino acid substituents New calcitonin analogs are disclosed which have biological activity of the same type as known calcitonins and which have a D-amino acid substituent in at least one of the positions 31 and 32 instead of the natural L-amino acid units. The calcitonin analog... | 03/24/1987 |
| 4644054 | Calcitonin analogs with amino acid substituents at position 31 New polypeptides are disclosed which have biological activity of the same degree as known calcitonins and which have amino acid substituents in position 31 instead of the naturally occuring amino acids--Thr, Ala, Val.... | 02/17/1987 |
