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| Number | Title | Issue Date |
| 7208490 | Tricyclic tetrahydroquinoline antibacterial agents The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens ... | 04/24/2007 |
| 7202275 | Malonamic acids and derivatives thereof as thyroid receptor ligands The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias... | 04/10/2007 |
| 7199123 | Pyrazine compounds as transforming growth factor (TGF) compounds Novel pyrazine compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming gro... | 04/03/2007 |
| 7141570 | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives The present invention provides antibacterial agents having the formula I described herein. ... | 11/28/2006 |
| 7141588 | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives The present invention provides antibacterial agents having the formulae I, II, and III described herein. ... | 11/28/2006 |
| 7115632 | Sulfonyl aryl or heteroaryl hydroxamic acid compounds A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl aromatic or heteroaromatic ring hydroxamic acid ... | 10/03/2006 |
| 7108852 | Methods of treating inflammation using antibodies to M-CSF A hematopoetic factor called “colony stimulating factor” (CSF) is capable of synergizing the attracting capabilities of chemokines and of inducing the accumulation and/or activation in vitro and in vivo of key components of inflammatory responses. Various types ... | 09/19/2006 |
| 7030242 | Selective inhibition of aggrecanase in osteoarthritis treatment This invention relates to a method of treatment for osteoarthritis involving inhibitors of aggrecanase that demonstrate IC50s of less than 20 nM and demonstrate differential potency against matrix metalloproteinases (MMPs) and a disintegrin and metallopro... | 04/18/2006 |
| 6974812 | Benzamide inhibitors of the P2X7 Ereceptor The present invention provides benzamide inhibitors of the P2X7 receptor of the formula: wherein R1-R3 are as defined herein. The compounds of the invention are useful in the treatment ... | 12/13/2005 |
| 6962973 | Porcine α2δ-1 calcium channel subunit cDNA and soluble secreted α2δ-1 subunit polypeptides Soluble α2δ-1 subtype polypeptides. Methods for cloning, expression and purification of freely soluble α2δ-1 subtype polypeptides. ... | 11/08/2005 |
| 6958218 | Method for the screening of α2δ-1 subunit binding ligands A method for the screening of ligands which bind to soluble α2δ-1 subtype polypeptides. ... | 10/25/2005 |
| 6943174 | 6,5-Fused bicyclic heterocycles The present invention provides compounds of Formula (I) wherein Q1, Q2, Q3, Q4, Y1, Y2, and Z are as defined in the description, and pharmaceutically acceptable salts thereof, and C1-C... | 09/13/2005 |
| 6927219 | N-alkyl-adamantyl triazinyl benzamide derivatives The present invention relates to novel to N-alkyl adamantyl triazinyl benzylamide derivatives of formmula I: and to processs for their preparation, intermediates useful in their preparation, pharmaceutical compositions... | 08/09/2005 |
| 6906094 | 1,2,4-tribsubstituted benzenes as inhibitors of 15-lipoxygenase The present invention provides compounds of formula (I) wherein R, Z, Y, W, R5, V, and X are as defined in the description, and pharmaceutically acceptable salts thereof, which are useful for the treatment of diseases responsive to the inhibition of the e... | 06/14/2005 |
| 6900201 | N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, and G... | 05/31/2005 |
| 6890524 | Hydrolyzable delivery system using cross-linked polymeric resins as vehicles This invention provides a method of preparing a polymeric delivery system for active ingredients. The delivery system is formed either by attaching the active ingredient to a linker through a hydrolyzable covalent bond, then forming a covalent bond between the linke... | 05/10/2005 |
| 6887902 | Anti-inflammatory method using gamma-aminobutyric acid (GABA) analogs GABA analogs such as gabapentin and pregabalin are useful to prevent and treat inflammatory diseases. ... | 05/03/2005 |
| 6858739 | Indole and benzimidazole 15-lipoxygenase inhibitors This invention provides indole and benzimidazole 15-lipoxygenase (15-LO) inhibitors of the formula where one of Y1 and Y2 is CH, N, or NH, and the other is R3 includes H, halo, HN2, COOH, alkyl; R4 includes halo... | 02/22/2005 |
| 6677355 | Hydroxamic acid compounds useful as matrix metalloproteinase inhibitors Compounds of the formula; ##STR1## are useful for inhibiting matrix metalloproteinase enzymes in animals, and as such, prevent and treat diseases resulting from the breakdown of connective tissues. Also disclosed are methods for the preparation of such ... | 01/13/2004 |
