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| Number | Title | Issue Date |
| 8173382 | Assay for cardiac troponin autoantibodies The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, a... | 05/08/2012 |
| 8168165 | Alkylated interleukin-18 compositions Alkylated interleukin-18 (IL-18), compositions comprising alkylated IL-18, kits comprising such compositions, methods of alkylating IL-18, and methods of using compositions comprising alkylated IL-18. ... | 05/01/2012 |
| 8129127 | Assay for immunosuppressant drugs The invention provides immunoassays for immunosuppressant drugs, wherein the assay is carried out under high salt conditions to achieve improved sensitivity. The invention also provides kits that are useful for performing the methods of the invention. ... | 03/06/2012 |
| 8022188 | Immunosuppressant binding antibodies and methods of obtaining and using same The present invention relates among other things to antibodies that immunospecifically bind to at least one agent of interest (e.g., an immunosuppressive agent), methods for producing such antibodies, and immunoassays that employ said antibodies. Additionally, the p... | 09/20/2011 |
| 8013112 | Compositions comprising human brain natriuretic peptide (BNP) fragments The present invention relates among other things to a composition comprising at least two (2) human BNP fragments, wherein each of the human BNP fragments of the composition are cross-linked to at least one of the other human BNP fragments of the composition. ... | 09/06/2011 |
| 7993851 | Lysis reagent for use with capture-in-solution immunoassay The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent inc... | 08/09/2011 |
| 7939069 | Human BNP immunospecific antibodies The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain ... | 05/10/2011 |
| 7923210 | Methods to measure immunosuppressive tacrolimus, sirolimus, and cyclosporin a complexes in a blood sample The present invention provides methods, diagnostic assays, and diagnostic kits based on said methods, to determine levels of immunosuppressive complexes containing immunosuppressive drugs tacrolimus, sirolimus and cyclosporine A separately and in combination, formed... | 04/12/2011 |
| 7914999 | Non-denaturing lysis reagent The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent inc... | 03/29/2011 |
| 7906293 | Acridinium phenyl esters useful in the analysis of biological The present invention relates to methods and kits for detecting an analyte in a test sample using acridinium-9-carboxylate aryl esters. ... | 03/15/2011 |
| 7897332 | Methods for the detection of HIV-1 or -2 antigens employing monoclonal antibodies that recognize a shared HIV-1/-2 epitope in the capsid p24/p26 proteins The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared... | 03/01/2011 |
| 7883855 | Immunosuppressant drug extraction reagent for immunoassays An improved extractive reagent composition and method for extracting an immunosuppressant drug, such as sirolimus, tacrolimus or cyclosporine, from blood samples while yielding a test sample extract that has low vapor pressure and is compatible with immunoassay comp... | 02/08/2011 |
| 7883845 | Antigen constructs useful in the detection and differentiation of antibodies to HIV Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constr... | 02/08/2011 |
| 7858752 | Recombinant antibodies against hepatitis C virus and methods of obtaining and using same Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diag... | 12/28/2010 |
| 7811749 | Measuring free choline to determine suitability of erythrocytes for transfusion A method of assessing whether or not erythrocytes are suitable for transfusion into a recipient comprising (i) assaying a sample of erythrocytes for free choline, and (ii) comparing the level of free choline in the sample with the level of free choline deemed suitab... | 10/12/2010 |
| 7776605 | Assay for cardiac troponin autoantibodies The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, a... | 08/17/2010 |
| 7749717 | Methods for the detection and diagnosis of infection The present invention relates to the diagnosis of Trypanosoma cruzi infection. ... | 07/06/2010 |
| 7731965 | Human ring specific BNP antibodies The present invention relates to antibodies that specifically bind to human BNP and immunoassays using said antibodies in the quantification of human BNP or a fragment of human BNP in a test sample. ... | 06/08/2010 |
| 7718380 | Method of tacrolimus extraction and quantification using aqueous detergents The present invention relates to a method of extracting tacrolimus in a test blood sample to use in a tacrolimus quantification assay. The method of the present invention extracts tacrolimus in non-precipitating, non-denaturing aqueous environment, avoiding cumberso... | 05/18/2010 |
| 7674623 | Method of stabilizing human natriuretic peptides The present invention relates to methods for making stable test samples that can be used in ligand-binding assays for measuring natriuretic peptides. ... | 03/09/2010 |
| 7615614 | Antigen constructs useful in the detection and differentiation of antibodies to HIV Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constr... | 11/10/2009 |
| 7615613 | Antigen constructs useful in the detection and differentiation of antibodies to HIV Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constr... | 11/10/2009 |
| 7592186 | Methods to measure immunosuppressive tacrolimus, sirolimus, and cyclosporin A complexes in a blood sample The present invention provides methods, diagnostic assays, and diagnostic kits based on said methods, to determine levels of immunosuppressive complexes containing immunosuppressive drugs tacrolimus, sirolimus and cyclosporine A separately and in combination, formed... | 09/22/2009 |
| 7575875 | Method of tacrolimus extraction and quantification using aqueous detergents The present invention relates to a method of extracting tacrolimus in a test blood sample to use in a tacrolimus quantification assay. The method of the present invention extracts tacrolimus in non-precipitating, non-denaturing aqueous environment, avoiding cumberso... | 08/18/2009 |
| 7531642 | Monoclonal antibodies that recognize a shared epitope between the human immunodeficiency virus type 1 (HIV-1) capsid (CA/p24) and the human immunodeficiency virus type 2 (HIV-2) capsid (CA/p26). The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared... | 05/12/2009 |
| 7531641 | Monoclonal antibodies that recognize a shared epitope between the human immunodeficiency virus type 1 (HIV-1) capsid (CA/p24) and the human immunodeficiency virus type 2 (HIV-2) capsid (CA/p26) The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared... | 05/12/2009 |
| 7531640 | Monoclonal antibodies that recognize a shared epitope between the human immunodeficiency virus type 1 (HIV-1) capsid (CA/p24) and the human immunodeficiency virus type 2 (HIV-2) capsid (CA/p26) The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared... | 05/12/2009 |
| 7531639 | Monoclonal antibodies that recognize a shared epitope between the human immunodeficiency virus type 1 (HIV-1) capsid (CA/p24) and the human immunodeficiency virus type 2 (HIV-2) capsid (CA/p26) The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared... | 05/12/2009 |
| 7531638 | Monoclonal antibodies that recognize a shared epitope between the human immunodeficiency virus type 1 (HIV-1) capsid (CA/p24) and the human immunodeficiency virus type 2 (HIV-2) capsid (CA/p26) The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared... | 05/12/2009 |
| 7528238 | Monoclonal antibodies that recognize a shared epitope between the human immunodeficiency virus type 1 (HIV-1) capsid (CA/p24) and the human immunodeficiency virus type 2 (HIV-2) capsid (CA/p26) The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared... | 05/05/2009 |
| 7445933 | Stable calibrators or controls for measuring human natriuretic peptides The present invention relates to a stable liquid calibrator or control for use in ligand-binding assays wherein the calibrator or control comprises at least one human synthetic natriuretic peptide and has a pH of from about 4.0 to about 6.5 and remains... | 11/04/2008 |
| 7432046 | Methods for the determination of antibody IgG avidity The present invention relates to methods of determining anti-infectious agent IgG avidity, for example, human anti-cytomegalovirus and human anti-toxoplasma IgG avidity, using a competitive assay format. ... | 10/07/2008 |
| 7393933 | Hepatitis B monoclonal antibodies A monoclonal antibody that is capable of binding specifically to wild type HBsAg and to at least two mutant forms of HBsAg may be used in an improved immunoassay for the detection of both escape mutants and wild type HBsAg and may be used for passive immunisation ag... | 07/01/2008 |
| 7291501 | Stable compositions for measuring human natriuretic peptides The present invention relates to methods for making stable compositions, such as, but not limited to, test samples, that can be used in ligand-binding assays. ... | 11/06/2007 |
